Search PubMed⌕ Search

Biomedical subjects

B D Katthagen

Publications and source records attributed to B D Katthagen.

At least 19 recordsLinked to original sources
PubMed2000

Erdheim Chester disease: a rare cause of knee and leg pain.

A case of Erdheim Chester disease in a 51-year-old Turkish patient is described. Erdheim Chester disease is a rare form of lipoid granulomatosis. Knee and leg pain are the most common symptoms, and physicians working in orthopaedics and traumatology are the first to be consulted. Our patient demonstrated a typical bilateral, symmetric sclerosis of the metaphyseal region of long bones of the lower extremity, histologic examination revealed foamy, lipid-loaded histiocytes. The patient also suffered from arterial hypertension, diabetes insipidus and exophthalmos of the left eye. The diagnosis was confirmed by a bone biopsy, and the patient was treated with non-steroidal anti-inflammatory drugs, corticosteroids and vincristine.

Granuloma↗
PubMed2000

[Femoral torsional deformities].

First, we describe the physiological development of the torsion of the femoral neck, starting from about an angle of 35 degrees at the time of birth up to an angle of a mean value of about 15 degrees at the end of bone growth. Furthermore, we explain diagnostic procedures (clinical examination, X-ray, tomography) according to their clinical relevance. The differences from the normal range are discussed in their pathogenetic context with the clinical symptoms characteristic for the hip and knee joint. The most relevant aspect of the pathological torsion of the femoral neck is a decreased antetorsion angle, while an increased antetorsion angle was overestimated in the past.

Adolescent↗
PubMed1999

Weight-based heparin dosing is more effective in the treatment of postoperative deep vein thrombosis.

Rapid clinical diagnosis and adequate treatment are the major determinants of successful therapy of deep vein thrombosis (DVT). In the initial treatment of DVT, heparin is the anticoagulant of choice. Appropriate heparin dosing is of major interest concerning the onset of therapeutic anticoagulation and, thus, the clinical outcome of the patients. This study was designed to compare a weight-based heparin nomogram with a standard heparin nomogram for the treatment of DVT in orthopaedic patients. Forty patients in two groups were included in the study. In group one (patients treated with the weight-based heparin nomogram) the therapeutic range (partial thromboplastin time 1.5-2.3 times the control) was reached on average within 24 h (75% of the patients); 95% of the patients reached the therapeutic range within 48 h. In group two (patients treated with the standard heparin nomogram) the therapeutic range was reached on average within 48 h (60%; 30% of the patients reached the therapeutic range within 24 h). The used weight-based heparin nomogram has proved to be effective, safe and superior to one based on standard practice concerning the time elapsed between initial heparin therapy and achieving the therapeutic range for intravenous anticoagulation.

Aged↗
PubMed1997

[Acetabuloplasty].

Lateral acetabular osteotomy in comparison to three-dimensional osteotomies of the pelvis in hip dysplasia is a simple technical procedure. Contraindications are an age over 8 years and an irreducible femoral head. For a long time we have used xenogenic deproteinized bone wedges from animals. We now use autoclaved and deep-frozen wedges from allogenic femoral heads. The wedges are sterilized at 121 degrees C for 20 min and then kept deep-frozen in the bone bank. Our results in 109 patients show that this method is very successful; even extreme angles of acetabular index correction are possible with this technique. It is unfortunate that the lateral acetabuloplasty with autoclaved allogenic bone graft is not used frequently and we recommend that this method be installed at all paediatric orthopaedic hospitals.

Acetabulum↗
PubMed1993

[3D-CT and angiography of cast preparations of pelvic vessels: demonstration of arterial blood supply of the acetabulum].

Anatomical studies of the arterial blood supply of the acetabulum were performed utilizing conventional angiography and 3D-CT on 27 hip specimens. In 16 cases the arterial arborization was filled with undiluted barium-sulfate via the internal artery and in 11 cases with a solution of resin and lead power. 3 specimens out of 30 were excluded because of extravasation using barium-sulfate in one case and incomplete filling with resin in 3 cases. Conventional angiograms were performed in all specimens and in preparations with resin/lead power additional three-dimensional reconstructions of the surface of the acetabulum and arterial cast were done with 3D-CT. 3D-CT shows precise relationship of the arteries to the acetabulum in any spatial plane and definition of vascular supply without elaborate preparation. 3D-CT is superior to non-selective conventional angiography because of better definition of arterial arborization. Filling with resin and lead powder is optimal for anatomical studies because of its reliability and stability. It permits comparative 3D-CT and conventional x-ray examination and subsequent preparation of the vessels in corrosion technique. The advantages of 3D-CT in vessels of cadaver specimens should encourage research on its viability in patients.

