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Biomedical subjects

B F Robinson

Publications and source records attributed to B F Robinson.

71 records · Page 4Linked to original sources
PubMed1969

Mechanism of action of beta-adrenergic receptor blocking agents in angina pectoris: comparison of action of propranolol with dexpropranolol and practolol.

The effect on exercise tolerance of racemic propranolol has been assessed in eight angina pectoris patients and compared with that of dexpropranolol (the dextro isomer of propranolol), practolol (I.C.I. 50172), and saline. Dexpropranolol has the same local anaesthetic action as propranolol with negligible beta-adrenergic receptor blocking activity, while practolol is a cardio-selective beta-adrenergic blocking agent which does not have local anaesthetic activity.Saline and dexpropranolol had no significant effect on exercise time; racemic propranolol and practolol improved exercise tolerance in six subjects, the response to the two drugs being very similar in individual patients. It was concluded that the beneficial effect of propranolol in angina pectoris results from its action as a beta-adrenergic receptor blocking agent and is not due to its local anaesthetic, or quinidine-like, activity.

Acetanilides↗
PubMed1966

Effect of sympathomimetic compounds with beta-adrenergic effects on plasma free fatty acids in man.

Nine sympathomimetic compounds were infused intravenously in man, and their effects on the level of plasma free fatty acids, pulse rate, and blood pressure were recorded. Each compound raised the level of plasma free fatty acids. Its activity in this respect could be correlated with its activity in producing Beta-adrenergic effects on the circulation; both effects were abolished by pretreatment with propranolol. It is concluded that sympathomimetic compounds that stimulate -receptors will raise the plasma concentration of free fatty acids.

Fatty Acids↗
PubMedDate not supplied

Long-term efficacy of calcium antagonists in resistant hypertension.

Verapamil and nifedipine are calcium-blocking agents that have a selective dilator effect on resistance vessels. Both drugs have been shown to lower arterial pressure when given in long-term therapy under conditions of a double-blind controlled trial. Both agents may be effective as sole therapy or when given in combination with a diuretic; nifedipine has been used successfully in conjunction with beta-adrenoceptor antagonist/diuretic combinations. Calcium-blocking agents do not evoke tolerance in long-term treatment; in contrast to other directly acting dilator drugs, they do not consistently lead to a rise in plasma renin activity and they induce little or no sodium retention. Calcium-blocking agents do not all share the same mechanism of action, and they vary considerably in their effect on the heart. These differences may be important in determining which compound is best suited for use in particular clinical situations.

Antihypertensive Agents↗