Biomedical subjects

B Friend

Publications and source records attributed to B Friend.

At least 37 records · Page 2Linked to original sources

PubMed1995

Management consultancy. Outside in.

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Consultants↗

PubMed1976

Metabolic responses of rats to chronic theophylline ingestion.

Studies of the metabolic responses of rats to 0.2% dietary theophylline were conducted. Young male rats were fed theophylline-containing diets or control diets for 8 wk and killed after 22 hr without food. Levels of serum lipids, glucose, and ketones were determined as were hepatic glycogen, lipid, calcium, magnesium, and zinc levels. Epididymal fat pad lipid content, as well as kidney cation levels and hepatic mitochondrial respiration, was also determined. Chronic theophylline feeding lowered blood glucose levels, serum triglyceride levels, hepatic lipid and calcium levels, and the state III respiration with succinate as the substrate. Kidney calcium and magnesium levels were elevated in theophylline-fed rats as were the serum cholesterol levels. The relationship of these metabolic responses to theophylline feeding is discussed as a function of the theophylline effect on tissue cation levels.

Adipose Tissue↗

PubMed1975

The effects of a polychlorinated biphenyl mixture (Aroclor 1254) on liver gluconeogenic enzymes of normal and alloxan-diabetic rats.

Normal and alloxan-diabetic rats were fed ground Purina Laboratory Chow with or without 500 ppm of Aroclor 1254 (AR) ad lib for 2 weeks. In both normal and diabetic rats, AR administration decreased food consumption, weight gain and blood glucose concentration, and increased liver weight, liver:body weight ratio, total liver lipid, liver protein and malic enzyme (ME) activity. In the normal rat, AR increased the concentrations of acetoacetate and beta-hydroxybutyrate in blood, but in the diabetic rat the concentrations were markedly reduced. AR administration decreased the activity of phosphoenolpyruvate carboxykinase (PEPck) in normal liver and the activities of pyruvate carboxylase (PC), PEPck and glucose-6-phosphatase (G6Pase) in diabetic liver.

Acetoacetates↗

PubMed1974