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Biomedical subjects

B Fredricsson

Publications and source records attributed to B Fredricsson.

At least 55 records · Page 3Linked to original sources
PubMed1983

Influence of metronidazole treatment on the vaginal microbiological flora.

In order to study the effects of metronidazole on the microbiology of the vagina in general and on Gardnerella vaginalis infection in particular, quantitative aerobic and anaerobic bacterial cultures were performed before and 4 weeks after initiation of metronidazole treatment, 400 mg three times daily for five days. Bacteriological results were compared with microscopic findings and with the results of "amine testing" with potassium hydroxide and with other clinical variables. We found a reasonably good correlation between the finding of clue cells, positive amine test and symptomatic Gardnerella infection. Treatment with metronidazole resulted in most cases in recolonization with lactobacilli and disappearance of clinical symptoms and findings, including clue cells, although G. vaginalis could still be detected.

Adult↗
PubMed1982

Testosterone concentration within the tunica vaginalis of boys and adult men.

The testosterone level in fluid contained in the tunica vaginalis has been determined in 25 adult men referred for infertility and in 20 boys aged 0-10.5 years operated on for hydrocele. The median concentrations of testosterone were found to be 392 nmole/1 (range 78-957) and 1.1 nmole/1 (range 0.16-182), respectively. The median value for adult men was 20 times the concentration of testosterone found in the peripheral blood of that group while the median value for the boys was 4 times that found in their peripheral blood. It is concluded, firstly, that the high level of testosterone in the peritesticular space of adult men strongly indicates that diffusion of testosterone through the testicular capsule does take place. Secondly, testosterone levels in fluid from the peritesticular space which significantly exceeds those in peripheral blood in prepubertal boys furnishes evidence of testicular secretion of testosterone in that age group. Consequently, the peritesticular tissues such as the epididymis, gubernaculum and scrotum are exposed to quantities of testosterone far exceeding those brought by the general circulation.

Adult↗
PubMed1981

Effects of prolactin and bromocriptine on the luteal phase in infertile women.

Infertile women with regular periods but with shortened luteal phases were found to have higher mean levels of serum prolactin and lower serum progesterone levels in the midluteal phase than women with apparently normal ovarian function (P less than 0.001). Serum estrogens and gonadotropins did not differ from the reference group but the ratio FSH/LH was reduced in the midluteal phase (P less than 0.05). LHRH-loading test in the midfollicular phase also resulted in a lower ratio of FSH/LH (P less than 0.05). Thirty-six infertile women with short luteal phases were treated with bromocriptine in a double-blind fashion. The drug moderately reduced the length of the cycle (P less than 0.01). The hyperthermia of the luteal phase was measured planimetrically. Both the total area and the area per day of the luteal phase were significantly increased during the cycles of active treatment (P less than 0.02 and 0.05, respectively). Prolactin was depressed by the drug. After cessation of therapy a very significant rebound elevation of prolactin for at least 2 wk was noted. Bromocriptine therapy further reduced FSH levels at midcycle. Estrogens were elevated during the midluteal phase whereas progesterone was not affected by the treatment. Seven conceptions occurred during the study, six of which during placebo treatment. The conception cycles were characterized by significantly higher levels of progesterone and estrogens during the luteal phase as opposed to the infertile cycles. Four of the pregnancies terminated in spontaneous abortion. The endocrine data of these conception cycles did not differ from those of the successful ones.

Adult↗
PubMed1980

Effect of clomiphene citrate on testicular steroid metabolism in man.

Administration of clomiphene citrate to males with normal peripheral testosterone levels increased the serum levels of FSH, LH, testosterone and low polar oestrogens and also the urinary excretion of LH, low polar oestrogens, dehydroepiandrosterone, androsterone and aetiocholanolone. No significant change was noted for the urinary excretion of 17-oxogenic steroids. Addition of clomiphene citrate (10(-4) to 2 X 10(-3) M) to incubations of [7-3H, 21-14C] progesterone with human testicular biopsy specimens in vitro caused a slight inhibition in the formation of 17 alpha-hydroxyprogesterone and a slightly increased formation of 20 alpha-hydroxy-4-pregnen-3-one but no measurable changes in the C19 steroid formation. The results support the hypothesis that there is selective action of clomiphene citrate upon the adrenal C19 steroid biosynthesis in the human male, combined with an indirect effect upon the testes via the hypothalamic-pituitary system. A direct effect on the gonadal steroidogenesis can, however, not be ruled out.

