[Correlations between serum neuraminic acid level and encephalographic results in cerebro-cranial trauma].
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Biomedical subjects
Publications and source records attributed to B Darwaj.
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By polygraphic methods the authors studied the sleep patterns during treatment of patients with subtentorial tumours causing hydrocephalus. Sleep recording was carried out in three stages of treatment: 1) before insertion of ventriculo-atrial valve, (7 investigations), 2) on the 7th day after valve insertion (7 investigations), 3) two months after removal of the posterior fossa tumour (3 investigations). The control group included patients with peripheral nerve injury in whom sleep recording was done before and after surgical treatment. In cases with hydrocephalus and raised CSF pressure before valve insertion the cyclic pattern of sleep was disintegrated, showing long periods of light sleep (phase 1 + 2) interrupted by long periods of alertness, during sleep, mostly with elimination of the remaining sleep components. The decrease of CSF pressure after valve implantation was parallelled by partial normalization of sleep pattern, that is shortening of the light sleep phase and reduction of the number of alertness during sleeping hours, as well as prolongation of the phases of deep sleep and appearance of paradoxical sleep. However, only removal of the tumour from the posterior fossa made possible approximation of sleep elements to those in the control group. Sleep disintegration of varying intensity in patients with hydrocephalus may be reversible, the rate of normalization of sleep depends on the intensity of sleep disturbances in the initial stage of the disease, but return to nearly normal sleep is possible only after removal of the subtentorial tumour.
In 6 patients treated for hydrocephalus caused by posterior fossa tumours simultaneous continuous measurement of intraventricular cerebrospinal fluid pressure and all-night polygraphic sleep recording were carried out before and after implantation of ventriculoatrial valve. It was observed that in patients with hydrocephalus and raised CSF pressure electrography demonstrated a breakdown of the cyclic sleep pattern with increased duration of light sleep and higher number of awakening episodes, and with reduced amount of deep sleep and nearly complete absence of REM sleep. The degree of sleep disturbances seemed to be correlated with increased value of CSF pressure. In that period discrepancies were observed between the sleep record suggesting waking and the behaviour of the patient who was asleep at that time. With normalization of CSF pressure record (after valve implantation) an improvement of sleep pattern was observed which approached the normal one.
Thirty-seven patients with vertebrobasilar arterial insufficiency were divided into two groups depending on their clinical condition. In the group of patients with more severe clinical manifestations the intensity of EEG changes was correspondingly greater. In this group in 7 patients the EEG background activity was disturbed, in 4 of them focal changes were present in the left temporal area. Of the patients with less severe clinical changes the background activity was disturbed in 1 cases only.