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Biomedical subjects

B E Hirsch

Publications and source records attributed to B E Hirsch.

82 records · Page 5Linked to original sources
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New-onset atrial fibrillation: is there need for emergent hospitalization?

Patients with new-onset atrial fibrillation are often hospitalized emergently. To determine whether this is necessary, the authors retrospectively reviewed the care of 97 consecutive patients with this illness. No reason for the atrial fibrillation in 43 patients could be identified. Hypertension, coronary artery disease, and valvular heart disease were the most commonly associated conditions; myocardial infarction occurred in one patient. In 82% of patients, atrial fibrillation reverted to normal sinus rhythm during hospitalization. Three patients needed emergent hospitalization irrespective of the presence of atrial fibrillation. In the remainder, admission was based solely on the diagnosis of new-onset atrial fibrillation. Ninety-eight per cent had an uncomplicated hospital course. It is concluded that hospitalization is not necessary for all patients with new-onset atrial fibrillation. Those in whom reversion to normal sinus rhythm occurs rapidly during digoxin therapy can be discharged. Where no major medical illness is evident patients can be admitted to a bed outside the intensive care unit until reversion to normal sinus rhythm or rate control is achieved.

Adult↗
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Preservation of vestibular nerves in surgery of the cerebellopontine angle: effect on hearing and balance function.

INTRODUCTION: Small tumors of the cerebellopontine angle (CPA) can frequently be removed with preservation of the auditory and the vestibular portion of the eighth cranial nerve. This study was undertaken to estimate the effect of vestibular nerve preservation on both balance and hearing following surgery. MATERIALS AND METHODS: A retrospective study of all cases of CPA lesions between 1987 and 1991 was undertaken. This identified 11 patients in whom either the superior and/or inferior vestibular nerves were preserved. This included eight acoustic neuromas and three meningiomas. The retrosigmoid approach and total tumor extirpation was undertaken in all cases. Patients undertook a vestibular questionnaire, audiometric testing, and evaluation of vestibulo-ocular responses preoperatively and postoperatively. Additionally, static and dynamic platform posturography was performed postoperatively in 9 of 11 patients. RESULTS: Follow-up ranged from 6 to 44 months. Of the eight patients with acoustic neuroma, four had a preoperative balance disorder that resolved postoperatively. One patient died of unrelated causes. Of the remaining seven patients with caloric testings, one maintained normal caloric responses. A persistent postoperative phase shift was noted in 4 of the 7 cases with rotatory testing. Three patients were treated for a meningioma. All had a preoperative balance disorder that resolved postoperatively. Two patients showed vestibular response indicative of residual but compromised function on the involved side. The third patient showed absent responses indicating an anatomically intact nerve that does not necessarily predict functional activity. Preservation of the vestibular nerve was associated with preservation of preoperative hearing in five of the patients. This included four of the eight acoustic patients and one of the three meningioma patients. CONCLUSIONS: Preservation of the vestibular nerve did not result in a chronic balance disorder in this patient population. This study does not allow the authors to conclude if vestibular nerve preservation improves overall hearing after CPA surgery; however, these data suggest that preservation of the inferior vestibular nerve may result in less damage to the cochlear nerve in some patients. Accordingly, preservation of the vestibular nerve in CPA meningioma surgery can be recommended.

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PubMedDate not supplied

Hypercoagulability in otologic patients.

INTRODUCTION: Three patients with otologic disorders developed complications related to hypercoagulability. This report was prepared to increase the awareness among otolaryngologists of the diagnosis and management of hypercoagulable states, and to encourage expert consultation when indicated. MATERIALS AND METHODS: One patient with dural venous sinus thrombosis complicating an otitis media, one patient with a large glomus jugulare tumor, and one patient with a sudden sensorineural hearing loss were treated by the otolaryngology service. Suspicious thromboembolic events were evaluated by the hematology service, and appropriate anticoagulative therapy was recommended. RESULTS: One patient with an inherited hypercoagulopathy and two patients with acquired hypercoagulopathies were treated for otologic problems. Two of the patients were stabilized and discharged on life-long anticoagulation therapy. The third patient, in spite of intensive medical and surgical support, eventually succumbed to complications to which an acquired hypercoagulable state made a significant contribution. Expert consultants made the hematologic diagnoses and treatment recommendations. CONCLUSION: Otolaryngologists should be aware that hypercoagulable states may now be more accurately diagnosed and characterized, and that thorough investigation of thromboembolic events may affect treatment decisions.

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3D MR image analysis of the morphology of the rear foot: application to classification of bones.

The purpose of this work is to characterize the three-dimensional (3D) morphology of the bones of the rear foot using MR image data. It has two sub-aims: (i) to study the variability of the various computed architectural measures caused by the subjectivity and variations in the various processing operations; (ii) to study the morphology of the bones included in the peritalar complex. Each image data set utilized in this study consists of sixty sagittal slices of the foot acquired on a 1.5 T commercial GE MR system. The description of the rear foot morphology is based mainly on the principal axes, which represent the inertia axes of the bones, and on the bone surfaces. We use the live-wire method [Falcao AX, Udupa JK, Samarasekera S, Shoba S, Hirsch BE, Lotufo RA. User-steered image segmentation paradigms: live wire and live lane. Proceedings of the Society of Photo-optical Instrumentation Engineers 1996;2710:278-288] for segmenting and forming the surfaces of the bones. In the first part of this work, we focus on the analysis of the dependence of the principal axes system on segmentation and on scan orientation. In the second part, we describe the normal morphology of the rear foot considering the four bones namely calcaneus, cuboid, navicular, and talus, and compare this to a population from the upper Pleistocene. We conclude that this non-invasive method offers a unique tool to characterize the bone morphology in live patients towards the goal of understanding the architecture and kinematics of normal and pathological joints in vivo.

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Paraganglioma of vagal origin.

Vagal paragangliomas are anatomically specific tumors of neuroectodermal origin. The history, embryology, and anatomic classification of these tumors will be reviewed and our present experience with six patients with vagal paragangliomas summarized. All patients had vocal cord dysfunction; various other findings depended upon the extent of the tumor. We found that massive tumors extending rostral to the jugular fossa may be difficult or impossible to distinguish from jugulotympanic paragangliomas.

Adult↗
PubMedDate not supplied

High signal from the otic labyrinth on unenhanced magnetic resonance imaging.

High signal from the otic labyrinth was observed on precontrast MR scan of two patients who presented with sudden hearing loss and vertigo. The authors suggest the possibility that the high signal was caused by hemorrhage but that clinical significance and therapeutic implications of this finding need further study.

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