Biomedical subjects
Publications and source records attributed to B E Ehrlich.
The intracellular choline concentration in erythrocytes of manic patients who never had lithium therapy was 3 times the value for normal human subjects. Lithium therapy increased this value to 11 times normal, and the increase began within the first 2 days of lithium therapy. Plasma choline concentration was normal in untreated manic patients and did not change during lithium therapy.
The contribution of four transport pathways to Li+ influx and efflux in human erythrocytes was determined quantitatively, using Li+ concentrations comparable to those found in vivo when Li+ is used as treatment for manic-depressive illness. All pathways were measured simultaneously on each subject's blood sample to avoid possible temporal variations in transport parameters. We found that Li+ efflux is 75% via countertransport and 25% via a leak. The bicarbonate-sensitive pathway accounts for 30% of influx while the remaining 70% is via a leak. The Na+-K+ pump makes no significant contribution to Li+ influx or efflux under physiological conditions. Li+ efflux for a given [Li+]i is 3-5 times the Li+ influx for the same [Li+]o. However, due to interindividual variations in Na+-Li+ counter-transport, Li+ efflux but not influx varies considerably among individuals.
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A new method for Li+ analysis by flameless atomic absorption spectroscopy is several orders of magnitude more sensitive than previous methods. Li+ quantities as small as 1 - 10(-12) mol, or Li+ concentrattions as low as 1 - 10(-8) M, can determined with a coeffient of variation of 2--4%. The same technique can determine approx. 1 - 10(-14) mol of Ca2+ and Mg2+, and approx. 1 - 10(-13) mol of Na+ and K+.
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