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Biomedical subjects

B Cribier

Publications and source records attributed to B Cribier.

At least 127 records · Page 7Linked to original sources
PubMed1994

[Efficacy and tolerance of terbinafine (Lamisil) in a series of 50 cases of dermatophyte onychomycoses].

Terbinafine is an antifungal agent of the allylamine class, which is fungicidal when administered per os. Because of its pharmacokinetic properties, terbinafine proved successful in onychomycoses. The purpose of this study was the evaluation of terbinafine efficacy and tolerance in dermatophyte onychomycoses, in a monocenter open study. Fifty patients have been treated with 250 mg terbinafine daily. