Biomedical subjects

B De Man

Publications and source records attributed to B De Man.

3 recordsLinked to original sources

PubMed2001

An iterative maximum-likelihood polychromatic algorithm for CT.

A new iterative maximum-likelihood reconstruction algorithm for X-ray computed tomography is presented. The algorithm prevents beam hardening artifacts by incorporating a polychromatic acquisition model. The continuous spectrum of the X-ray tube is modeled as a number of discrete energies. The energy dependence of the attenuation is taken into account by decomposing the linear attenuation coefficient into a photoelectric component and a Compton scatter component. The relative weight of these components is constrained based on prior material assumptions. Excellent results are obtained for simulations and for phantom measurements. Beam-hardening artifacts are effectively eliminated. The relation with existing algorithms is discussed. The results confirm that improving the acquisition model assumed by the reconstruction algorithm results in reduced artifacts. Preliminary results indicate that metal artifact reduction is a very promising application for this new algorithm.

Algorithms↗

PubMed2000

Are changes in myocardial integrated backscatter restricted to the ischemic zone in acute induced ischemia? An in vivo animal study.

Integrated backscatter (IB) from a myocardial region, calculated from radiofrequency echocardiographic data, has been proposed as a useful parameter for investigating changes in myocardial tissue induced by ischemia. In 10 closed-chest dogs, 5 minutes of myocardial ischemia was induced by either a proximal occlusion of the circumflex coronary artery (CX) (5 dogs), resulting in extensive ischemia in the posterior wall, or by occluding the distal CX vessel (5 dogs) to produce a small localized ischemic zone in the posterior wall. High-resolution digital radiofrequency data from the whole left ventricular myocardium, in the imaging plane during one complete heart cycle, were acquired with a whole-image real-time acquisition approach. Regions in the septum and posterior wall (both ischemic tissue and, in the case of distal occlusions, tissue surrounding the ischemic zone) were chosen for analysis, and IB and cyclic variation (CV) of IB were calculated. Post occlusion, an increase in mean IB values was found in the ischemic segment. However, an increase in CV was also observed in the peri-ischemic zone for the distal CX occlusion and in the septum after proximal CX occlusion. These findings show that changes in CV are not restricted to the ischemic zone but may also occur in distal myocardium. This may be explained by changes in the regional contractile state and loading conditions of the "normal" myocardium, which are altered in response to the distal ischemia.

Animals↗

PubMed1998

Iterative reconstruction for helical CT: a simulation study.

Iterative reconstruction algorithms for helical CT are presented. The algorithms are derived from two-dimensional reconstruction algorithms, by adapting the projector/backprojector to the helical orbit of the source, and by constraining the axial frequencies with a Gaussian sieve. Simulations have been carried out and the performance of the iterative algorithms is compared to that of filtered backprojection of synthetic (interpolated) two-dimensional sinograms. The iterative algorithms produce superior bias-noise curves. Axial resolution is superior, but disturbing edge-artefacts are introduced.

Algorithms↗