Search PubMed⌕ Search

Biomedical subjects

B Fischer Hansen

Publications and source records attributed to B Fischer Hansen.

27 records · Page 2Linked to original sources
PubMed1997

Pattern of malformations in the axial skeleton in human trisomy 13 fetuses.

The purpose of this study was to analyse the development of the axial skeleton in human trisomy 13 fetuses and to define which fields in the axial skeleton are affected in this condition. We investigated nine human fetuses with trisomy 13 and gestational ages of 14-19 weeks. Whole body radiographs and radiographs of midsagittal tissue blocks of the cranial base and the spine were studied. In the youngest fetus, 14 w GA, no malformations were observed. In eight fetuses, 17-19 weeks GA, malformations occurred in the lumbosacral spine. In four fetuses additional malformations were observed in the thoracic spine. The study showed that there was a correspondence between the extent of malformation in the lumbosacral spine and the thoracic spine. When mild malformation occurred in the lumbosacral region, no malformation was observed in the thoracic region, whereas malformation was observed in the thoracic region when there was extensive malformation in the lumbosacral region. Malformations did not occur in the cervical spine or the basilar part of the occipital bone, but the postsphenoidal part of the sphenoid bone was small and irregular in the six cases where it could be examined. In seven fetuses there was malformation or agenesis of the nasal bone. This pattern of axial skeletal malformations in trisomy 13 fetuses was not described previously. Comparisons are made with previous studies of the fetal axial skeleton in trisomy 18 and trisomy 21, where the pattern of malformations was different. We reiterate our recommendation that axial skeletal radiography should be part of the postmortem examination of fetuses with suspected or verified chromosome abnormalities.

Abnormalities, Multiple↗
PubMed1996

The human vomeronasal organ: prenatal developmental stages and distribution of luteinizing hormone-releasing hormone.

The purpose of this study was to describe in 49 normal human prenatal specimens, 15-156 mm crown-rump length (CRL), the histomorphological development of the bilateral vomeronasal organ localized in the mucosa of the nasal septum. In addition, immunohistochemical localization of luteinizing hormone-releasing hormone (LHRH) was undertaken. The material was classified into five developmental stages (NAS I/V), based on the morphology of the nasal cavity. The vomeronasal organ was visible in stages NAS II, III and IV, corresponding to 21-102 mm CRL. Positive immunohistochemical reaction for LHRH neurons was pronounced in the vomeronasal organ in NAS II and III, corresponding approximately to fetal ages 8-12 gestational weeks (21-51 mm CRL). The study demonstrates in normal human prenatal material that LHRH can be recorded in the bilateral vomeronasal organs during approximately 4 weeks of intrauterine life.

Crown-Rump Length↗
PubMed1994

Management of Peutz-Jeghers syndrome. Experience with patients from the Danish Polyposis Register.

Danish patients with Peutz-Jeghers syndrome are registered in the Danish Polyposis Register. We have initiated a new follow-up programme based on recent literature including our own cases. This has been adjusted to the regrowth rate of the polyps whereby patients with no symptoms and low regrowth rate are followed with few examinations. The programme includes upper and lower gastrointestinal endoscopy, small bowel enema and in cases with large or symptomatic polyps, laparotomy with intraoperative total enteroscopy with polypectomy as required. Pelvic examination, cervical smear, breast and testicular examination are carried out after the age of 30 years.

Adolescent↗
PubMed1992

Prevalence of antibodies against heat-stable antigens from Helicobacter pylori in patients with dyspeptic symptoms and normal persons.

Heat-stable antigens from Helicobacter pylori were investigated for the detection of serum IgG, IgA and IgM antibodies against H. pylori by an ELISA technique. Antibody titers against H. pylori were measured in 167 dyspeptic patients, of whom 96 were H. pylori positive confirmed by culture or microscopy, and in 482 controls (0-98 years). Increased IgG antibody titers were found significantly more often in dyspeptic patients with active chronic gastritis than in patients with normal morphology, as well as in H. pylori-positive patients as compared to H. pylori-negative patients, independent of the endoscopic findings. The heat-stable antigens were compared with acid glycine-extracted antigens and a high degree of concordance was found in the results obtained with the two antigen preparations. The differences in the IgA antibody titers against H. pylori between H. pylori-positive and H. pylori-negative dyspeptic patients were significant and may be useful to confirm a borderline IgG result. No differences were found in IgM antibody titer between H. pylori-positive and -negative patients. The greatest age-dependent increase in IgG and IgA antibody titers was found in children, and if a lower cut-off level is used for children than for adults, as has been proposed, the proportion of people with increased antibody titers against H. pylori would be almost constant from the age of between five and 10 years until the time between 61 and 80 years. Comparison of H. pylori IgG antibodies with IgG antibodies against Campylobacter jejuni and total antibodies against cytomegalovirus (CMV) showed a greater similarity between H. pylori and C. jejuni (R = 0.51) than between H. pylori and CMV (R = 0.22). This may possibly be caused by cross-reactions between H. pylori and C. jejuni. The H. pylori heat-stabile antigen seems not to be very different from other crude H. pylori antigens like acid glycine-extracted antigens, but purification and characterization of the antigens are needed to improve antibody assays.

Adolescent↗
PubMed1983

Myocardial preservation during anoxic arrest. Chemical cardioplegia.

Two types of cardioplegic solution--the potassium arrest and the Bretschneider solution, both at 4 degrees C--were compared with regard to protective effect against ischemic damage during 60 min of anoxic cardiac arrest in the dog heart. Both solutions provided equally good protection, which was superior to that given by hypothermia alone.

Animals↗
PubMed1983

Myocardial preservation during anoxic arrest. Premedication with propranolol, verapamil or methylprednisolone.

Anoxic cardiac arrest was studied for one hour in five groups of dogs. Groups I-III were given methylprednisolone (30 mg/kg b.w.) before aortic cross-clamping. Normothermia was used with electrically induced ventricular fibrillation in group I, and without such fibrillation in group II, while group III was studied in local hypothermia. Propranolol (10 micrograms/kg) was given to group IV and verapamil (0.2 mg/kg) to group V before the anoxic arrest in local hypothermia. Judged from the ability of the heart to take over the circulation after anoxic arrest, local cooling preceded by propranolol or verapamil gave working performance comparable with the pre-arrest values. In the cooled, steroid-pretreated hearts the work capacity was depressed to the same degree as in locally cooled hearts without steroid premedication. Methylprednisolone prevented ischemic contracture during normothermic arrest with induced fibrillation, but not in the absence of such fibrillation. As adjuvant to local cooling, pretreatment with metabolism-reducing drugs is favorable for cardiac performance after arrest. Steroid premedication should be considered when normothermic arrest with electrically induced ventricular fibrillation is planned.

Animals↗
PubMedDate not supplied

Normal prenatal development of the human parietal bone and interparietal suture.

This study describes the prenatal human parietal bone development and interparietal suture morphology under normal conditions. The human fetal material consisted of 15 normal specimens, derived from spontaneous and therapeutically induced abortions. The study was based upon a radiographic analysis of the calvariae. Special attention was paid to the parietal tuber area, the interparietal (sagittal) suture and the frontal-parietal bone edge. The osseous morphology of these regions showed a well-defined primary ossification center at the tuber region from where bone trabeculae of uniform size and radiopacity radiated. The uniform trabeculae radiate at nearly right angles to the long axis of the sagittal suture. The bony trabeculae radiate uniformly towards the anterior fontanelle where at the peripheral border of the parietal bone radiopaque, transverse ossification corpora were observed. In the small fetuses, these corpora were located anterior to the trabeculae and in the larger fetuses close to the trabeculae. Insight into the morphological pattern in normal suture formation is essential for the further description of pathological suture morphology and for understanding normal and pathological suture development.

Cranial Sutures↗
PubMedDate not supplied

The association between prenatal sella turcica morphology and notochordal remnants in the dorsum sellae.

The purpose of this study was to describe the location and morphology of notochordal remnants in the cranial base in normal and pathological conditions and to relate these findings to the morphological appearance of the sella turcica. Serially cut sagittal sections of paraffin-embedded sella turcica tissue blocks from 88 normal and pathological fetuses, 13 to 24 weeks of gestation, were examined. Twenty-seven specimens out of 88 had visible notochordal remnants in the cranial base, and these constituted the material available for this study. A straight notochordal course is always seen in normal sella turcica morphology, and a non-straight notochordal course is always seen in malformed sella turcica. Among the fetuses diagnosed at autopsy as "normal fetuses," both normal and pathological findings in the sella turcica regions were observed. The pathological findings were always found in the spontaneously aborted fetuses (five cases). Among the fetuses diagnosed at autopsy as "pathological fetuses," both normal and pathological findings were also observed in the sella region. Our conclusion is that the morphological appearance of the notochordal remnants in the dorsum sellae is associated with the morphology of the sella turcica. These structures ought to be analyzed on larger materials of both normal and pathological fetuses. One of the more obvious perspectives opened up by the present study is the probable disclosure of malformations in spontaneously aborted fetuses without external malformations.

Female↗