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Biomedical subjects

B Currie

Publications and source records attributed to B Currie.

At least 37 records · Page 2Linked to original sources
PubMed1989

Acetylator phenotype and short-course chemotherapy for tuberculosis in Papua New Guinea.

In Papua New Guinea the slow acetylator phenotype is unusual and peripheral neuropathy during isoniazid therapy is uncommon. Acetylator status and other factors influencing isoniazid-induced peripheral neuropathy are discussed, and statistics from Papua New Guinea are presented. The relevance of acetylator phenotype to other side-effects of isoniazid is less well defined. Prophylactic pyridoxine supplementation during short-course chemotherapy for tuberculosis is not generally necessary in the daily 'A' regimen, but should be maintained in the twice-weekly (high-dose isoniazid) 'B' regimen for adults and children over 20 kg.

Acetylation↗
PubMed1988

A focus of Rocky Mountain spotted fever within New York City.

In the spring and summer of 1987, four persons acquired Rocky Mountain spotted fever within New York City, an area in which the disease had not previously been known to be endemic. Three of the four patients were residents of the Soundview area of the Bronx. All diagnoses were confirmed by indirect fluorescent-antibody tests. Environmental investigation revealed that the tick vector for Rickettsia rickettsii, Dermacentor variabilis, was present in a local park. Of the 66 specimens of D. variabilis collected, 5 (8 percent) were positive for rickettsiae from the spotted fever group. Of an additional 96 specimens of D. variabilis, 5 (5 percent) were found positive for rickettsiae by a more specific monoclonal antibody assay. Eight additional New York City parks in all five boroughs were searched for ticks. D. variabilis was found in only one other park; of the 147 ticks collected there, none were positive for rickettsiae. These findings emphasize the focal nature of Rocky Mountain spotted fever and the need to consider that disease in the differential diagnosis of any obscure acute febrile illness, even in the absence of a history of travel to known endemic areas.

Adult↗
PubMed1988

Resolution of neurotoxicity with anticholinesterase therapy in death-adder envenomation.

A case of the reversal of death-adder (Acanthophis antarcticus) neurotoxicity by treatment with neostigmine methylsulphate in a Papua New Guinean villager is described. While antivenom remains the mainstay in the treatment of snake-bite envenomation, the possible role of anticholinesterase therapy for death-adder bites in Papua New Guinea is discussed. In addition, some problems with first-aid management are outlined.

Adult↗
PubMed1984

Seasonal patterns of asthma: a clue to etiology.

An extensive data set of daily hospital emergency room visits for asthma for two geographic areas (1953-77 in New Orleans and 1969-77 in New York City) was examined for seasonality. Previous studies using smaller data bases have reported an autumn increase (principally during October and November) in the number of emergency room visits for asthma in many locations in this country (including New Orleans and New York City). The results of this study indicated that for every hospital and every year of observation in New York City the number of asthma emergency room visits increased in September, reached a peak in October and November and declined in December. In contrast, in New Orleans an autumn increase in the number of asthma emergency room visits was not consistently observed, being absent or reduced during many years. The distribution of asthma epidemic days (days on which the number of asthma emergency room visits was greatly elevated) by month was also examined. In New York City, there was a tendency for these days to occur during September, October, and November while in New Orleans there was an equal likelihood of epidemic days occurring in April, May, and June as well as during September, October, and November. The observations tend to suggest different etiologies for asthma attacks in the two geographic areas.

Adolescent↗