Effects of water soluble splenic extracts on intestinal smooth muscle.
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Biomedical subjects
Publications and source records attributed to B Fernández.
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During the first six months of 1970 we collected 16 lots of the bivalve Anadara tuberculosa from two areas within the Gulf of Nicoya, Costa Rica. These were examined bacteriologically and the coliform levels found in all of them were such that they had to be graded as not satisfactory for human consumption, according to generally accepted norms. The source of these coliforms is attributed to the sewage discharge of the city of Puntarenas into its estuary.
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pKa's of fourteen beta-receptor blockers, isoproterenol and norepinephrine, were determined potentiometrically. A Hammett analysis indicated that the influence of ring substituents on the basicity of the amines is attenuated by the ethanolic chain and abolished by the propranoloxy chain of beta-receptor blockers. The effect of ring substituents in phenoxypropranolamines upon affinity for the beta-adrengeric receptors is therefore unrelated to the strength of the bases. Two alterantive hypotheses are fowarded to explain why phenoxypropranolamines have greater affinities for the beta-receptors than phenethanolamines.
The effect of cortisol on the levels of free and sterified cholesterol in the livers of normal and adrenectomized rats has been studied. The results indicate that cortisol enhances those lipids in plasma and decreases their level in the liver.
Adrenalectomy and/or cortisol-induced variations in the in vivo and in vitro incorporation of 14C-palmitic acid 1 into the different fractions of rat liver lipids were studied. The different fatty acids incorporations follow analogous patterns in every hormonal state in vitro. Incorporation rate is faster in normal animals, but adrenalectomy or the administration of cortisol produces a marded delay. Cortisol does not modify the anomalism observed in the adrenoprival state. In vivo, the incorporation of palmitic acid into the different liver lipids--for the same hormonal state--does not follow the same pattern.
The hepatic concentration of triglycerides, free fatty acids and total lipids was determined in four groups of rats: normals, adrenectomized and normal and adrenectomized previously treated with cortisol, 30 mg. In chronic adrenectomized state, total lipids and hepatic triglycerides are diminished, particularly the triglycerides. Adrenectomy does not appear to have significative effect on the free fatty acids. The administration of cortisol does not change those observations and, when given to normal animals, decreases the hepatic concentrations of free fatty acids, triglycerides and total lipids.