Search PubMed⌕ Search

Biomedical subjects

B D Silverman

Publications and source records attributed to B D Silverman.

27 records · Page 2Linked to original sources
PubMed1982

Tricuspid regurgitation and acute myocardial infarction.

A 71-year-old man had a right ventricular infarct complicated with hypotension and transient complete atrioventricular block. The patient was found to have tricuspid regurgitation, which was corrected with a prosthetic tricuspid valve. After correction, there was dramatic improvement in his clinical status, with correction of persistent hypotension and weakness and early discharge home to full activity. Tricuspid regurgitation is a mechanical defect of acute myocardial infarction that benefits greatly from surgical correction. This therapy should be considered in any individual in whom tricuspid regurgitation complicates acute right ventricular infarction.

Acute Disease↗
PubMed1982

Steric crowding and conformer stability of the diol-epoxides of benzo(c)phenanthrene.

The relative stabilities of conformers of the syn and anti-diastereomers of the fjord and bay-region diol-epoxides of benzo(c)phenanthrene (BCP) and benzo(a)anthracene (BA) have been calculated. Steric crowding in the fjord-region of BCP is shown to stabilize the syn-diequatorial and anti-diaxial conformers of BCP. In contrast, the most stable conformers of the bay-epoxides of BA are found to be the syn-diaxial and anti-diequatorial.

Epoxy Compounds↗
PubMed1982

Carcinogenicity of methylated hydrocarbons: effect of methylation on the calculated diol-epoxide reactivity.

Methyl substitution of polycyclic aromatic hydrocarbons is known to induce substantial variations in carcinogenicity. The "Bay-region" theory relates carcinogenicity of polycyclic aromatic hydrocarbons to ease of formation of a triol carbocation from a bay-region diol-epoxide. It is shown that an examination of certain simple consequences of molecular orbital theory enables one to identify certain methyl substitutions that do not enhance ease of carbocation formation and hence are the least carcinogenically activating.

Benz(a)Anthracenes↗
PubMedDate not supplied

Three-dimensional moments of molecular property fields.

Descriptors that capture certain three-dimensional molecular features and do not require molecular superposition or alignment for the assignment of molecular similarity have recently been proposed and investigated. Among these, moments of molecular features have been utilized in the QSAR of several molecular series. The present work examines certain formal aspects of the use of moment expansions for which the zero-order moment of a property field is nonvanishing. The first-order term of such moment expansion is then dependent upon the origin of expansion, and it is pointed out that expansion about the molecular centroid is descriptive of first-order differences about the property-field mean. For a hydrophobic property field, this first-order term is just the Eisenberg hydrophobic moment. Second-order moments about the centroid can be written as components of the WHIM covariant matrix. Moment expansions are also performed about the property-field center in analogy with expansions about the center of mass. For such expansion, a set of descriptors consisting of moments of the molecular density and of a molecular hydrophobic property field as well as of related quantities are used in a QSAR of the binding of 74 polyhalogenated aromatic molecules to the Ah cystolic receptor. This QSAR has been named CoMMA2 to distinguish it from CoMMA, for which the zero-order moment of the expansion vanishes.

Journal Article↗