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Biomedical subjects

B E Dodd

Publications and source records attributed to B E Dodd.

34 records · Page 2Linked to original sources
PubMed1969

Frequencies of secretors and non-secretors of ABH group substances among 1,000 alcoholic patients.

The ABO blood group and secretor status of 1,000 alcoholic patients has been determined. The patients were drawn from large alcoholic units in the London area together with several small units, including rehabilitation centres, nd 127 were from Aberdeen.The findings have been compared with appropriate controls which take into account the ethnic origin of the patients in the series. A striking disturbance of the secretor/non-secretor ratio among group A patients compared with the controls is observed. There is an increase in group A non-secretors, which is almost exactly balanced by a loss of group A secretors so that the overall frequency of the group A phenotype is not disturbed. It is difficult to find an acceptable explanation for these results.

ABO Blood-Group System↗
PubMedDate not supplied

Red cell PGM1 (phosphoglucomutase) phenotyping by isoelectric focussing and starch gel electrophoresis in cases of disputed paternity in the United Kingdom. An evaluation of the results obtained in 95 cases.

Using two techniques for red cell PGM1 (phosphoglucomutase) phenotyping, namely starch gel electrophoresis and isoelectric focussing, a parallel study has been carried out in 95 paternity cases. The results again confirm the genetic basis for the extended polymorphism revealed by isoelectric focussing. Fifteen men were excluded from paternity on the basis of isoelectric focussing compared with seven excluded by starch gel electrophoresis. This was found to be in good agreement with the predicted increase in exclusion rate that the isoelectric focussing technique for red cell PGM1 provides.

Electrophoresis, Starch Gel↗
PubMedDate not supplied

Observations on the use of an autoanalyser and a manual technique for the detection of the red cell antigens C, D, E, c, K and S in bloodstains.

The results of the detection of the Rh antigens (D, C, E, c) and the S and K antigens by an elution technique comparing the AutoAnalyser and a manual method for the detection of eluted antibody are presented. Investigation of a series of anti-D sera demonstrates that while it is not too difficult to select antisera for the detection of the D antigen in fresh stains (i.e. up to 4 weeks old) some of these sera will not be satisfactory for typing older stains. The AutoAnalyser system used is low ionic strength/polybrene which has a capacity for detecting 0.002 microgram/ml of anti-D, but in spite of this degree of sensitivity the manual technique for the detection of eluted antibody compared very favourably and tended, where older stains were being tested, to give more conclusive results than the AutoAnalyser. The superiority of the manual technique was most pronounced when detecting the S and K antigens.

Autoanalysis↗