Electric activity of cat respiratory muscles during sleep.
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Biomedical subjects
Publications and source records attributed to B Duron.
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In 15 adult cats under nembutal anaesthesia the dorsal columns have been stimulated at the level of the first and the second cervical segments. Under these conditions antidromically evoked responses appear both on the ipsilateral radial and phrenic nerves. Some of the afferent phrenic fibres thus activated may be related to the diaphragm muscle receptors. In some experiments a group of thin fibres (conduction velocity comprised between 16-20 m/sec) were also activated.
In 20 Cats and 10 Rabbits, under Nembutal anaesthesia, the thoracic oesophagus has been distended at different levels by means of a small latex balloon. We have observed an inhibition of the electrical activity of the crura during the distensions of the lower oesophagus. This modification disappears after bivagotomy. Therefore it is probably mediated by a vagal reflex. The long duration of the observed inhibition suggests that the slow adaptating receptors lying at the level of the oesophago-gastric junction are involved.
During spontaneous breathing, the interchondral muscles present a pattern of activity similar to that of the diaphragm. The external intercostals and most of the internal intercostals generally show electrical discharges not related to ventilatory rhythm. Studies of the electrical responses of these muscles in experimental variations of their length show that the external and internal intercostals are readily activated by this category of reflexes while the diaphragm and the interchondrals are not. Bilateral multisegmental sections of spinal dorsal roots do not affect the respiratory activity of the diaphragm and of the interchondral muscles; on the contrary, all types of activity - spontaneous or reflex - disappear from the intercostals. Electrical stimulation of appropriate points in the bulbar pyramids in decerebrate cats can activate at the same time different intercostals and leg muscles without modifying the rhythmic inspiratory activity of the diaphragm and the interchondrals. In preparations with chronically implanted electrodes, the intercostals muscles are chiefly involved in posture. These results fit very well with our histological findings which disclose a much greater density of muscle spindles in external intercostals than in the diaphragm or in the interchondral muscles.
The electrical activity of intact branches of the phrenic nerve was studied during spontaneous respiration in the anaesthetized or decerebrate cat. The action potentials were displayed with opposite polarity according to whether their activity was of afferent or efferent origin. The afferent volleys could be grouped according to three modalities. The first group had a clear silent period during diaphragmatic contraction (72 percent). The second group had volleys during inspiration (25 percent). The third group (3 percent) had rhythmic bursts of fast potentials that were independent of the respiratory cycle.
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