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Biomedical subjects

B D Brause

Publications and source records attributed to B D Brause.

31 records · Page 2Linked to original sources
PubMed1983

Two-stage reimplantation for the salvage of infected total knee arthroplasty.

The results of eleven two-stage reimplantations to salvage eleven infected total knee arthroplasties in ten women (seven with osteoarthritis and three with rheumatoid arthritis) were evaluated after an average follow-up of thirty-four months. The staged procedures included removal of all of the components of the prosthesis and all cement, then six weeks of parenteral antibiotic therapy (monitored by maintaining serum bactericidal levels at a peak dilution of 1:8), and finally reimplantation with a total condylar-type prosthesis. All antibiotics were discontinued after reimplantation. At follow-up, no patient had had a recurrence of the original infection, but one had a hematogenous infection with a different organism secondary to an infected bunion. The results after reimplantation were rated excellent in five knees, good in four, and fair in two. Weakness of the extensor mechanism with an extension lag was the most frequent complication. We do not believe that antibiotic therapy alone is adequate for the management of an infection around a prosthesis. The method described appears to be effective but it is costly and time-consuming. The surgical procedures and medical management are technically difficult, often special equipment and a custom-made prosthesis are required, and there are no shortcuts.

Aged↗
PubMed1982

Infection rates after 3175 total hip and total knee replacements performed with and without a horizontal unidirectional filtered air-flow system.

To determine the effect of the ventilation system on infection rates after total hip and total knee arthroplasties performed in operating rooms with and without a horizontal unidirectional filtered air-flow system, using modern antiseptic conditions and antibiotic prophylaxis, all of the single-stage procedures (3175 of a total of 4769) were subjected to statistical analysis and fifty-seven matched pairs for controls were established. A reduced infection rate after total hip replacement (from 1.4 to 0.9 per cent) and an increased infection rate after total knee replacement (from 1.4 to 3.9 per cent) were found when patients operated on in the filtered laminar air-flow operating room were compared with those whose operations were done in two conventional rooms. This pattern was statistically significant and was believed to be due to the positions of the operating team and of the wound with respect to the air flow. Prospectively accumulated factors (such as the experience of the surgeon, the duration of surgery, the diagnosis, and the patient's age) as well as retrospectively accumulated factors (such as predisposing conditions of the patient) did not explain the observed patterns of infection.

Adult↗
PubMed1982

Reimplantation in infection: a 12-year experience.

Three groups of patients underwent reimplantation for infected hip prostheses during the period from 1968 to 1979. The first group (N = 19) was diagnosed mainly by hip aspiration and treated with antibiotics selected by disc sensitivity and one-stage reimplantation in 14 hips. The second group (N = 26) was diagnosed by strict hip infection criteria and treated with a similar antibiotic regimen. Reimplantation was performed in one stage in 13 patients and in two stages in the remaining 13. The third group (N = 16) was diagnosed by the same criteria but treated with standardized bactericidal antibiotics evaluated by the tube dilution method. There were five one-stage reimplantations, ten two-stage, and one radical debridement without removal of components. The follow-up period ranged from two to 12 years. The present guidelines for reimplantation include subacute hip sepsis caused by susceptible bacteria, according to tube dilution methods in immunocompetent patients with adequate soft tissue and bone stock to allow a satisfactory biomechanical reconstruction. Patients should be aware of the risk of recurrence of infection, persistent pain, limited durability, and further surgical treatment.

Aged↗
PubMed1980

Comparative study of diarrhea associated with clindamycin and ampicillin therapy.

The incidence of diarrhea associated with clindamycin and ampicillin was studied prospectively among 606 adult inpatients during a 12-month period. Clindamycin was administered to 288 patients of whom 145 received clindamycin in combination with ampicillin. A comparable group of 318 patients received ampicillin alone. Underlying diseases, diets and medications other than antibiotics studied were implicated in the etiology of diarrhea in 25--40% of patients. The incidence of diarrhea due to ampicillin and clindamycin was 3.8 and 4.2%, respectively (P greater than 0.05). The incidence of diarrhea in patients who received both drugs was 9.0% (P less than 0.05). Diarrhea which developed after completion of antibiotic therapy was two-to-three fold longer in duration than that which occurred during drug administration. This finding underscores the necessity to follow patients closely for at least four to six weeks after receiving such medications.

Adolescent↗
PubMed1978

Attachment of virulent Treponema pallidum to human mononuclear phagocytes.

