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Biomedical subjects

B Farkas

Publications and source records attributed to B Farkas.

51 records · Page 3Linked to original sources
PubMed1981

Part I Clinical overview of the management and fitting of the extended wear patient.

With the advent of extended wear contact lenses, new potential benefits, risk and responsibilities have come into existence for contact lens patients and practitioners alike. Without a careful, thorough and systematic clinical approach, the practitioner will find himself experiencing only the pitfalls without enjoying the possible benefits. This paper will attempt to present such a clinical approach, emphasizing a deductive and holistic approach to extended wear lens fitting. Previous clinical and laboratory work will be reviewed as it pertains to this presentation. Through the use of a thorough case history and diagnostic evaluation, patients can be effectively screened and counseled as to their acceptability and selection into an extended wear lens program. Mutual patient and a doctor goals must be established and be compatible. Subsequent contact lens selection and patient management will be discussed as they relate to the fulfillment of these goals. Commonly found complications with extended wear of contact lenses will be reviewed as they pertain to both the lenses and the ocular structures. Methods of management of these complications will be discussed.

Adolescent↗
PubMed1975

[Early and late results after Colonna arthroplasties of the hip-joint (author's transl)].

In 10 years the authors have carried out 107 Colonna arthroplasties of the hip-joint. Results could be followed up in 98 patients, of whom 56 were - at the time of operation-less than 5-year-old, 42 holder. Among the early operations results were good and satisfactory in 60 per cent, in the late operations 50 per cent. They found that the quality of the result depended largely on the age of the patient, pre-operative traction and additional osteotomy. They recommend this operation for patients with neglected CDH or for those in whom closed reduction did not succeed and operations after Pemberton or Salter cannot be carried out any more.

Age Factors↗
PubMedDate not supplied

Long-term post-treatment follow-up of onychomycosis treated with terbinafine: a multicentre trial.

Between 1991 and 1993, 32 cases of fingernail mycosis and 20 cases of toenail mycosis caused by dermatophytes were treated with terbinafine. For 8 weeks, 250 mg of terbinafine was given daily for fingernail infections, and for 12 weeks the same dose was given for toenail involvement; the short-term follow-up was 24 and 48 weeks respectively. A long-term follow-up was performed twice, initially at 24 and then at 48 months after the end of the treatment. For fingernail mycosis, the mycological cure rate was 100% at the end of month 24 and 91% at the end of month 48. Mycological cultures gave negative results in toenail infections in 90% after 24 months and in 86% after 48 months. After 24 months, 23 out of 26 patients (88%) with fingernail and 17 out of 20 patients (95%) with toenail mycosis were clinically cured. After 48 months, 20 out of 22 cases (91%) with fingernail and 10 out of 14 cases (71%) with toenail involvement showed a complete cure.

Adult↗
PubMedDate not supplied

Immunoglobulins in tears and sera in patients with atopic dermatitis.

The aim of the study was to investigate the role of circulating (i.e., present in the serum) and locally produced (i.e., in the lamina propria of mucous membranes) immunoglobulins including IgE. The IgG, IgA, IgM immunoglobulins, and IgE (total and specific) were measured in patients' sera with atopic dermatitis (AD) (n = 93). As control subjects 83 healthy volunteers, matched for sex and age, were included. The IgG and IgM levels were within the normal range. Mean value of the total IgA (2.55 +/- 0.26 g/L, in controls 1.49 +/- 0.32 g/L) and IgE (609 IU/mL, in controls below 40 IU/mL) levels were significantly elevated (p < 0.05) in sera of AD patients. Based on the serum total IgE levels (above or below 40 IU/mL) the patients were divided into RAST-positive and RAST-negative types of allergy, respectively. RAST-positive AD (n = 79) showed hypersensitivity to inhalant and food allergens determined by the specific IgE test. The majority of RAST-positive AD cases (n = 68) presented only skin manifestations, while the rest of the patients (n = 11) had rhinoconjunctivitis as well. RAST-positive AD patients with rhinoconjunctivitis showed an increased IgE level in tears (above 10 IU/mL). The specific IgE test positivity in tears correlated with elevated serum total IgE levels and specific IgE positivity (r = 0.925). Total and allergen-specific IgE in the tears can be used to diagnose allergy in vitro. It is believed that the mucosal permeability is enhanced in the atopic inflammatory process, and this may facilitate the transmission of environmental allergens.

Adolescent↗
PubMedDate not supplied

Cancer protection in xeroderma pigmentosum variant (XP-V).

We describe herein a brother and sister diagnosed with xeroderma pigmentosum variant (XP-V) in early adult life, who presented with increased sensitivity to sunlight and with cutaneous carcinomas on sun-damaged skin. The 27-year-old male farmer (Case 1.) was diagnosed with advanced squamous cell carcinoma (SCC) and multiple actinic lesions. Surgical removal of these lesions was performed. Three months later he died of multiple pelvic metastases of SCC. His 29-year-old sister (Case 2.) was operated on for different tumors, histologically SCC-s or basal cell carcinomas (BCC), or praecancerous conditions many times. After a two year interval she was treated with low dose isotretinoin (2 mg/body weight). Diagnosis of XP-V was based on unscheduled DNA analysis (USD) and on clinical symptoms. We observed that during the long lasting isotretinoin treatment the tumor frequency dropped to a quarter. Therefore, the isotretinoin treatment seems to be a good approach for cancer prevention in conditions with high predisposition to skin cancer, such as in XP-V.

Adult↗
PubMedDate not supplied

Immunomodulatory treatment with low-dose interferon-alpha and oral retinoic acid in lymphangioma-like Kaposi's sarcoma.

BACKGROUND: The presence of lymphangiectasis without the characteristic spindle cell proliferation may lead to diagnostic difficulties in Kaposi's sarcoma. Although the literary data mention that the lymphangioma-like tumors may occur in Kaposi's sarcoma, there have been few specific reports and case presentations published. OBSERVATIONS: A case of lymphangioma-like Kaposi's sarcoma in association with IgG/lambda type paraproteinaemia is reported in a 60-year-old man. The HSV8 DNA sequence could be detected by PCR analysis from lesional skin. CONCLUSION: The beneficial effect of alpha-2 interferon (4.5 million units per week) combined with retinoic treatment (0.5 mg/body weight of isotretinoin) caused the regression of the skin rashes while improving the values of immunological tests (T cell function, quantity of paraproteins). The patient's improved general condition and the ameliorating immunological parameters were due to the combination of two regimens applied in a low-dose the alpha-2 interferon (tumor regression) and the oral isotretinoid (antitumor activity, reduction of IL-6 receptor display) treatment.

Adjuvants, Immunologic↗
PubMedDate not supplied

Disposable hydrogel contact lenses for extended wear.

Nine ophthalmologists and nine optometrists conducted a premarket study of the Acuvue disposable contact lens manufactured by Vistakon, Inc. Of the 812 patients offered the lens, 733 accepted it and were enrolled in the study. These patients were fitted with the lens and followed for a period of 8 months. Over 98% of these patients had 20/25 or better vision on initial fitting; and subjective ratings of lens comfort were very good. Only 3.7% (27 of 733) discontinued wearing their lenses during the study period. Thirty-four patients (5.6%) experienced a problem while wearing their contact lenses.

Adolescent↗