Acetabulum↗
PubMed1988

Effects of human alpha-interferon on granulocyte-macrophage progenitor cells (CFU-GM) in vitro.

Two preparations of human interferon (IFN)-alpha were assessed for their influence on granulocyte-macrophage progenitor cells (CFU-GM) in vitro. Both highly purified human IFN-alpha Ly and recombinant IFN-alpha 2a suppressed CFU-GM colony formation in a dose-dependent manner using low-density bone-marrow target cells. Suppression of CFU-GM colony formation was accompanied by an increase in clusters. However, depletion of monocytes, T lymphocytes and B lymphocytes from low-density bone-marrow cells resulted in insensitivity of progenitor cells to IFN-alpha. These results demonstrate that the effects of human IFN-alpha on myeloid progenitor cells (CFU-GM) are mediated by accessory cells within the bone marrow.

Cell Division↗
PubMed1985

[Operative long-term results in delayed radius head dislocation in childhood].

Only some cases and no long term follow-ups are reported in literature concerning the problem of delayed luxations of the radial head in children. 21 cases (19 acquired and 2 inherited) were treated in our hospital by operative procedure 12.5 months after the accident on the average. Disregarding one early and one late resection of the radial head we reconstructed the joint reposition and annular ligament plasty and if necessary correction osteotomy of the ulnar or shortening of the radius. Follow-up examination took place between 2 and 16 years after the operation, 7.9 years on the average. A reluxation was observed in 2 cases, a subluxation in 1 case. 2 patients showed a wrong axis and 4 patients signs of a beginning radio-humeral arthrosis, but most results were good or satisfactory. Therefore a reconstruction of a luxation of the radial head in children is recommended in delayed cases (sometimes in combination with a correction osteotomy of the ulna or radius) in contrast to other authors.

Adolescent↗
PubMed1984

Experimental animal investigation of bone regeneration with collagen-apatite.

Multicentric osteoregeneration is a new principle of osteoinduction [31a] which can be realized with the combination of collagen and fine dispersed hydroxyapatite ceramic particles (Collapat). This was histomorphometrically proved in the present study involving 14 rabbits with 28 6-mm-wide bore holes in the distal femoral condyles. With Collapat, an average of 5 times more new bone was regenerated than in the control defects without implant. The Wilcoxon matched-pairs signed-ranks test proved the positive effect of the implant Collapat on osteoregeneration with a significance of P less than 0.0001. At sites of Collapat insertion bone regeneration begins in the 2nd week, reaches its climax in the 3rd week, and is completed after the 4th week. in the course of development the histological picture is typified by a lively bone remodeling. Bone formation can be recognized in direct contact to the apatite granules. Foreign body or allergic reactions are not observed. Remodeling of the bone is not hindered by the slowly resorbable apatite granules. About 250 human implantations have been performed in our hospital since 1979, with good results and no negative effects.

Animals↗
PubMed1981

[Fractures of the spine - long-term results of functional treatment (author's transl)].

644 fractures of the spine without paraplegia treated at the "Bergmannsheil" Hospital in Bochum between 1963 and 1977 are reported. Indications and long-term results of functional treatment are discussed. More than 80 per cent of the anterior wedge fractures had a compression rate of less than one third. Even in early mobilization there is normally no increase in deformity. 8.3 per cent with an increase in deformity had an osteoporosis or a compound fracture. Unstable fractures are stabilized by springs and plates. In cases with great deformity surgical treatment has to be discussed, too.

Adult↗
PubMed1980

[The posttraumatic "psychogenic club-foot" (author's transl)].

Two cases of posttraumatic "psychogenic clubfoot" deformity are reported. Case I. A woman, aged 44, with foot deformity after infantile paralysis on the right side sustained an inversion injury to the left ankle in April 1979. Two weeks later she was admitted to our hospital. She was unable to walk and examination showed a drop foot with supination contracture of the left foot. Neurological examination was normal inclusive electromyogram. Ligaments of the ankle and peroneal tendons were reviewed by operative procedure under suspicion of rupture. There were no pathological findings, no hematomas or other traumatic signs. The neurological control examination was normal and psychogenic contracture was diagnosed. The personal history showed a corresponding problematical psychic background. Case II. A man, aged 24, was admitted to our hospital 3 months after an inversion injury to the right ankle. Examination showed a drop foot with supination contracture (Fig. 1 a, b). He walked with two crutches. Roentgenograms were normal, the ankle had normal stability, and neurological examination showed no pathological findings. There were no signs of an organic lesion. Psychogenic club-foot was diagnosed. Both patients were treated functionally with active exercises and psychological care. The follow-up control 1 resp. 1/2 year after injury showed normal muscles and free active mobility in both cases (Fig. 1 c, d).

Adult↗