Adult↗
PubMed1979

Morphologic evaluation of spermatozoa in different laboratories.

The principles of morphologic evaluation of human spermatozoa may vary from time to time and between different laboratories. These principles are reflected in the mean and standard deviation of the results obtained from analysis of samples delivered by all new patients. These figures and distribution diagrams based on the same data were collected from eight different scandinavian fertility laboratories. It is suggested that such data should be used to define the investigational profile of the laboratory in question and to check that inadvertent changes in the principles of evaluation do not develop. The data may also be used to calculate correction factors in order to facilitate the comparison of results when the patient has delivered samples to more than one laboratory.

Clinical Laboratory Techniques↗
PubMed1978

Short-term variations in urinary estriol and renal function. Possible effects of extraneous conditions.

Variation in urinary excretion of estriol was found to be related to physical activity and climate conditions. Estriol content of sweat was studied but was found not to be of an order to explain the variation observed. Estriol clearance rate was significantly reduced even by moderate physical activity. Creatinine clearance was not affected to the same extent. Different explanations to the findings are discussed. The need for strictly standardized conditions during urine sampling for estriol assays in risk pregnancies is stressed.

Activity Cycles↗
PubMed1977

On the morphology of live spermatozoa of human semen.

Live and dead spermatozoa of human semen were distinguished and evaluated separately with respect to their morphology after supravital staining with buffered eosin. This evaluation was shown to be almost as reliable as that of the commonly stained smear. Different samples from the same individual were found to be similar with respect to both the total population and the live population. Different types of abnormalities were not equally common in the live and dead populations. Tapered heads were more common in the live population and abnormal midpieces more common in the dead, whereas abnormal tails and cytoplasmic droplets occurred with the same frequency in both populations. However, neither the frequency of all spermatozoal abnormalities nor that of abnormal heads or midpieces studied separately showed strong correlations in the two populations, in contrast to the frequencies of tapered heads, cytoplasmic droplets, and abnormal tails. No constant relationship was found between the live population and the entire sperm population with respect to numerical differences or quotients between the figures for abnormal cell frequency.Therefore, study of the morphology of the live sperm population gives supplementary information about the qualities of semen not attained by previous methods of study.

Cell Count↗
PubMed1977

Morphology of postcoital spermatozoa in the cervical secretion and its clinical significance.

Morphologic analysis of spermatozoa recovered 10 hours postcoitally from the human female genital tract and its correlation to the clinical situation have shown that (1) spermatozoa in the vagina are equivalent to those in the semen sample; (2) spermatozoa within the cervical secretion exhibit significantly better morphology than do those of the semen sample, indicating the presence of a barrier against abnormal spermatozoa at the level of the external os; (3) this barrier is significantly more effective in cases where conceptions later occur than in cases of persistent, unexplained infertility; and (4) the barrier is particularly active against spermatozoa with abnormal heads.

Adult↗
PubMed1977

Is there a changing epidemiology of premalignant lesions of the cervix? Results of cytologic screening of pregnant women.

The selection of women approached for cytologic screening is based on previous studies on age distribution and prevalence and consequent considerations on the risk of developing invasive carcinoma. In order to check if this is appropriate the results of the screening of pregnant women being selected irrespective of their age has been studied for two periods, 1961-64 and 1972. The frequency of lesions was remarkably high among the teenagers of both periods. A significant increase in the incidence of lesions was noted for the period 1972. This increase is most evident in the ages 21 to 30. A shift to more severe lesions was found among the teenagers and in the groups between 31 and 40. In conclusion more effort should be made with respect to cytologic screening of young women, particularly when pregnant. The increased frequency of cytologic atypias among women between 21 and 30 should focus the attention to the possibility that the epidemiology or premalignant lesions of the uterine cervix is changing.

Adolescent↗