Biomedical subjects
B E Hardy
Publications and source records attributed to B E Hardy.
Renal function in continent patients after surgical closure of bladder exstrophy.
We assessed the upper urinary tracts and renal function in 22 children who had achieved continence after staged correction of bladder exstrophy. All patients had been followed for an average of 8 years after completion of the reconstructive operation. In 15 patients the upper urinary tract was normal and only 1 of the remaining 7 required surgical correction (transureteroureterostomy) of the residual anomaly. Renal function was normal in all children. We attribute these satisfactory results to careful selection of patients, improved surgical techniques and good postoperative care.
Cryptorchidism in boys with posterior urethral valves.
A review of 207 male children with poterior urethral valves revealed an over-all incidence of cryptorchidism of 12 per cent. This association of cryptorchidism in boys with posterior urethral valves has not been described previously.
Adrenal hemorrhage in neonates: report of 5 cases and review of the literature.
The differential diagosis of masses in the suprarenal area in neonates is discussed in relation to clinical, laboratory and radiologic findings. Neonatal adrenal hemorrhage can be accurately diagnosed clinically. In the neonate neuroblastoma in situ is self-limiting and exploration to exclude it is unnecessary. Operative intervention should be reserved for controlling massive adrenal hemorrhage or if an abscess forms.
Growth in boys and posterior urethral valves. Primary valve resection vs upper tract diversion.
Seventy-four patients with posterior urethral valves were evaluated for long-term growth potential and renal function. In those boy diagnosed and treated within the first year of life, initial treatment by temporary supravesical diversion (prior to valve resection) was associated with better growth potential and renal function than was treatment by primary valve resection alone.
Renal transplantation in patients with bilateral Wilm's tumor.
Review of cases and of published reports of patients with bilateral Wilms' tumor revealed a significantly higher mortality rate in those who had received a renal transplant than in those who had not. The increased mortality is attributed to overwhelming sepsis resulting from chemotherapy, radiotherapy and immunosuppression. Growth of the tumor did not appear to be accelerated by immunosuppression and transplantation.
Renal cell carcinoma in children.
The authors reviewed the records of eight children with renal cell carcinoma and correlated the clinical presentation, pathological and radiologic findings, stage and treatment of the disease with patient survival. Angiography revealed tumours of sparse neovascularity, associated with varied histologic patterns. Patient survival was dependent on the stage of the disease at the time of treatment; treatment of localized disease was effective but of metastatic disease was generally poor. Tumour staging appeared to be the only reliable indicator of prognosis. Children with renal cell carcinoma differ from adults in that a palpable mass in a child does not necessarily indicate that there is metastatic disease.
Urologic aspects of malformations and common abnormalities of the anus and rectum.
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Strictures of the ileal loop.
Intrinsic ileal loop strictures in children are much more common than previously reported. They occur late and are usually clinically silent. Their etilogy is inflammatory rather than ischemic and a local immunosuppressive effect of urine also may play a role. Periodic urography, continued indefinitely, is the only certain method of early detection.
Diagnostic aspects of neonatal ascites: report of 27 cases.
Review of 27 cases of massive ascites found in the first month of life, usually immediately after delivery, revealed a broad spectrum of causes. Seven newborns had urinary ascites, five had bowel disease, three had cardiac arrhythmias, two had liver disease, and one each had toxoplasmosis, ovarian cyst, and chylous ascites. In seven cases the cause was never established. Physical examination, a planned sequence of radiologic examinations, and paracentesis for fluid analysis when necessary are the major steps in differential diagnosis. A systematic approach to the problem is proposed.
Antigenicity of aortic valve allografts.
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In vivo damage to circulating lymphoid cells by alloimmune serum in rats.
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The distribution of 51Cr-labeled syngeneic and allogeneic lymph node cells in the rat.
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