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Biomedical subjects

B Dube

Publications and source records attributed to B Dube.

At least 55 records · Page 3Linked to original sources
PubMed1981

Prothrombin-activator (thromboplastin) generation in the blood of water snake (Natrix piscator).

The generation of prothrombin-activator (thromboplastin) in water snake (Natrix piscator) is clearly delayed, compared to a mammalian system, but the final activity is well comparable to that in man, when homologous sources of "phospholipid" (erythrocyte-lysate) and of substrate plasma are employed in one stage "thromboplastin generation test". The use of heterologous source of either of the above reagents resulted in significantly longer clotting times; hence the need for homologous source of above reagents in the test is emphasized for comparative studies on animal haemostasis.

Animals↗
PubMed1981

Blood fibrinolytic system in rana tigrina.

Fibrinolytic activity as well demonstrable in the blood of Rana tigrina. There occurs prompt lysis of diluted plasma; and the plasma euglobulin fraction shows lysis on both unheated and heated fibrin (human or bovine) plates, implying the presence of plasmin-like enzyme in this fraction. The fibrinolytic activity is remarkably inhibited by the erythrocyte-lysate and is moderately enhanced by leucocytes-thrombocytes. EACA suppresses the lysis of dilute cell-free plasma clots at concentrations of 10(-4) M or more, possibly indicating the presence of plasminogen activator in the plasma. Activation of fibrinolysis by human urokinase and not by streptokinase, shows the probable presence of plasminogen and absence of proactivator.

Aminocaproic Acid↗
PubMed1980

Non-alcoholic cirrhosis of the liver in the tropics.

Amongst the chronic hepatic disorders in India, the cirrhosis of liver is common and its etiopathogenesis which is largly poorly understood, is a variance, to that of the West. During last two decades, several studies have been undertaken to study the small bowel status in hepatic disorders, particularly in the alcoholic cirrhosis). Similar studies on the tropical hepatic cirrhosis are few). It is likely that various intestinal infestation may be playing some role in its causation. The present study was designed to investigate the small bowel dysfunction in our cirrhotic patients and to find out the relationship, if any, with the electroencephalographic alterations.

Adult↗
PubMed1979

Fibrinolysis in the pigeon (Columba livia).

The presence of plasminogen activator in the euglobulin fraction of pigeon plasma, was demonstrated by conspicuous lysis on unheated fibrin plates; human as well as bovine fibrin were susceptible to lysis. The presence of free plasmin in euglobulin fraction was indicated by lysis on heated fibrin plates.

Animals↗
PubMed1979

Comparative studies of blood coagulation in hibernating and non-hibernating frogs (Rana tigrina).

1. During hibernation in frogs (Rana tigrina) there occurs prolongation of several clotting tests, viz, whole blood clotting time, plasma recalcification time, cephalin time and prothrombin time. 2. The ambient body temperature of the frog during winter hibernation is low and the retarded blood clotting at lower temperature may play an important protective role against intravascular thrombosis. 3. Shorter plasma recalcification time in low-spun plasma as compared to high-spun plasma indicated the presence of procoagulant activity in platelets/leucocytes of frogs.

Animals↗
PubMed1979

Muscle involvement in association with filarial chyluria.

Twenty unselected consecutive patients of filarial chyluria were evaluated clinically, electromyographically, and histopathologically for neuromuscular dysfunction. None of the patients showed clinical evidence of muscle wasting or weakness suggesting myopathy, although generalized muscle weakness was complained by all of them particularly while climbing the stairs or on getting up or during lifting heavy weights. Electromyographic abnormalities were found in nine patients and slight histopathological abnormalities in two. The average duration of motor unit potentials and the mean amplitude were reduced, compatible with myopathy. There were no fibrillation potentials. Histological abnormalities consisted of a marked variation in muscle fibre size, sarcolemmal nuclear proliferation, and mild interstitial fatty infiltration. None of the patients showed evidence of clinical neuropathy, abnormalities in conduction velocity along the nerves or signs of segmental demyelination in the biopsy of the nerve. Our data suggest that muscle weakness in these patients is myopathic in nature without peripheral nerve involvement, and is possible due to hypoproteinaemia and hypolipidaemia, as these patients lose excessive amounts of protein and fat in their urine.

Action Potentials↗
PubMed1979

Use of antifibrinolytic therapy in prostate surgery.

The prophylactic use of the antifibrinolytic drug, PAMBA, in a small intravenous dose preoperatively, combined with local irrigation postoperatively, effectively reduces blood loss. The drug is safe and relatively free of adverse side effects, but attentive postoperative care is warranted.

4-Aminobenzoic Acid↗
PubMed1979

Canine shock: irreversibility and coagulopathy.

Canine shock was experimentally induced by "superior mesenteric artery (SMA) occlusion followed by release:" two hours of occlusion produced reversible shock while four hours of occlusion caused irreversible shock. In both situations, the animals showed coagulopathy but the magnitude of same was more severe in animals with irreversible shock. The nature of coagulation changes was suggestive of intravascular coagulation. Histological changes showed widespread intravascular fibrin thrombi in the liver and the kidney in animals with irreversible shock and only limited local intravascular coagulation in the subcapsular region of the liver in those with reversible shock. The importance of diffuse intravascular coagulation in the irreversibility of shock was also corroborated by the "reversion" of shock by prior heparinization.

Animals↗
PubMed1978

Blood coagulation and fibrinolysis in haemorrhagic stroke.

Studies of 11 patients with haemorrhagic stroke revealed no significant change in kaolin cephalin clotting time, prothrombin time, thrombin time, PF 3 availability, platelet count and factor V and VIII during the first week. Plasma fibrinogen was significantly increased while factors VII + X were decreased (borderline significance). Prolongation of plasma recalcification time and decrease in heparin tolerance reached borderline significance. There was moderate, but significant, increase in serum antithrombin activity and plasma (euglobulin fraction) fibrinolytic activity.

Blood Coagulation↗
PubMed1978

Blood coagulation profile in patients with acute diffuse peritonitis.

Coagulation studies conducted on 42 patients with acute peritonitis of varying etiology revealed statistically significant prolongation of kaolin cephalin clotting time, decrease of platelets and elevation of plasma fibrinogen and serum fibrinogen degradation products. The relationship of the coagulopathy to bacterial invasion of peritoneal cavity was indicated by the absence of significant change in KCCT, prothrombin time, and bleeding time in patients with sterile peritoneal fluid. The results suggest a process of insidious defibrination intricately superimposed on the hypercoagulable state in these patients.

Acute Disease↗