The predominant phagocyte in established human syphilitic lesions is the mononuclear phagocyte. As these leucocytes may be important in immunity to Treponema pallidum, the initial interaction between human phagocytes and pathogenic T. pallidum (Nichols strain) was studied in vitro. Motile, virulent T. pallidum attach to the surface membrane of phagocytes but are not ingested by these cells. Heated, non-motile treponemes are not cell-associated but are observed free in the extracellular medium. Attachment is polar, at one or both terminal portions of the treponeme, and is neither serum- nor complement-dependent. Ingestion of virulent treponemes was not observed by phase-contrast or by electron microscopy in the presence of normal human or rabbit serum and complement. Techniques were chosen to preserve both the fragile surface constituents of the treponeme and the phagocytic function of mononuclear cells. Unfixed preparations were observed by phase-contrast microscopical examination during incubation to differentiate motile from non-motile organisms and fixed preparations were used for quantitation of attachment. This model should be useful for studying humoral and cell-mediated immunity in syphilis.

Cell Adhesion↗
PubMed1977

Antimicrobial therapy of vitamin B6-dependent streptococcal endocarditis.

Vitamin B6-dependent viridans streptococci were isolated from two patients with microbial endocarditis. Because of their unique requirement for pyridoxal hydrochloride, these organisms did not grow normally in the media usually used in diagnostic laboratories. When tested in supplemented media, both strains were resistant to penicillin G and relatively sensitive to streptomycin. Penicillin-streptomycin synergy was demonstrated in vitro as well as in experimental endocarditis. These laboratory findings confirmed the clinical observations in these two patients that penicillin-streptomycin therapy should be used in vitamin B6-dependent streptococcal endocarditis. Nutritionally varient streptococci may be important pathogens in microbial endocarditis and must be considered in patients with suggestive clinical findings but negative blood cultures.

Adult↗
PubMed1976

Relative efficacy of clindamycin, erythromycin, and penicillin in treatment of Treponema pallidum in skin syphilomas of rabbits.

The currently recommended antibiotic for treatment of fetal syphilis in pregnant women who are allergic to penicillin is erythromycin. However, clindamycin crosses the placenta more effectively than erythromycin. Therefore, an in vivo rabbit model of intradermal syphilomas was used to determine the effect of clindamycin compared with the effects of erythromycin and penicillin on the growth of virulent Treponema pallidum. The average number of motile treponemes in two, paired, mature lesions was determined before and after therapy in groups of four rabbits per dosage. Single intramuscular doses of clindamycin (15 and 40 mg/kg) and erythromycin (12 and 40 mg/kg) did not decrease treponeme counts significantly. Single injections of penicillin (10,000 units/kg) reduced treponemal counts by more than 250-fold. Multiple intramuscular injections of clindamycin reduced counts by five- to sevenfold, whereas multiple doses of erythromycin and penicillin decreased treponeme counts by greater than 300-fold. These studies indicate that clindamycin is far less active than erythromycin or penicillin in treatment of established syphilitic lesions in rabbits.

Animals↗
PubMedDate not supplied

Septic arthritis after arthroscopic anterior cruciate ligament reconstruction. Diagnosis and management.

We performed a retrospective study of knee joint infections after arthroscopic anterior cruciate ligament reconstruction at our institution. Two thousand five hundred anterior cruciate ligament reconstructions were performed between 1988 and 1993. Seven (0.3%) patients experienced postoperative deep infections of the knee. All anterior cruciate ligament reconstructions were performed using arthroscopically assisted techniques. Six (86%) of these patients had concomitant open procedures performed, including meniscal repair, posterolateral corner reconstruction, and medial collateral ligament reconstruction. Four patients had acute (< 2 weeks), two patients had subacute (2 weeks to 2 months), and one patient had late (> 2 months) infections. All patients had positive cultures from knee joint aspirates with the organisms Staphylococcus aureus, Staphylococcus epidermidis, Peptostreptococcus, or a combination thereof. All patients underwent immediate arthroscopic irrigation and debridement. All infections were intraarticular; six patients also had extraarticular sites of infection. Four patients underwent repeat irrigation and debridement at approximately 1 week. The anterior cruciate ligament graft was removed from four patients. All patients were treated with intravenous antibiotics for 4 to 6 weeks, protected weightbearing, and physical therapy. At a mean followup of 29 months, mean knee extension was 0 degree, and mean knee flexion was 122 degrees (range, 70 degrees to 135 degrees). Six (86%) patients had minimal to no pain in their operative knee, and they were satisfied with their functional results.

Adolescent↗