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Biomedical subjects

B Czerniak

Publications and source records attributed to B Czerniak.

77 records · Page 5Linked to original sources
PubMedDate not supplied

Fine needle aspiration cytology of intraocular malignant melanoma.

The techniques used for fine needle aspiration biopsy of 19 intraocular tumors clinically suspected to be malignant melanomas are described. Aspirates of 16 tumors yielded adequate material for the cytologic diagnosis of malignant melanoma. Malignant cells of the epithelial type and of a spindle shape were found in the smears. The main cytologic features of the epithelial-type cells were eccentrically located nuclei, distinct nucleoli, binucleation and multinucleation. The spindle-shaped cells, dispersed or arranged in clusters, were characterized by centrally placed, oval or rodlike nuclei, with or without nucleoli. Three types of smears were distinguished: (1) those with a predominance of epithelial-type cells, (2) those with a predominance of spindle-shaped cells and (3) those with mixed epithelial-type and spindle-shaped cells. Our observations prove that precise morphologic diagnosis of intraocular malignant melanoma and its cellular types can be established by fine needle aspiration biopsy. However, we do not advocate fine needle aspiration biopsy as a routine diagnostic procedure in all intraocular melanomas. This method should be reserved for only cases that cannot be definitely diagnosed by conventional techniques or in which the cellular type of melanoma must be defined in order to choose the proper method of treatment.

Biopsy, Needle↗
PubMedDate not supplied

[Ultrastructure of ependymoma myxopapillare].

The results of histological and ultrastructural investigations of a tumour of the type of myxopapillary ependymoma growing initially extradurally in the end-part of the vertebral canal are reported. The patient has been observed for 13 years. During the disease several recurrences and distant metastases outside the central nervous system were observed. Histological examinations were carried out of the primary tumour and recurrences or metastases and always an evident papillary structure of tissue was found with characteristic "oedematous" stroma. In submicroscopic investigations attention was called to the stroma and to the ultrastructure of neoplastic cells. Slit-like spaces with numerous microvilli protruding into their lumen were observed between the neoplastic cells lying pallisade-like on the surface of papillae. These slits seemed on cross-sections to be minute tubular structures. This submicroscopic feature was not paid attention to in two previous papers discussing the ultrastructure of myxopapillary ependymoma.

Adult↗
PubMedDate not supplied

Fine needle aspiration cytology of malignant melanoma of the skin.

Fifty malignant melanomas of the skin were aspirated with a fine needle, and the cytomorphologic features of the smears were evaluated. An attempt was made to establish the frequency of morphologic features found in melanoma cells. The following features were regarded as frequent: lack of cohesiveness between the malignant cells; binucleated, multinucleated and giant cells; and intranuclear "vacuoles." The nuclei usually had a regular outline, and the nuclear chromatin was evenly distributed. The majority of the smears contained a mixture of epithelial-type and spindle cells. The nuclei of the epithelial-type cells were usually in an eccentric position. The morphologic features of malignant cells in smears, as described, can be helpful in making the preoperative cytologic diagnosis of nonpigmented malignant melanoma of the skin.

Biopsy, Needle↗