Search PubMed⌕ Search

Biomedical subjects

B D Cohen

Publications and source records attributed to B D Cohen.

At least 55 records · Page 3Linked to original sources
PubMed1987

Hepatitis A virus in stool during clinical relapse.

Among 256 patients with acute hepatitis A, 17 (6.6%) had a relapse of the disease between 30 and 90 days after the primary episode. We studied 7 of these patients. Serologic testing showed mean alanine aminotransferase levels of 1668 IU/L during the acute stage, 107 IU/L during the early convalescence, and 1027 IU/L during the relapse. Tests for IgM antibody against hepatitis A virus were positive in the 7 patients at the onset of disease, with decreasing levels in 3 of the 4 patients tested during the evolution of the illness. Stools collected during the relapse phase showed hepatitis A virus by immune electron microscopy, radioimmunoassay, and molecular hybridization using a 32P-labeled cDNA-hepatitis A virus probe. Stools collected from 4 of these patients 6 to 12 months after the onset of disease were negative for the virus. The finding of hepatitis A virus in the stool of these patients during the relapse phase strongly implicates hepatitis A virus as the causative agent of the clinical relapse.

Adolescent↗
PubMed1987

Personal identity and the schizophrenic process: an integration.

In this paper we explore the relation between theories of self, particularly identity theory, and the schizophrenic process. A fundamental assumption in identity theory is that a person's self includes a hierarchically organized set of identities. When an individual's set of identities is limited in range and/or diffusely organized he/she is thought to be at risk for schizophrenia. The onset and relapse of schizophrenic episodes are assumed to occur when important identities are negated. Implications of identity theory for integrating extant conceptions of schizophrenia are discussed. Also discussed are the effects of medication in establishing a patient identity and the role of the patient identity in preventing psychotic relapse.

Adaptation, Psychological↗
PubMed1983

Hepatitis B virus: a possible cause of serositis in hemodialysis patients.

An epidemiologic survey in a maintenance hemodialysis population of 300 patients was undertaken to relate the appearance of acute serositis (pericarditis, pleuritis or ascites) to HBsAg antigenemia. A significant number of incidents of serositis occurred in patients acutely or chronically infected with hepatitis B surface antigen (HBsAg) suggesting an etiologic role for the virus in the serositis of uremia. In 2 patients with both end-stage renal disease and chronic HBsAg antigenemia, immunofluorescent studies of serosal tissues showed fluorescent clusters interpreted to be HBs antigen-antibody complexes. It is concluded that an immunologic response to viremia may be one of the causes of serositis in uremia.

Adult↗
PubMed1981

Group treatment of erectile by dysfunction for men without partners: a controlled evaluation.

This study utilized a control group design to evaluate the effectiveness of group treatment of erectile dysfunction in men without partners. Twenty-one men with secondary erectile dysfunction were randomly assigned to one of two men's groups with different cotherapy teams or to a waiting-list control condition. Results indicated that while the two men's groups did not differ on any clinical-outcome measures, each men's group improved significantly more than the waiting-list clients on a variety of measures concerning sexual attitudes and behaviors related to erectile dysfunction. Furthermore, most of the treatment gains for men's group participants were maintained at six-week and six-month follow-up evaluations. However, the men's group and waiting-list participants did not differ significantly in the reported frequency of erection difficulties following treatment. In comparing the present findings with those of previous studies of men's group treatment, it is hypothesized that the absence of significant change in the frequency of erection difficulties in the present study may have been attributable to the older age of our clients or to the relative lack of emphasis on dating-skills training in this treatment format. This study illustrates the importance of including some form of no-treatment control condition in the evaluation of new treatments for sexual dysfunction.

Adult↗
PubMed1981

Dating skills training in the group treatment of erectile dysfunction for men without partners.

This study was a controlled evaluation of men's group treatment of erectile dysfunction that emphasized communication and dating skills training for men without partners. Following a 6-week pretreatment waiting period, 11 men were seen for 10 sessions in two men's groups led by different cotherapy teams. Several female guest therapists attended three sessions to help the men role-play a sequence of difficult social interactions. A series of communication/dating homework assignments was added to the weekly sensual/sexual assignments. The results indicated no improvement during the waiting control period, but significant improvement on measures of sexual attitudes and behaviors following treatment. There was a significant reduction in the frequency of erection difficulties before intercourse and a trend toward reduction of erection difficulties during intercourse. These improvements were maintained over a 6-month follow-up.

Adult↗
PubMed1977

A method for the study of lay conceptions of psychopathology: a free-response approach.

A free-response approach for identifying a lay group's conception of psycopathology is described in this paper and is illustrated with a college student population. An initial sample of individuals from the population is asked to give "reasons why someone might need to be examined by a professional person in the field of mental health." A second sample of individuals sort the problem statements on the basis of their judgements of the similarity among the statements. A measure of psychological distance for each pair of statements, based on the proportion of times the two statements are sorted together, is used as input for clustering and multidimensional scaling. A third sample contributes to the interpretation of the resulting structures by rating each problem on several psychological properties. The most relevant properties found for college students are: (a) degree of abnormality; (b) referral source--self versus others. Also disc1ssed are possible applications of the method to other lay groups in the interest of providing improved community mental health services to such groups.

Attitude to Health↗
PubMed1977

Alternate reasons for atherogenesis in uremia.

The key to symptomatology in uremia is nitrogen retention leading to amidination and transmidination of a variety of substrates. The product of this activity is a series of guanidino acids which are methyl receptors converting S-adenosylmethionine to adenosine and homocysteine. Adenosine is a potent inhibitor of the enzyme ATPase and, in this way, contributes to the anemia, the bleeding diathesis and the CNS symptoms of uremia. Homocysteine is an inhibitor of pyridoxal phosphate-induced reactions and contributes to the angiitis and thromboembolism so unexpectedly encountered in chronic uremia.

Adenosine Triphosphatases↗