Biomedical subjects
B Francis
Publications and source records attributed to B Francis.
Use of 3-quinuclidinyl 4-iodobenzilate as a receptor binding radiotracer.
3-Quinuclidinyl 4-iodobenzilate was shown to bind to the muscarinic acetylcholine receptor (mAChR) by testing the saturability and the stereoselectivity in the corpus striatum, cerebellum, and the heart. But the ratio of radioactivity in tissues containing different concentrations of mAChR was less than the ratio of mAChR concentrations determined by in vitro saturation assay. As a result, the sensitivity to change in receptor concentration by external imaging will be reduced for this receptor binding radiotracer.
[77Br]-17-alpha-Bromoethynylestradiol: in vivo and in vitro characterization of an estrogen receptor radiotracer.
Explore the source record for details and available documents.
The use of tritium labeled compounds to develop gamma-emitting receptor-binding radiotracers.
In an effort to evaluate receptor binding drugs for their potential as gamma labeled radiopharmaceuticals suitable for clinical heart scanning, in vivo data were compared with the results obtained from a theoretical model. The distribution of selected tritium-labeled, receptor-binding radiotracers was studied in animals to determine if the heart to blood ratios agree with those obtained using a theoretical model of receptor binding. In general, the in vivo studies agree with the theoretical model when the concentration of the radiotracer in the heart is due to specific receptor binding. The use of the theoretical model for a first approximation followed by in vivo biodistribution studies is an efficient strategy to select those few from among the large number of receptor binding compounds that will ultimately yield an efficacious radiopharmaceutical to study receptor changes in the intact human heart.
Career choices. LPN viewpoint.
Explore the source record for details and available documents.
Personalized care in the I.C.U.
Explore the source record for details and available documents.
Flexibility in nursing careers.
Explore the source record for details and available documents.
LPN viewpoint: should you climb the ladder?
Explore the source record for details and available documents.
LPN viewpoint: should you climb the ladder?
Explore the source record for details and available documents.
One reaction to guilt: denial.
Explore the source record for details and available documents.
Acute calcific quadriceps tendinitis.
Acute calcific quadriceps tendinitis can be the cause of acute periarthritis of the knee. Physical examination can detect cellulitis and a tender tendon sheath. Lateral roentgenograms of soft tissues show thickening of the tendon and sometimes small flecks of amorphous calcification within the body of the tendon near the attachment. Although hyperostosis of the patella near the tendon attachment is often present, it is well defined ossification and not associated with the acute symptoms. The amorphous calcium deposits quickly disappear during the acute tendinitis and are not detected on follow-up radiologic examination.