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Biomedical subjects

B D Wilson

Publications and source records attributed to B D Wilson.

At least 73 records · Page 4Linked to original sources
PubMed1982

Experimental murine hypersensitivity pneumonitis: multigenic control and influence by genes within the I-B subregion of the H-2 complex.

An animal model of hypersensitivity pneumonitis was developed in the mouse by immunization with pigeon dropping extract (PDE) in complete Freund's adjuvant, followed by daily aerosol challenge with soluble specific antigen. C3H/He (H-2k) mice developed intense diffuse interstitial lung disease and were classified as high responders. On the other hand C57BL/10 (H-2b) mice developed only mild perivascular infiltration. Moreover, although high-responder C3H/He mice developed delayed hypersensitivity to PDE, low-responder C57BL/10 mice failed to develop this reactivity. Breeding studies in F1 and F2 progeny of C3H/He high responders and C57BL/10 low responders showed that responsiveness was multigenic. B10.BR (H-2k) mice also developed intense PDE-induced diffuse interstitial lung disease, suggesting that genes within the H-2 complex influence the development of pulmonary inflammation. On the other hand, C3H.SW (H-2b) mice were also high responders, possibly because of non-H-2 genes in the C3H/He background that influenced responsiveness. Studies in H-2 recombinant strains with C57BL/10 backgrounds mapped the H-2-linked genes that influence responsiveness within the I-B subregion.

Alveolitis, Extrinsic Allergic↗
PubMed1980

Epidermolysis bullosa acquisita: a clinical disorder of varied etiologies. Two cases and a review of immunologic and other reported findings.

Epidermolysis bullosa acquisita (EBA) is an acquired mechanobullous disorder characterized by traumatically induced bullae in skin subjected to frictional injury, i.e., acral extensor surfaces or any point of sufficient mechanical distress. Two new patients with EBA are reported. Histopathologic findings were subepidermal ballae with sparse superficial perivascular mononuclear cell inflammatory infiltrates. The periodic acid-Schiff (PAS)-positive basement membrane zone (BMZ) was split between the floor and roof of the blisters with most attached to the blister roof. Electron microscopy of normal skin from one patient revealed a bandlike zone of granular material within the dermis immediately beneath the basal lamina. Nonbranching filaments were embedded in the granular material. Electron microscopy of normal skin from the second patient revealed a markedly diminished density of anchoring fibrils but no granular material. Immunologic findings in skin biopsies were C'3, IgG, and other immunoglobulins in varying combinations in both cases and in all reported cases. Comparisons of direct immunofluorescent (IF) findings in nine reported cases with 223 cases of bullous pemphigoid (BP) suggest that BMZ deposits of IgG plus IgA and/or IgM occur more frequently in EBA than in BP. Indirect IF studies of patients' sera revealed antibodies to the BMZ in two samples of one of our two cases and in one of seven cases reported by others. While both EBA and BP characteristically yield positive IF findings in the BMZ, clinical, electron microscopic, and some immunopathologic findings indicate that the two diseases are distinct.

Adult↗
PubMed1979

Forces exerted during exercises on the uneven bars.

The purposes of this study were (1) to develop a technique to measure the force exerted on uneven bars during a gymnast's performance, and (2) to determine the magnitudes of the maximum forces exerted on the bars during normal use. Strain gages, a UV recorder, and motion-picture cameras were used to record the forces exerted against the bars and the motions with which they were associated. Three college gymnasts were used as subjects. Each performed several repetitions of an exercise sequence judged to result in the maximum loading of the bars she might produce under normal conditions. The maximum forces recorded were 3500 N (low bar) and 2140 N (high bar). These values were recorded during a sharp impact between the subject's thighs and the bar during the passage of the subject beneath the bar in a giant swing, respectively. Making due allowance for possible measurement error and for the estimated effects of the bars being used by gymnasts of greater mass than those in this study, it was concluded that bars should be designed to withstand repeated loads of at least 4205 N.

Adult↗
PubMed1977

A follow-up of admissions to the California Civil Addict Program.

A follow-up interview study of early admissions to the California Civil Addict Program found that those continuing in the program performed substantially better during the commitment period than did a comparable group discharged shortly after admission. To a lesser extent, the program also appeared to have had some impact subsequent to discharge. Those program discharges defined as successes tended to do relatively well until the time of interview. Comparisons under the strict (pre-1970) and more lenient regimens showed roughly comparable behavior, but the availability of methadone maintenance was also a significant factor in reducing heroin use during the latter period.

Adult↗
PubMed1975

Thermal responses to intermittent work in selected enironments.

Acclaimed subjects exercised intermittently for 8 hrs in 25 to 50 degrees environments. Thermal and metalobic determinations were made. Results showed the time-weighted WBGT heat strain index for intermittent work needs re-evaluation. For acclimated subjects working steadily at 350 kcal/hr, 30% max, the ULPZ is more than 33% WBGT.

Acclimatization↗