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Biomedical subjects

B Dupont

Publications and source records attributed to B Dupont.

At least 487 records · Page 27Linked to original sources
PubMed1977

Histocompatibility typing in spontaneous regression of retinoblastoma.

Human Leukocyte Antigen (HLA) Typing of Caucasian patients with retinoblastoma fails to show any difference in antigen frequency compared to a control population. In family studies where several members are affected with retinoblastoma the tumor does not segregate with the HLA type. There is also no significant difference in antigen frequency between spontaneous regression of retinoblastoma, unregressed retinoblastoma, and normal controls. In several families with one member showing spontaneous regression of retinoblastoma, other generations inheriting the same haplotypes have tumors which have failed to regress.

Eye Neoplasms↗
PubMed1976

Comparison of multiple in vivo and in vitro parameters in untreated patients with Hodgkin's disease.

Multiple in vivo and in vitro immune parameters were used to examine 52 untreated patients with Hodgkin's disease in all stages. A significant number (p less than 0.01) of patients in all stages demonstrated abnormalities in DNCB sensitization, peripheral blood lymphocyte response to phytohemagglutination, absolute lymphocyte count, absolute number of T cells (as measured by spontaneous rosette formation with sheep erythrocytes), and absolute number of B cells (as measured by immunofluorescence with polyvalent antiserum). The number of T and B cells fell progressively with each stage, but the proportion of T to B cells remained constant. Cutaneous anergy was found in STAGES III and IV. Depressed circulating immunoglobulins were found in a few patients in all stages. Neither the total lymphocyte number nor the number of T and B cells correlated with the measures of lymphocyte function (skin test reactivity, DNCB sensitization, mitogen response, or immunoglobulin levels). This study suggests that selective abnormalities in the immune system exist even in early Hodgkin's disease, involving the absolute number of circulating T and B lymphocytes and T-lymphocyte function. The study fails, however, to define a consistent pattern of immune defects as characteristic of Hodgkin's Disease.

B-Lymphocytes↗
PubMed1976

Immunogenetic aspects of allotransplantation.

It now appears unequivocal that three markers exist in a linkage group in chromosome 6 of man: HLA-A, HLA-B and PGM3 (Fig. 1.) Tentatively, two other HLA loci and one Ir gene have been mapped close to HLA-B. The probable map order is HLA-A - HLA-C - HLA-B - HLA-D - Ir. The biological functions of these loci are unknown. However, HLA-A, B and C are important in allograft rejection. Other closely linked loci (HDR, CML) appear to be important in the first events of the allograft rejection (first set) and in generation of killer cells. HLA-D might be important in cellular recognition and graft-versus-host reactions (matching at HLA-D decreases the incidence and severity of graft-versus-host disease), and the Ir genes in the defense against infections. HLA-B and HLA-D loci are important markers in studies of disease susceptibility. HLA-B locus antigens HLA-B27 and HLA-B8 are frequently associated with arthritic or autoimmune disorders. HLA-D determinants have been found in association with multiple sclerosis and C2 deficiency (HLA-DW2); juvenile diabetes and Addison's disease (HLA-DW3) and adult type of rheumatoid arthritis (HLA-DW4).

Alleles↗
PubMed1976

HLA antigen frequencies in paralytic dementia.

HLA typing was performed on 75 caucasian and 58 black patients with paralytic dementia hospitalized at 2 state mental institutions in New York. Serological testing was performed to confirm previous infection with T. pallidum. The caucasian patients showed an increase in B18(18.7% vs. 9.6% in controls). The black patients showed an increase in A2 (48.3% vs. 28.7% in controls) and an increase in B7 (27.6% vs. 15.7% in controls.

Black People↗
PubMed1976

Transfer factor treatment of patients with multuple sclerosis. I. Preliminary report of changes in immunological parameters.

In five patients with definite multiple sclerosis and lack of cell-mediated immunity to measles and parainfluenza virus antigens, various immunological parameters were studied before and during transfer factor treatment. The study showed that cell-mediated immunity to measles virus antigen, as evaluated by the leukocyte migration agarose test, could temporarily be restored, using repeated injections of transfer factor pooled from unselected, normal blood donors.

Antibody Formation↗