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Biomedical subjects

B G Clark

Publications and source records attributed to B G Clark.

32 records · Page 2Linked to original sources

A halo-ring technique for fractionated stereotactic radiotherapy.

Stereotactic radiosurgery has become established as an effective treatment modality for certain non-malignant brain diseases such as arteriovenous malformations. This paper describes an extension of our linear accelerator-based radiosurgical technique to fractionated treatment of intracranial disease. The fractionated stereotactic radiotherapy technique expands the use of the modality by sparing normal cells within the treatment volume thus improving the therapeutic ratio. The first treatment is given using a stereotactic frame both for target localization and patient immobilization. The frame is then removed and subsequent treatments use a standard neurosurgical halo-ring for patient immobilization. The halo-ring is left in place on the skull for the duration of the course of treatment. Thus the physical requirements for fractionation pertain firstly to the patient immobilization and target localization using the halo-ring and secondly to the stringent quality assurance procedures required to maintain spatial accuracy under these new conditions. We describe a sensitive and effective technique for checking the rotational beam parameters and collimator alignment which we use immediately prior to treatment to ensure adequate accuracy of dose delivery to the target volume.

Equipment Design↗

Standard compensators for ENT therapy fields.

Radiotherapy of the ENT region is frequently applied through two parallel-opposed, lateral fields covering a volume from the maxillary sinus to the base of the neck, with the isocentre close to the angle of the mandible. The large variation in separation throughout this volume, in both the transverse and the coronal planes, leads to field inhomogeneities which are often resolved by the use of custom designed, two-dimensional compensators. This paper presents an alternative method of compensation using a set of one-dimensional, standard compensators applied in the coronal plane which, in conjunction with a wedge in the transverse plane, yields a uniform distribution throughout the treatment volume for the majority of patient configurations. The advantages of this technique are the immediate availability of a computerised treatment plan incorporating the compensator, an increase in the dose homogeneity obtainable over that without compensation and the elimination of any delay which may be incurred by the design and fabrication of custom made compensators.

Head and Neck Neoplasms↗

Bromperidol. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in psychoses.

Bromperidol is a close structural analogue of haloperidol. Both agents possess similar pharmacodynamic properties which are consistent with central antidopaminergic activity. The available clinical data from non-comparative and comparative trials have shown that bromperidol possesses antipsychotic activity. Its overall efficacy was slightly greater than chlorpromazine and perphenazine, and similar to or slightly better than haloperidol in a small number of comparative studies. Bromperidol frequently displayed a faster onset of action than these comparative agents and there have been reports of bromperidol causing an activating effect. However, extrapyramidal side effects occurred with similar frequency and severity after bromperidol compared with the 3 reference drugs. Data from additional controlled clinical trials are required to confirm the comparative antipsychotic efficacy of bromperidol and to assess whether it possesses any advantages in certain sub-types of schizophrenia.

Clinical Trials as Topic↗

Loprazolam. A preliminary review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy in insomnia.

Loprazolam is a 1,4-benzodiazepine with hypnotic properties, advocated for use in acute or chronic insomnia. As loprazolam has a half-life of 7 to 8 hours in healthy adults it may have advantages over longer-acting hypnotics, particularly when residual sedative effects on the day after ingestion are undesirable, although at doses greater than 1 mg residual sedation may occur. In addition, it may reduce daytime anxiety, following a hypnotic dose the night before, more effectively than the short-acting drug, triazolam. In short term comparative studies loprazolam was clearly superior to placebo, and was at least as effective as triazolam, flurazepam, nitrazepam, flunitrazepam or temazepam in hastening sleep onset, reducing nocturnal awakenings and increasing total sleep duration and quality. In the small number of patients with chronic insomnia who have received extended treatment with loprazolam, no evidence of tolerance has occurred, although rebound insomnia was evident 3 days after drug withdrawal in several studies. Thus, with its 'intermediate' elimination half-life, loprazolam would appear to have some potential advantages over both long- and short-acting hypnotics in selected patients, although further studies are needed to fully elucidate its place in therapy.

Anti-Anxiety Agents↗

Inservice teaching and adverse drug reactions in a nursing home.

A prospective study was carried out in two skilled nursing facilities (SNFs) to determine: the feasibility of identifying potential adverse drug reactions (ADRs) by monitoring drug order changes; the ADR rate in the elderly in SNFs; the ease of using an algorithm to assess the probability that an adverse event is drug-related; and whether a one-hour inservice lecture could alter the number of drug order changes or the number of ADRs detected. Over three months, 27 of 248 order changes (10.8 percent) were identified as possible ADRs. Fifteen of 248 (six percent) of the orders were probable or definite ADRs. The ADR rates were 9.5 percent and 14.8 percent, for the study and control SNFs, respectively (p greater than 0.05). This method of detecting ADRs depends on recognition of a clinically observable adverse event by the nurse, nurse practitioner, or physician. Therefore, the hypothesis that an inservice lecture on ADRs could increase the recognition of ADRs was tested. More drug order changes were initiated in the control facility that retained a full-time nurse practitioner, but no change in the number of drug order changes or ADR rates was seen after the inservice lecture in the study facility. This method is the first to identify, prospectively, clinically manifest ADRs and to test a method to influence their rate in nursing home elderly.

Aged↗

Adverse drug reactions in the elderly: case studies.

ADRs in the elderly may present in an atypical manner. Atypical reactions are uncommon and usually cannot be anticipated from the chemical or pharmacologic properties of the drug. In many cases, you may find a careful and thorough drug history and knowledge of drug-related reactions more helpful than an array of laboratory data.

Acetazolamide↗

Female preponderance in diuretic-associated hypokalemia: a retrospective study in seven long-term care facilities.

A retrospective review of the medical records of 161 geriatric nursing-home patients receiving diuretics alone or in combination with potassium supplements or potassium sparing-diuretics revealed a 13.7 per cent overall prevalence of hypokalemia. The prevalence of hypokalemia in patients receiving diuretics alone, diuretics with potassium supplements, and potassium-sparing diuretics with kaliuretic diuretics were similar. However, there was a significantly higher prevalence of hypokalemia in women (16.4 per cent) compared with men (3.0 per cent), P less than 0.05. In patients taking non-chloride salts of potassium, there was a significantly higher prevalence of hypokalemia than in those taking the chloride salt (3.6 per cent vs. 8 per cent, P less than 0.025). Seven per cent of patients taking diuretics with potassium supplements and 11.5 per cent of patients taking potassium-sparing diuretics had hyperkalemia. Thus, although many elderly women taking diuretics may have hypokalemia routine potassium supplementation for all non-digitalized geriatric patients receiving diuretics does not seem to be indicated.

Aged↗

Propranolol-induced dyspnea in a nonasthmatic male.

The authors report the onset of wheezing and dyspnea in a 32-year-old, nonasthmatic male who was receiving propranolol for chronic migraine headaches of 20 years' duration. The symptoms first appeared during the "cold season"; the diagnosis was bronchitis. After three months without propranolol, the patient, prompted by continuing migraine headaches, again took the drug (40 mg bid). Within 48 hours he complained of rhinitis that rapidly progressed to wheezing, resembling bronchitis. Other reports in the literature are discussed.

Adult↗

Effect of comprehensive pharmaceutical services on drug use in long-term care facilities.

The effect of comprehensive pharmaceutical services on drug consumption and cost in long-term care facilities was studied over an eight-year period. Medication administration records for 1970-1977 were obtained for all patients in three long-term care facilities served by a centralized pharmaceutical service. Services included unit dose drug delivery, drug use and chart review, and medical staff consultation. Data from a 10% sample of 4,004 patient records were analyzed. A significant (p less than 0.05) decline in the number of prescription drugs (42.8%) and the number of prescription doses (34.6%) consumed occurred over the eight-year period. The number of nonprescription drugs decreased significantly by 34.4%, but consumption of nonprescription drug doses was not changed significantly. When adjusted for inflation, the average monthly medication bill per patient decreased 28.9%, with the average for Medicaid patients being significantly (p less than 0.001) greater than that for private-pay patients. No significant changes occurred in the therapeutic categories of drug use. Centralized pharmaceutical services, pharmacist consultation and drug use review significantly reduced drug use and medication costs in the facilities studied.

Aged↗