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Biomedical subjects

B Friedrich

Publications and source records attributed to B Friedrich.

179 records · Page 10Linked to original sources
PubMedDate not supplied

[Polio-like myelitis due to Coxsackie-Virus B 3: Course under treatment with pleconaril].

Enteroviruses are common with infections of the CNS, such as encephalitis and myelitis, but they may cause various diseases in different organ systems, particulary with fatal outcome. Pleconaril is a new orally acting antiviral drug with broad anti-picornavirus activity, which provides to treat rhinoviral and enteroviral infections. To explain the importance for clinical use, we report a case of severe enteroviral infections of the CNS, treated by Pleconaril. A 14 year old girl presented with a severe polio- like myelitis including flaccid paraparesis and urinary incontinence due to Coxsackievirus-infection. Because of prolonged course and virus persistence we treated with Pleconaril, after treatment a remarkable improvement could be noticed, continency and the ability to walk without aid were regained within a few weeks. With the development of new antiviral substances we are now given more opportunities to treat infectious conditions of the central nervous system. We suggest to include enteroviruses in diagnostic procedures since there is an effective treatment with the new drug Pleconaril available.

Adolescent↗
PubMedDate not supplied

Uncoupling of c-myc mRNA expression from G1 events in human T lymphocytes.

Normal human T-cells were grown in interleukin 2 (IL-2) until they became quiescent. Treatment with the phorbol-ester Phorbol-12, 13-dibutyrate (PBt2) made the cells competent to respond to IL-2 by expression of high affinity IL-2 receptors. These cells could be considered as G1 cells as they also displayed increased uridine incorporation, but they did not proceed into the S phase. c-myc mRNA expression was induced both by the phorbol ester and by IL-2, provided that receptors were present. A pulse with PBt2 increased c-myc mRNA transiently, while responsiveness to IL-2 and IL-2 receptors was maintained long after c-myc expression had subsided. IL-2 induced and maintained c-myc mRNA levels for more than 10h. Thus c-myc mRNA was expressed both when the cells were made competent to respond to the growth factor and when the cells progressed towards and through the S phase. In T lymphocytes c-myc mRNA expression was thus regulated in a complex way and was not necessary for maintaining G1 functions.

Gene Expression Regulation↗