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Biomedical subjects

B Dhillon

Publications and source records attributed to B Dhillon.

At least 19 recordsLinked to original sources
PubMed2000

Rifabutin-induced uveitis with inflammatory vitreous infiltrate.

PURPOSE: To describe an ocular complication of rifabutin therapy in the treatment of Mycobacterium avium complex (MAC) infection in the absence of HIV infection or AIDS. METHODS: Three patients on rifabutin therapy for MAC chest infection developed anterior uveitis with vitreous infiltrates. The clinical course and visual outcome are discussed. RESULTS: The ocular signs of anterior segment inflammation along with vitreous infiltrate resolved on topical steroid therapy without long-term visual sequelae. CONCLUSION: This report highlights the potential of uveitis in patients treated for MAC infection with rifabutin without concurrent HIV infection or AIDS.

Aged↗
PubMed2000

Is cataract surgery justified in patients with age related macular degeneration? A visual function and quality of life assessment.

AIMS: To determine whether patients with age related macular degeneration (ARMD) benefit from cataract surgery in terms of visual function and quality of life measures, and to assess the impact of surgery on the progression of ARMD. METHODS: A prospective study was carried out of patients with and without ARMD undergoing cataract surgery. Data were collected from 187 patients at the Princess Alexandra Eye Pavilion, Edinburgh and the Oxford Eye Hospital, Oxford. The patients were divided into three groups: (1) a control group with ARMD and no surgery (n=41), (2) a study group of patients with ARMD who underwent cataract surgery (n=90), and (3) a second control group of patients without ocular comorbidities who underwent cataract surgery (n=56). Visual function and quality of life assessments were carried out at baseline and 3-5 months after baseline or surgery. RESULTS: There were significant improvements both in terms of quality of life and visual function measures in the study group. Benefits were greater in patients with moderate cataract irrespective of the degree of ARMD. No increased incidence in progression to the "wet" form of ARMD was found. Improvements in quality of life measures and visual function were more pronounced in patients with no ocular comorbidities. CONCLUSIONS: Patients with mild and moderate degrees of ARMD do benefit from cataract surgery and the benefits are greater in patients with moderate degrees of lens opacity. Longer follow up is required to assess the risk of increased ARMD progression.

Aged↗
PubMed1999

Intraocular metastases of cutaneous malignant melanoma: a case report and review of the literature.

Cutaneous malignant melanoma metastatic to the eye is rare but has been documented. The usual presentation is after the diagnosis of disseminated metastases. A 40-year-old Caucasian man presented with floaters and hazy vision due to ocular metastasis. He developed painful intractable rubeotic glaucoma leading to enucleation. Histopathological examination confirmed anterior segment tumour adherent to the iris that was consistent histopathologically with the primary cutaneous melanoma.

Adult↗
PubMed1998

Intravitreal sustained-release ganciclovir implantation to control cytomegalovirus retinitis in AIDS.

A novel form of therapy, the intravitreal ganciclovir implant (Vitrasert), was used to treat cytomegalovirus (CMV) retinitis in AIDS, when it was not possible to continue systemic therapy or disease progression was evident despite conventional intravenous treatment. A review of the ophthalmic and general health data, operative records and fundus photographs of 9 individuals who had Vitrasert implantation surgery in Edinburgh. Two patients received bilateral replacement implant procedures. Visual acuity, concomitant anti-CMV therapy, complications of implantation and control of retinitis were documented until final follow-up. Control of CMV retinitis was achieved in all individuals at one month postoperatively and remained controlled for a mean period of 5.8 months. Postoperative complications were mild and transient in all but 2 eyes of 2 patients who developed non-progressive macula oedema. Blinding complications as a result of surgery were not encountered and retinal detachment was not observed in this series. Vitrasert implantation is an acceptable and well tolerated treatment for CMV retinitis when systemic therapy fails to control disease progression.

AIDS-Related Opportunistic Infections↗
PubMed1998

Conjunctivitis.

Explore the source record for details and available documents.

Administration, Topical↗
PubMed1996

Squamous cell carcinoma of the eyelid and the acquired immunodeficiency syndrome.

PURPOSE: We studied a case of squamous cell carcinoma of the eyelid in a 42-year-old homosexual man with the acquired immunodeficiency syndrome (AIDS) to explore the link between squamous cell carcinoma and human Papillomavirus infection. METHOD: A rapidly growing, 3-mm lesion was removed from the right lower eyelid by excisional biopsy. RESULTS: Examination of the lesion confirmed squamous cell carcinoma. Polymerase chain reaction for human Papillomavirus 16 was positive. CONCLUSION: This case suggests a role for human Papillomavirus infection in the cause of squamous cell carcinoma in AIDS patients.

AIDS-Related Opportunistic Infections↗