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Biomedical subjects

B Delcambre

Publications and source records attributed to B Delcambre.

At least 91 records · Page 5Linked to original sources
PubMed1990

Septic Streptococcus milleri spondylodiscitis.

We describe 2 patients presenting lumbar spondylitis due to Streptococcus milleri. In both cases origin was related to preexistent intestinal pathology. Surgical drainage of a collection of pus was necessary in one case. Longterm antibiotic therapy led to full recovery. Despite confused nomenclature Streptococcus milleri must be considered a serious pathogen mainly associated with purulent infection with osteoarticular affinity.

Abscess↗
PubMed1989

[Functional consequences and complications of Paget's disease].

Paget's disease is a common bone disease which usually has little influence on the patient's mobility. Functional symptoms, such as pain, and bone deformation can be controlled partly by treatment. Cardiovascular complications are rare, except for arterial hypertension which seems to be closely related to the skeletal dystrophy. The incidence of sarcoma is difficult to evaluate, but that disease has a frightful prognosis little improved by therapeutics. Neurological manifestations are diverse and due to anatomical alterations and vascular steal syndromes. Bone fractures are frequent and sometimes herald the disease. Pagetic arthropathies may benefit from surgery after medical treatment.

Aged↗
PubMed1989

Osteomesopyknosis. Report of two new cases.

Two inherited cases of osteomesopyknosis are reported. This is an autosomal dominant osteosclerosis described by Maroteaux in 1980; its radiological abnormalities consist of increased density of the vertebral plates, pelvis, and sometimes of the upper part of the femur. Osteomesopyknosis, usually discovered incidentally on radiographic examination, is a mild form of familial osteosclerosis and must be distinguished from osteopetrosis which carries a worse prognosis.

Adolescent↗
PubMed1989

Cholestasis and pneumonitis induced by gold therapy.

The authors describe the association of gold salt-induced cholestasis and lymphocytic alveolitis proved by liver biopsy and broncho-alveolar lavage. To our knowledge this is the third case report on the combination of liver disease and pulmonary infiltration induced by gold compounds.

Aged↗
PubMed1989

Subclinical alveolar inflammation in rheumatoid arthritis: superoxide anion, neutrophil chemotactic activity and fibronectin generation by alveolar macrophages.

Interstitial lung disease (ILD) can be detected by pulmonary function testing (PFT) in 30-40% of rheumatoid arthritis (RA) patients. We assessed by bronchoalveolar lavage (BAL) the patterns of alveolitis in 21 RA patients: group 1 comprised 12 patients without evidence of ILD, and group 29 patients with clinical ILD defined by abnormal pulmonary function tests and/or chest X-ray. Cellular characteristics of BAL were studied in both groups. In addition, alveolar macrophages (AM) from patients in group 1 were isolated, and three parameters of cellular activation were studied: superoxide anion, fibronectin and neutrophil chemotactic activity generation. Total cell counts were not increased in group 1 but significantly increased in group 2 compared to controls. In group 1, 5/12 patients had elevated lymphocyte percentage (greater than 18%) suggesting subclinical lymphocyte alveolitis. In contrast, neutrophil alveolitis (greater than 4%) was found in 7/9 patients in group 2, mean percentage 12.9 +/- 4.2, compared with 1.2 +/- 6.4% in controls and 1.9 +/- 0.5% in group 1. These changes were not correlated with disease duration nor rheumatoid factor titres. Marked elevation of lymphocyte percentage was observed in patients with abnormal serum beta-2-microglobulin. Alveolar macrophages from group 1 patients released increased amounts of superoxide anion (7260 +/- 2700 vs controls 850 +/- 120 URL/5.10(5) cells), neutrophil chemotactic activity (21 +/- 4.8 vs controls 8.1 +/- 0.7 cells/HPF), and fibronectin (6.1 +/- 1.6 vs controls 1.3 +/- 0.2 ng.10(6) cells/hour). Whether or not lymphocyte alveolitis and/or AM dysfunction are pathogenic mechanisms of subsequent interstitial lung disease in patients who are still free of symptoms remains to be determined.

Adult↗
PubMed1988

[Serum, synovial and intra-articular pharmacokinetics of naproxen after one-gram oral administration in patients with rheumatoid polyarthritis].

After a reminder of the major points of the pharmacokinetics of non-steroid anti-inflammatory drugs, the authors report the results of a multicentric study of the kinetics of naproxen after oral intake of one single dose of 1 gram in patients with rheumatoid arthritis. The half-life is longer in the synovial fluid than in the serum, 23 hours versus 17 hours. The balance point is obtained at the 24th hour and, at that time, the naproxen level in the synovium and the joint fluid are 32 and 60 p. cent, respectively, of the corresponding maximum concentrations.

Administration, Oral↗
PubMed1988

[Movements of the lumbar spine. A biomechanical study].

The lumbar spine presents movements of flexion-extension, lateral inflexions and rotations, which are, in fact, the result of movements within each mobile spinal segment. These mobile segments present six levels of freedom corresponding to translation and rotation movements in the three spacial planes. Lumbar mobility decreases markedly with age. Muscles not only participate in the movement itself, but also in its control and in maintaining spinal stability. Their action also depends on the effect of gravity. The authors report various studies concerning spinal stresses during varied movements and positions. Flexion of the trunk is the most stressing; walking, rotations and lateral inflexions increase only moderately the intradiscal pressure. All of the these results concur with the classic ergonomic notions.

Abdomen↗
PubMed1988

Dialysis-related beta 2 microglobulin-amyloid arthropathy. Improvement of clinical symptoms after a switch of dialysis membranes.

Amyloidosis containing beta 2 microglobulin (beta 2m) and joint pains are frequent complications of long-term hemodialysis. In a prospective study the authors planned to act on dialysis arthropathies (DA) by improving beta 2m depuration: for 8 patients suffering from DA we replaced usual cuprophane membranes (CU) by high permeability polyacrylonitrile membranes (PAN). DA was diagnosed on the presence of severe disabling arthralgias in the absence of any other obvious etiology, and on the presence of at least 3 among 6 criteria. The efficacy of the switch of DM was assessed on 6 criteria including the patient's own evaluation at the end of the study and a joint pain severity index. Clinical evaluation and beta 2m measurement were carried out at the start of the trial and after a mean duration of dialysis on PAN of 6 months. An improvement in joint symptomatology and a decrease of joint severity index were noted in the 8 cases. Our results suggest that the change of DM has a favorable influence on DA. This improvement could result either from a better beta 2m depuration or from a better biocompatibility of PAN than the CU previously used.

Amyloidosis↗
PubMed1988

[Osteoarthropathy of hemodialysis: development at 2 years after passage on high permeability membrane].

In a group of 80 patients dialyzed at the same dialysis center, dialysis arthropathy was diagnosed in ten of them. Before commencing the study all ten patients were undergoing hemodialysis with cuprophan membrane (CU). We then replaced CU with high permeability membrane (polyacrylonitrile AN 69 Hospal or polysulfone) in eight of these ten patients. Clinical and radiological evaluation as well as bêta 2 microglobulin measurement were performed at the onset of the study and at one year and two years intervals after replacing the dialysis membrane. An improvement of joint symptomatology was noted in all patients. However, the radiological abnormalities appeared unchanged or aggravated and the mean serum concentration of bêta 2 microglobulin was lower at the end of the study but not significantly.

Adult↗