Search PubMed⌕ Search

Biomedical subjects

B Drenger

Publications and source records attributed to B Drenger.

47 records · Page 3Linked to original sources
PubMed1987

Physostigmine and naloxone reverse the effect of intrathecal morphine on the canine urinary bladder.

Cystometrograms and urethral pressure profiles were used in 11 anaesthetized dogs to study the urodynamic effects of intravenously administered physostigmine (Group I--seven dogs) and intravenously administered naloxone (Group II--four dogs) following intrathecal morphine. In four of these dogs (Group III) intravenous physostigmine preceded the intrathecal morphine injection. In Groups I and II, intrathecal morphine 0.03 mg kg-1 caused a significant relaxation of the detrusor P less than 0.05), as expressed by a fall of 34.2 +/- 4.4% (SE) in mean intravesical pressure and a rise of 57 +/- 12.7% (SE) in calculated detrusor compliance at 90 min. Both physostigmine, 0.1 mg kg,-1 and naloxone, 0.025 mg kg,-1 given at this time completely abolished the influence of the narcotic on the bladder without changing urethral pressures. In Group III, physostigmine produced a marked rise in intravesical pressure (P less than 0.01) that was reversed by subsequent morphine. It is of interest that physostigmine, a potent cholinergic agent, and naloxone, a pure opiate antagonist, exert a similar action on bladder function.

Animals↗
PubMed1986

The action of intrathecal morphine and methadone on the lower urinary tract in the dog.

The effects of intrathecally administered morphine and methadone on lower urinary tract dynamics were investigated by cystometrograms and urethral pressure profiles in 16 anesthetized dogs. The examinations were performed before and 30, 60 and 90 minutes following intrathecal injection of 0.03 mg./kg. morphine or methadone. Intrathecal normal saline was used for control studies. Significant relaxation of the detrusor was noted after intrathecal morphine as expressed by a decrease in mean intravesical pressure (p less than 0.05) and by a rise in the calculated detrusor compliance. These effects were reversed by intravenously injected naloxone. As opposed to morphine, methadone caused an increase in detrusor tone. No appreciable effects were observed on the urethra after intrathecal morphine or methadone. Neither intravenous injection of the opiates nor intrathecal administration of saline caused alterations in bladder tone. The result may imply a spinal, albeit opposing, effect of the two opiates on bladder dynamics.

Animals↗
PubMed1986

Severe upper airway obstruction and difficult intubation in cicatricial pemphigoid.

Upper airway obstruction in cicatricial pemphigoid is rarely seen by the anaesthetist. A case of severe dyspnoea due to progressive laryngeal obstruction is presented. Tracheal intubation during induction of general anaesthesia for permanent tracheostomy was extremely difficult and was successfully performed by introducing a size 12 French suction catheter through the stenotic laryngeal orifice. Adequate ventilation was achieved by using the oxygen flush valve to deliver oxygen intermittently through the catheter.

Adult↗
PubMed1986

Erythroderma and pneumonitis induced by penicillin?

Penicillin and its derivatives are known to cause several dermatologic and pulmonary hypersensitivity reactions. This report describes a patient who presented with combined generalized exfoliative dermatitis and severe pneumonitis caused by penicillin and aggravated by ampicillin, methicillin and mezlocillin. Antibiotic challenges with penicillin caused immediate reappearance of the dermatological manifestation; reactivation of the pneumonitis was probably prevented by immediate discontinuation of the drug.

Adult↗
PubMedDate not supplied

Echocardiographic evaluation of the coronary sinus.

The purpose of this study was to compare transthoracic echocardiography (TTE) and transesophageal echocardiography (TEE) in the evaluation of the coronary sinus and its blood flow. Forty patients were studied by TTE and TEE. The distal coronary sinus and its right atrial communication could be identified in 21 of 40 by TTE, and in all patients by TEE. Coronary sinus diameter measurement at the right atrial communication was possible by TTE in 16 of 40, and in all patients by TEE (maximal diameter 6 to 14 mm, mean 9 +/- 2). Flow velocity measurement by pulsed Doppler was possible in 25 of 40 patients (63%) by TEE, and in none by TTE. The flow velocity pattern was similar to central vein flow velocity, with systolic and diastolic antegrade waves, and a small retrograde end diastolic wave. The coronary sinus cross-sectional area was measured in 5 patients by intravascular ultrasound. It varied in size and shape during the cardiac cycle, reaching a maximum (0.3 to 1.5 cm2) at end diastole, and decreasing by 40% to 70% at end systole. TEE is superior to TTE in the evaluation of the coronary sinus and its blood flow velocity. However, because of the variability in cross-sectional area size and shape, measurement of coronary sinus blood flow may be inaccurate.

Aged↗
PubMedDate not supplied

Intraocular pressure variation during strabismus surgery.

The changes in IOP during strabismus surgery were studied in 40 patients. In most, 37 eyes, there was a marked decrease of IOP during surgery and rapid return to initial levels of IOP. In 13 out of 14 eyes that underwent bilateral surgery, the IOP in the first operated eye returned to about baseline levels by the end of surgery on the second eye. No correlation was found between the changes in IOP and: the type of surgery, the operated muscles, the duration of surgery and anesthesia, or the patients' age. We surmise that the decrease of IOP is probably associated with the intensity of the massage of the globe during the surgery.

Adolescent↗