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Biomedical subjects

B E Boyes

Publications and source records attributed to B E Boyes.

33 records · Page 2Linked to original sources
PubMed1974

Asymptomatic liver disease in hepatitis B antigen carriers.

Thirty-four healthy blood donors, found to be persistent HBAg carriers, have been investigated by means of serial liver function tests, bromsulphthalein (BSP) retention, and liver biopsy. Thirty-one of the donors had histological abnormalities including one with cirrhosis, three with chronic aggressive hepatitis, and 11 with chronic persistent hepatitis. In 13 biopsies there were focal areas of necrosis in the liver parenchyma. Serial liver function tests revealed abnormalities in each of the donors with cirrhosis or with chronic aggressive hepatitis, in seven of the 11 donors with chronic persistent hepatitis, and in seven of the 13 with focal parenchymal necrosis. The degree of BSP retention was greatest (>11%) in the donors with chronic aggressive hepatitis. The severity of the histological changes was related neither to the titre of the antigen in the serum nor to the presence of autoantibodies.

Alanine Transaminase↗
PubMed1973

Zollinger-Ellison syndrome type 1: clinical and pathological correlations in a case.

Some patients with the Zollinger-Ellison syndrome appear to have hypergastrinaemia and hyperplasia of the antral G cells but no tumour. This subgroup has been classified as Zollinger-Ellison syndrome type 1. We have treated such a patient by vagotomy and antrectomy, the fasting plasma gastrin and acid secretion subsequently returning to normal.A 17-year-old male had a four-year history of duodenal ulcer. Gastric secretion tests showed acid hypersecretion. Fasting plasma gastrin was 8350 pg/ml (normal 50-170 pg/ml). At laparotomy duodenal ulceration was confirmed but no pancreatic or other tumours were found. Truncal vagotomy and antrectomy was performed with distal pancreatectomy. Immunofluorescent staining showed hyperplasia of G cells in the resected antrum but a normal pancreas and duodenum. Six months after operation he was symptom free and acid secretion was reduced by 92%. The fasting plasma gastrin at two months was <50 pg/ml. These findings suggest that type 1 Zollinger-Ellison syndrome may be a clinical entity.

Adolescent↗
PubMedDate not supplied

Rapid, high-resolution HPLC separation of peptides using small particles at elevated temperatures.

Practical advantages are described for operating small-particle columns at elevated temperatures to increase the peak capacity, resolution or speed for separating peptides. Columns of small, highly-purified porous silica microspheres with a dense covalently bonded, bulky alkylsilane stationary phase permit continuous operation at temperatures of at least 90 degrees C. Operation at elevated temperatures decreases mobile phase viscosity and enhances solute diffusion, resulting in increased column plate number and separation resolution. Higher temperatures also decrease column back pressure, permitting longer columns of small particles for separating complex mixtures requiring large plate numbers. Use of a sterically protecting di-isobutyl-n-octadecylsilane stationary phase ensures stable and reproducible columns for operation at high temperatures, with the aggressive low pH mobile phase preferred for separating peptides. The monomeric nature of this phase ensures rapid mass transfer and high column efficiency.

Chromatography, High Pressure Liquid↗