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Biomedical subjects

B Eckert

Publications and source records attributed to B Eckert.

45 records · Page 3Linked to original sources
PubMed1989

Overproduction of transposon Tn10-encoded tetracycline resistance protein results in cell death and loss of membrane potential.

High-level expression of the Tn10 tetracycline resistance protein TetA in Escherichia coli caused partial collapse of the membrane potential, arrest of growth, and killing of the cells. Since alpha-methylglucoside transport was not affected, the overproduced TetA protein may cause not destruction of membrane structure but rather unrestricted translocation of protons and/or ions across the membrane.

Bacterial Proteins↗
PubMed1986

Effect of streptokinase on fibrinogen and related proteins in plasma.

We investigated the effect of streptokinase on determination of fibrinogen and related clottable proteins in an effort to assess the relative reliability of these determinations in monitoring patients being treated with streptokinase. Citrated plasma was incubated with and without streptokinase, then assayed for fibrinogen (I), fibrin(ogen) degradation products (II), total clottable protein (III), and plasminogen (IV). Values for I decreased rapidly. Values for III and IV generally paralleled those for I, values for III lacked adequate sensitivity. II, low initially, increased to 80 mg/L in 1-2 h. Soybean trypsin inhibitor effectively stabilized all these constituents (except IV) in streptokinase-treated plasma, and we recommend that this (or some other such) inhibitor of fibrinolysis be used routinely when specimens are collected for these determinations. Data are presented that suggest that transient polymers are formed, the clinical significance of which is not known.

Blood Coagulation Tests↗
PubMed1982

The activity of monoamine oxidases A and B in gamma-irradiated rabbit brains.

The activities of monoamine oxidases A and B towards 5-hydroxytryptamine and beta-phenethylamine, respectively, were compared in the left and right caudatus, hippocampus, parietal cortex, cerebellum and frontal cortex 6 months after gamma-irradiation (single dose of 23 Gy) of either the right hemisphere or of the whole rabbit brain (in which case, a dose of l6 Gy). No difference in monoamine oxidase A or B activities were found in any of the brain regions.

Animals↗
PubMed1977

Monoamine oxidase activity in gamma-irradiated rat brains.

The short-term effect of gamma-irradiation (single dose, 100 Gy = 10 000 rad) on tth monoamine oxidase activity in the rat brain was investigated. In contrast to other investigations virtually no changes in MAO-activity were found.

Animals↗
PubMedDate not supplied

Irreversible progression of severe retinopathy in young type I insulin-dependent diabetes mellitus patients after improved metabolic control.

The impact of metabolic control on the development of rapidly progressive severe retinopathy was studied in 14 young type I insulin-dependent diabetes mellitus (IDDM) patients. Glycosylated hemoglobin (HbAlc) levels 45 months prior to and 12 months after the diagnosis of retinopathy were compared with HbAlc levels in 17 type I IDDM patients with no or minimal background retinopathy, matched for age and duration of diabetes. HbAlc levels were generally higher in patients with severe retinopathy (p less than 0.05) from 39 months until 6 months before the diagnosis of retinopathy. Thereafter, there was a gradual decrease in HbAlc levels reaching the same level as in control patients 6 months after diagnosis of retinopathy. Patients with severe retinopathy required higher doses of insulin prior to the diagnosis of retinopathy (p less than 0.05), but the insulin requirement decreased, and 12 months afterward, the insulin dosage was similar to patients with background retinopathy. Systolic blood pressure levels were slightly increased and higher in patients with severe retinopathy compared with control patients from 18 months before to diagnosis of retinopathy (p less than 0.05). Diastolic blood pressure levels likewise differed at 18 and 12 months before and at the time of diagnosis of retinopathy as well as 12 months afterward (p less than 0.05); however, no differences were seen in urinary albumin or serum creatinine levels between the groups. Thus, years of poor metabolic control, drastically improved, preceded the development of irreversible severe retinopathy in these young type I IDDM patients.

Adult↗
PubMedDate not supplied

Clinical and ultrasonic long-term results of percutaneous transluminal carotid angioplasty. A prospective follow-up of 30 carotid angioplasties.

Experience of the long-term outcome of patients treated with carotid balloon angioplasty is limited. Therefore, we prospectively analyzed the ultrasonic and clinical features of 29 patients with complete follow-up data beyond 24 months, evaluated from 1989 through 1996 from our carotid angioplasty cohort of 106 patients. Mean follow-up time was 33 months. For up to 78 months postangioplasty, 23 patients with 24 angioplasties (77%) had no further neurological sequelae. Single ipsilateral amaurosis fugax or TIA events occurred in 3 patients. Recurrent ipsilateral amaurosis fugax or TIA events were noted twice in 2 patients. No patient suffered an ipsilateral stroke. Fifteen angioplasties (50%) remained with normal ultrasound (stenosis < 50%), mild restenosis (50-70%) occurred in 12 angioplasties (40%), and severe restenosis (> 70%) in 3 angioplasties (10%). Only in 2 of 15 patients clinical complications were related to the occurrence of ipsilateral restenosis above 50%. Until now, rigorous and careful evaluation of patients and clinical and ultrasonic follow-up have been essential for the estimation of the long-term efficacy of carotid angioplasty. It should be noted that carotid angioplasty is a new technique in evolution, with a high potential improving the technical results.

Aged↗