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Biomedical subjects

B Freitag

Publications and source records attributed to B Freitag.

25 records · Page 2Linked to original sources
PubMed1985

Unresponsiveness to experimental allergic encephalomyelitis in Lewis rats pretreated with complete Freund's adjuvant.

A single injection of complete Freund's adjuvant blended with aluminum hydroxide gel (ALU-CFA) was successfully used to prevent clinical as well as histologic experimental allergic encephalomyelitis (EAE) in Lewis rats for more than 330 days. Adjuvant preparations with Mycobacterium tuberculosis were more potent than those with Mycobacterium butyricum. Neither the removal of the ALU-CFA inoculum nor a splenectomy 1 month after immunization arrested the adjuvant induced unresponsiveness. However cyclophosphamide restored responsiveness in more than half of the treated animals when applied 2 days before the encephalitogenic challenge at a dose of 20 mg/kg. Passive EAE was not prevented by the ALU-CFA pretreatment. The disease was induced by the transfer of 4 X 10(6) T lymphocytes of a cell line reactive against myelin basic protein. This indicates that the adjuvant prevents EAE at the inductive rather than at the effector phase of the autoimmune response.

Age Factors↗
PubMed1980

[Pharmaco-angiography of liver tumours (author's transl)].

In 36 patients with clinical suspicion of liver tumours, pharmaco-angiography using adrenalin was added to the usual liver arteriography. In 31 of these patients rumour involvement of the liver was confirmed by surgery, laparoscopy or autopsy. In four out of ten patients with benign liver tumours, pharmaco-angiography lead to improved demonstration and therefore classification of the tumour. Four out of seven malignant primary tumours. Four out of seven malignant primary tumours of the liver were also better demonstrated by pharmaco-angiography. Amongst 14 patients with liver metastases, an improvement in the angiographic demonstration by pharmaco-angiography was achieved in nine. This was particularly the case in tumours showing tumour vessels. Neither benign nor malignant tumours showed constriction of their vessels as a result of pharmaco-angiography and this is therefore not able to differentiate between these. It was also found that tumours showing the the same histology could behave differently during pharmaco-angiography.

Adenoma↗