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Biomedical subjects

B Devulder

Publications and source records attributed to B Devulder.

At least 163 records · Page 9Linked to original sources
PubMed1984

[Thyroid function in the nephrotic syndrome].

Serum Total Thyroxine (T4), Triiodothyronine (T3), Free Thyroxine (FT4), Free Triiodothyronine (FT3) Reverse Triiodothyronine and T3 Resin Uptake (T3RU) as well as basal and post stimulating TSH were measured in twenty clinically euthyroid patients with the nephrotic syndrome. In comparison with control values, our patients showed (1) significantly lowered mean serum TBG levels (p less than 0,05) (2) unmodified mean serum T3, FT3 and rT3 values (3) significantly lowered mean serum T4 and FT4 levels (p less than 0,001 and p = 0,027 respectively) (4) significantly higher mean basal TSH, and increased TSH response to TRH. We found a significant correlation between proteinemia and T4 or FT4 (p less than 0,001; p less than 0,01 respectively). In summary, our study: Shows that the low Total T4 observed in the Nephrotic Syndrome is not only due to a decreased protein bound T4, but also to a decreased FT4; And brings evidence for mild hypothyroidism in nephrotic patients.

Adult↗
PubMed1983

Lymphocytes T and pharmacokinetics after a single oral dose of levamisole in healthy and cancer subjects.

Levamisole, an anthelmintic drug with immunopotentiating activity, is shown to have variable effects on cell-mediated immunity. We have studied the effect of a single oral dose (2.5 mg/kg or 5 mg/kg) on early and spontaneous E rosettes percentages in healthy and cancer patients. Pharmacokinetic study of this compound was conducted in parallel. The results indicated that single administration of levamisole (2.5 mg/kg) in healthy men can promote an increase of early E rosettes with mean peak plasma level of 0.8 micrograms. ml-1. On the other hand, there was no change in the proportion of early E rosettes in cancer patients and in the proportion of spontaneous E rosettes in healthy and cancer subjects.

Humans↗
PubMed1982

[Surgical treatment of Prinzmetal variant angina. Coronary artery by pass and plexectomy (author's transl)].

Aorto-coronary by pass, widely accepted in the treatment of patients with coronary artery disease is still controversial in the treatment of Prinzmetal variant angina. Recurrence of attacks, occlusion of grafts and post-operative infarction were frequent by described and seem to be related with the persistence of coronary spasm. Authors propose the association of myocardial revascularization and coronary denervation by resection of periaortic plexi. Results of 50 surgical plexectomies associated with coronary by pass appear far better than by pass alone (mortality 4%, myocardial necrosis 4%, persistence of attacks 4%).

Adult↗
PubMed1979

[Repeated abortions, sterility and systemic dysimmunopathy (author's transl)].

A patient with lupus disease had a previous medical history of five recurrent temporary bouts of thrombopenia which were followed by spontaneous abortions. This raises the two-fold problem of the relationship between circulating immune complexes disease and thrombopenia, and dysimmunopathy and pregnancy disorders. The hypothesis is raised of a trophoblastic necrotizing angeitis due to abnormal immunity processes involved in some cases of sterility, spontaneous abortions, and even nephropathies during pregnancy.

Abortion, Habitual↗
PubMed1979

[Paravertebral hematopoietic pseudotumor during Paget's disease (author's transl)].

Extramedullary hematopoiesis is usually secondary to a severe and prolonged reduction in medullary functions, but can be the rare consequence of an extrusion of tissue formed of weakened or fractured bone. The hematopoietic nature of this pseudotumor can be confirmed histologically or, as in this case of Paget's disease, by Indium scintigraphy which can define the specific locations of the hematopoietic marrow.

Aged↗
PubMed1979

[Systemic allergic vasculopathy after naproxen (author's transl)].

The authors report a case of hypersensitivity angiitis presenting with cutaneous, muscular, articular, and renal signs. They suggest a possible etiological mechanism for such disorders: a circulating immune-complex disease, and criticize the often improper interpretation of the results of lymphoblast transformation tests. Hypersensitivity angiitis, "ground base disease", requires investigation for possible underlying immunity abnormalities or neoplasms.

Aged↗
PubMed1978

[Direct examination in immunofluorescence of temporal artery sections. Value and limitations (author's transl)].

Although invariably seen with immunofluorescence in Giant Cell Temporal Arteritis, deposits of immunoglobulins and complement in the wall of the temporal arteries is nevertheless not specific to his condition. The results of the preliminary study reported here would seem to indicate that this phenomenon is related to the dysimmune state. A simple investigation, temporal artery biopsy with examination in immunofluorescence may be used to provide evidence for a diagnosis of circulating immune complex disease, the type of which can be defined only by the clinicopathological and biological context. Thus the practical value of temporal artery biopsy goes far beyong giant cell arteritis only.

Complement System Proteins↗