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B Duquesnoy

Publications and source records attributed to B Duquesnoy.

191 records · Page 11Linked to original sources
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Causes of osteoporosis in males. A review of 160 cases.

BACKGROUND: The discovery of osteoporosis in a male requires a careful search for a cause. OBJECTIVE: To evaluate etiologic factors in male osteoporosis. PATIENTS AND METHODS: Males admitted to our department for osteoporosis were included if they had a nontrauma-related vertebral or peripheral fracture and/or a spinal or femoral neck bone mineral density value 2.5 standard deviations or more below the mean in young subjects. The study was retrospective from 1990 to 1995 and prospective from 1996 to 1997. During the prospective part of the study, each subject underwent a standardized battery of laboratory tests including renal tubular function parameters. Causes identified during these two periods were compared. RESULTS: Of the 160 patients included in the study, 28.1% had idiopathic osteoporosis, 22.5% had alcoholic osteoporosis, 19.4% had glucocorticoid-induced osteoporosis, 12.5% had osteoporosis due to moderate idiopathic proximal tubule dysfunction, and 8.8% had senile osteoporosis. The proportion of patients with idiopathic osteoporosis was 30% (23/76) during the retrospective part of the study and 26% (21/84) during the prospective part (nonsignificant difference). Moderate idiopathic proximal tubule dysfunction was found in 2.6% (2/76) and 21.4% (18/84) of patients during these two parts of the study, respectively, a difference ascribable to the routine determination of tubule function parameters during the second part of the study. CONCLUSION: An exhaustive search for a cause decreases the proportion of male osteoporosis cases that remain idiopathic. In our study, only 28% of cases were classified as idiopathic, a term that probably indicates involvement of multiple interrelated factors.

Adrenal Cortex Hormones↗
PubMedDate not supplied

[Radiographic study of the rheumatoid hand and etiopathogenic mechanisms of deformities. Apropos of 100 cases].

X-rays of the hands and wrists of 100 patients suffering from rheumatoid arthritis (RA) were compared to those of 65 control subjects matched for age and sex. Osteoarticular destruction was assessed using Larsen's index and by carpal bone deformities; ulnar deviation of the fingers (UDF) and radial deviation of carpal bones (RDC). No significant asymmetry of lesions in the right or left hands can be demonstrated, whatever the subsets of patients and osteoarticular manifestations studied. After a one year course, there is no significant difference between patients and control subjects. Only the index of carpal deformity is significantly high and the clinical course progresses between 1 and 5 years (p = 0.02). The difference becomes significant for UDF (p less than 0.01) after the disease evolves for 5 to 10 yrs. UDF is correlated with carpal osteoarticular lesions (p = 0.01) and metacarpophalangeal lesions (MCP). Different osteoarticular lesions of the hand are correlated with each other. The close correlation between UDF and RDC and MCP involvement has been confirmed by various statistical tests. Comparison of seropositive and seronegative patients with RA only reveals a more marked disturbance of MCP in the seropositive patients. Various methods of assessing osteoarticular deformities and joint destruction are discussed. Finally, the etiopathogenic mechanisms causing deformities of the hand in RA were studied, and the authors reviewed the importance of the initial involvement of soft tissues and therapeutic implications whereby prevention of disease extension using prompt local therapy is recommended.

Adult↗
PubMedDate not supplied

[Beta2 microglobulin, antibeta2 microglobulin activity and circulating immune complexes in rheumatoid arthritis. Serum and synovial study].

In this work, the authors found significantly raised serum Beta2m microglobulin values in a group of 120 cases of rheumatoid arthritis, without any difference between the serum positive group (55 cases) and the serum negative group (65 cases). Such a rise was found in the synovial fluids with a beta2 serum synovial fluid greater than unity in 81 % of cases of rheumatoid arthritis as against 6 % in a control group. The comparative study and the main immunological disorders permits one to note a correlation between the levels of circulating immune complexes (CIC) fixing the Clq and the serum beta2m in serum negative cases of rheumatoid arthritis (RA) (r = 0.52 p < 0.001) whereas this link does not exist in the serum positive group (r = 0.08). These conclusions led the authors to an anti-serum beta2m activity in the serum positive and negative groups of RA, which were very significantly different from the control groups. Furthermore, a study of complement activation, by titration of C3d showed a significant correlation between the levels of CIC and of C3d in RA -, but not in RA +. The authors discuss the participation of beta2m in the formatiton of CIC during RA and its role in the activation of complement.

Antigen-Antibody Complex↗
PubMedDate not supplied

Evaluation of bone mineral density in patients with rheumatoid arthritis. Influence of disease activity and glucocorticoid therapy.

OBJECTIVES: To study bone mass and the factors that influence bone mass in rheumatoid arthritis patients versus controls. PATIENTS AND METHODS: 85 patients (73 women) with a mean age of 57 +/- 11 years and a mean disease duration of 13 +/- 9 years were compared to 85 age- and sex-matched controls. Among the patients, 62 (76%) had positive rheumatoid factor tests and 51 (60%) were receiving steroid therapy, with a mean daily dose of 10 +/- 4 mg and a mean duration of 7 +/- 6 years. The following parameters were determined: morning stiffness duration, painful and swollen joint counts, Lee's and Ritchie's indices, Health Assessment Questionnaire score, erythrocyte sedimentation rate, and C-reactive protein. Bone mineral density was measured at the lumbar spine and femoral neck using dual-energy X-ray absorptiometry (Sophos L-XRA). RESULTS: In the nonsteroid-treated patients, bone mineral density was similar to that in controls at the lumbar spine but was decreased by 8% (95% confidence interval [CI], 1.8-14.2%) at the femoral neck (0.76 +/- 0.14 g/cm2 versus 0.83 +/- 0.15 g/cm2; P = 0.03). Decreases of 11.5% (95% CI, 8.1-14.9%) at the lumbar spine and 10.4% (95% CI, 6.4-14.4%) at the femoral neck were found in the steroid-treated patients versus the nonsteroid-treated patients. In the patient group, femoral neck bone mineral density was significantly negatively correlated with age (r = -0.5), the Heath Assessment Questionnaire score (r = -0.27), and the erythrocyte sedimentation rate (r = -0.25), whereas only the first two variables were significantly correlated with lumbar bone mineral density. A multiple linear regression model including age, glucocorticoid use, rheumatoid factor, the Health Assessment Questionnaire score, and the erythrocyte sedimentation rate was constructed and adjusted for the number of variables. This model explained 44.7% of the variance of femoral neck bone mineral density. CONCLUSION: Rheumatoid arthritis is associated with a decrease in bone mass that is most marked in patients with active and/or severe disease and in those who take glucocorticoids.

Absorptiometry, Photon↗