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B F Waller

Publications and source records attributed to B F Waller.

203 records · Page 12Linked to original sources

Pathology of the cardiomyopathies.

The following article reviews the anatomic and pathologic basis of various cardiomyopathies and illustrates the dilated, hypertrophic, and restrictive types in various echocardiographic planes. Two types of cardiomyopathy are defined: (1) heart muscle disease of unknown cause (idiopathic, primary) and (2) heart muscle disease of known cause or associated with disorders of other organ systems (secondary). Of the cardiomyopathies of unknown cause, the dilated type is the most common. The anatomic diagnosis of hypertrophic cardiomyopathy is based on several morphologic features, the most important of which are asymmetric septal hypertrophy, small left ventricular cavity, and myocardial fiber disarray. Endomyocardial fibrosis with or without peripheral eosinophilia represents the unknown type of restrictive or obliterative form of cardiomyopathy. Selective specific heart muscle diseases (amyloid, iron, myocarditis, toxic, storage disease) are briefly reviewed.

Cardiomyopathies↗

Anatomy, histology, and pathology of the major epicardial coronary arteries relevant to echocardiographic imaging techniques.

We are at the threshold of a new era of coronary artery imaging with the use of transthoracic, transesophageal, and intravascular ultrasound. Echocardiographic imaging has the capability of assessing changes of the lumen and walls of major epicardial coronary arteries. This article reviews certain anatomic, histologic, and pathologic observations of the major epicardial coronary arteries relevant to these various echocardiographic imaging techniques.

Coronary Artery Disease↗

Healing after arterial dilatation with radiofrequency thermal and nonthermal balloon angioplasty systems.

Thermal balloon angioplasty has been proposed as a means of reducing acute and delayed reclosure of arteries after percutaneous transluminal balloon angioplasty. A radiofrequency (rf) balloon catheter was used to perform thermal balloon angioplasty on canine arteries in vivo. The histologic appearance of rf-treated sites was compared with that of control sites treated by conventional percutaneous transluminal angioplasty. Acutely, rf-treated sites showed a reduced medial cellularity with preservation of internal elastic lamina except at the transitional zone between thermal injury and normal artery, where localized internal elastic lamina disruption was found. Nonthermal sites showed generalized disruption of internal elastic lamina and normal medial cellularity. Both thermal and nonthermal sites displayed a return of intimal cover commencing at 1 to 2 weeks and completed by 4 weeks. Diffuse myointimal hyperplasia appeared by 2 weeks after injury at breaks in the internal elastic lamina along the nonthermal vessels but was localized to the transitional zone in thermal injury sites. In rf-treated vessels, repopulation of the acellular thermally modified media had commenced by 4 weeks, and by 8 weeks the media was diffusely repopulated by spindle-shaped cells resembling smooth muscle cells lying between and aligned with preserved connective tissue laminae. Overall, the distribution and extent of the proliferative response after rf thermal balloon angioplasty were less than those seen after nonthermal balloon angioplasty. Thermal sites, which underwent reintimalization before medial cells returned, were considerably less prone to the development of myointimal hyperplasia. These results suggest that this modality may have beneficial effects on arterial healing after angioplasty.

Angiography↗