Biomedical subjects
B Fox
Publications and source records attributed to B Fox.
Liquid paraffin pneumonia--with chemical analysis and electronmicroscopy.
Liquid paraffin pneumonia was diagnosed after open lung biopsy in a woman age 73 with a hiatus hernia and rheumatoid arthritis who had been taking liquid paraffin nightly for fifty two years. Histological examination showed a lipid type pneumonia with involvement of alveoli, interstitial tissues and brochioles. Chemical analysis of the lung showed total lipids of 17.7% (w/w), 86% was liquid paraffin which was positively identified by infrared spectroscopy. Transmission electronmicroscopy showed macrophages in the alveoli filled by phagosomes. The alveoli were mainly lined by alveolar type II cells. Scanning electronmicroscopy showed alveoli filled by a mass of vacuoled material.
Increased incidence of abnormal nasal cilia in patients with retinitis pigmentosa.
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An indirect technique for establishing preferences for categories of reinforcement for severely and profoundly retarded individuals.
The development of a reinforcement survey hierarchy is described for programming severely and profundly retarded individuals. The survey identifies reinforcement preferences of severely and profoundly retarded individuals by means of an indirect categorical technique. The categorical technique views reinforcement as being educationally, environmentally, and developmentally characteristic of severely and profoundly retarded individuals. The survey is a preliminary step to more direct approaches to reinforcement, such as sampling or use of multiple reinforcements. Field data are discussed.
Modification of donor pretreatment prolongs canine renal allograft survival.
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Development of dental health education. The contribution of the Dental Board.
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Peptide inhibitors of converting enzyme.
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Effect of lysolecithin on gastric mucosal structure and potential difference.
The effect of lysolecithin (100 mg%) on the guinea-pig gastric mucosa was studied by instilling a solution for 30 minutes, preceded and followed by 100 MN HCl into 10 total gastric pouches. Ten control animals had HCl throughout. Lysolecithin produced a significant change in transmucosal potential difference, macroscopic erosions, and mucosal damage on histology and electron scanning microscopy. None of these changes was seen in the control animals. This is further evidence that the reflux of lysolecithin from the duodenum is an important factor in causing active gastritis and gastric erosions.
Primary mediastinal trophoblastic teratomas.
Three cases of primary mediastinal trophoblastic teratoma are described. One patient died from respiratory failure during the initial chemotherapy, Another patient with advanced disease is now apparently free from disease after multiple-drug chemotherapy. The third patient is alive and well four years after a combination of surgery, radiotherapy, and multiple-drug chemotherapy. In the diagnosis and assessment of response to treatment in these tumours emphasis is placed on the measurement of the tumour cell markers, chorionic gonadotrophin and alpha-fetoprotein, by radioimmunoassay. The efficacy of multiple-drug regimens is discussed together with a review of the literature.
Adrenal haemorrhage, apoplexy, and infarction.
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Venous infarction of the adrenal glands.
An investigation of 78 cases of adrenal haemorrhage and necrosis disclosed that 32 were examples of adrenal venous infarction. In all these cases there was thrombosis of the main adrenal vein and in most there was also thrombosis of the capsular veins, a finding which has not been well established. In a number of cases with venous infarction there was clinical and pathological evidence that disseminated intravascular coagulation (DIC) had occurred, but it appears that it was not the direct cause of venous thrombosis. The majority of cases of venous infarction occur in patients with severe infection, frequently of the respiratory tract. Venous infarction was found in five cases with hypothermia an association which had rarely been described, and in three of these there was evidence of DIC. This is apparently the first occasion on which DIC has been demonstrated in cases of hypothermia in man. The cause of venous thrombosis in the adrenal glands is obscure in most cases of venous infarction, although in three it was due to involvement by metastatic carcinoma. It is suggested that the factors responsible for the initiation of thrombosis in the adrenal veins are catecholamines, thrombin, fibrin and endotoxin. Localisation of the thrombi to the adrenal vein is due to the unique anatomical structure of the vein which, under certain circumstances, results in the local stasis of blood.
Is intestinal metaplasia of the gastric mucosa a pre-malignant lesion?
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