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Biomedical subjects

B F McCabe

Publications and source records attributed to B F McCabe.

At least 127 records · Page 7Linked to original sources
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ENG of the month.

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Aged↗
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Characterization of tumor antigen in epidermoid carcinoma.

Tumor antigens have been isolated from nine epidermoid carcinomas of the head and neck. The most strongly reactive antigens have a molecular weight of congruent to 25,000-50,000 daltons, though other antigens weighing congruent to 120,000-400,000 daltons were noted in six of the tumors. The most strongly reactive antigens had a pI between 8.36 and 8.40. The cross reactivity of these antigens will be studied next. It is hoped that the purified tumor antigen will be useful in the development of an immunodetection system for epidermoid carcinoma.

Antibodies, Neoplasm↗
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Preservation of cochlear function after extensive labyrinthine destruction.

Four ears are presented with extensive destruction of the bony and membranous labyrinth with the loss of caloric function but with retention of hearing. Fourteen similar cases described previously in the literature are reviewed. Our cases are unique in that hearing was preserved after surgical removal of the disease in the inner ear itself. We are unaware of any previous well-documented reports showing such extensive destruction of the pars superior portion of the labyrinth with the preservation of hearing. Possible explanations and theoretical implications are discussed.

Adult↗
PubMedDate not supplied

Limitations of parotid scans.

In 1967, Gates and Work proposed techentium scanning as a diagnostic tool for salivary neoplasms. Since then, many publications have dealt with the results of scanning. The impression has been that it has certain diagnostic implications, especially in regard to the lesions which is radiopositive on the scan. A review of 29 salivary scans from the University of Iowa Hospitals was carried out, and the conclusion reached was that nuclear scanning using technetium gave little assurance of a specific histological entity in any individual case. Cases having both cold and hot nodules ran the gamut from benign and nonneoplastic to frankly malignant lesions. These cases are illustrated, and the conclusion is reached that salivary scanning at its present stage of development may only delay the proper diagnostic step of excisional (at least lateral lobectomy) biopsy for all nondiffuse parotid mass lesions.

Adenolymphoma↗
PubMedDate not supplied

The problem of the collapsing upper lateral cartilage.

The collapsing upper lateral cartilage is an airway problem that admits to no ready solution, such as the deviated nasal septum or deflected columella. It is my understanding from experienced nasal surgeons that an attack directly on the upper lateral cartilage has not provided a solution, but in general makes the problem worse. A look at the nasal septal base by simultaneous viewing of both nasal chambers may reveal a dimenionsal of 1 cm or more. In that event, a fairly radical narrowing of the septal base in the plane of the pyriform crest by a subperiosteal and subperichondrial approach with well-placed transfixion sutures can increase the air-flow across that plane. It has done so in eight patients. This operation is for the experienced nasal surgeon, or the otolaryngologist who has prepared himself by careful cadaver preexperience.

Airway Obstruction↗
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Autoimmune sensorineural hearing loss.

The author proposes the existence of a new entity, autoimmune sensorineural hearing loss, on the basis of diagnostic study and treatment experience with a series of 18 patients. In each case the clinical pattern did not fit with known entities and thus seemed to merit distinctive categorization. In the one patient in whom tissue was available, a vasculitis was evident, a feature of autoimmune disease. All patients responded to treatment for an autoimmune disease, namely, chronic cortisone and cyclophosphamide therapy. The author suggests that all otolaryngologists should be aware of the possibility of this condition, because it is one of the few forms of sensorineural deafness for which we have a treatment.

Adult↗
PubMedDate not supplied

Effects of attention-requiring tasks on vestibular nystagmus.

The purpose of this investigation was to determine the influence of two types of attention-requiring tasks on vestibular nystagmus elicited by caloric stimulation: mental arithmetic and a short conversation. The subjects were divided into four groups according to stimulus paradigm and task. It was found that conversation was consistently superior to mental arithmetic in engaging the cortex and preventing response decline and even reverse caloric-induced habituation.

Adult↗
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Second-order vestibular adaptation and cupular dynamics.

The magnitude of initial response and slope of continued response of 45 neurons in the vestibular nuclei of cats to constant and interrupted accelerations were investigated. Eighty-eight percent exhibited adaptation, the magnitude of which was proportional to the stimulus. Comparison of slope and intercept of the response to continuous acceleration before and after a superimposed inhibitory velocity change suggests that the adaptation phenomenon is unrelated to cupular position.

Acceleration↗
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Voice button prosthesis rehabilitation of the laryngectomee. Additional notes.

Forty laryngectomy patients in Iowa have received a tracheoesophageal fistula and voice button prosthesis. The fistula was successfully completed in all patients using local anesthesia. Delayed insertion of the voice prosthesis, approximately a month after the fistula is created, appears to be helpful in establishing the respiratory muscle control needed to achieve tracheoesophageal speech. In addition, delayed insertion allows for longer fistula maturation, recognition by the patient that speech is formed by vibrations within the pharyngoesophageal segment, and improved ability to manage the fistula site by proper insertion of the stent. The tracheoesophageal fistula-voice button prosthesis technique has proved to be a relatively simple, uncomplicated, reproducible and inexpensive method of achieving effective speech in a majority of laryngectomy patients.

Esophagus↗
PubMedDate not supplied

The giant apical air cell syndrome. A new entity.

A new entity, the giant apical air cell syndrome, is presented and its surgical management is described. The syndrome triad consists of a giant apical air cell, spontaneous CSF rhinorrhea, and recurrent meningitis. Constant pounding of the brain against the dura overlying the giant air cell eventually, cause dural rupture and CSF leak. The giant apical air cell communicates with the eustachian tube creating a direct route for CSF to leak from the subarachnoid space into the nasopharynx. The syndrome is best diagnosed by polytomography of the petrous apex, surgical exploration, and careful dissection using the operating microscope. Dye or contrast studies are no longer necessary. Extracranial surgical management is preferable to the intracranial approach. Tympanomastoidectomy is performed with obliteration of the eustachian tube, middle ear, and mastoid. In this manner, the subarachnoid space is separated from the nasopharynx, preventing further episodes of meningitis. A detailed knowledge of the regional anatomy and the application of basic surgical principles should enable the temporal bone surgeon to accurately diagnose and manage most CSF fistulae.

Adult↗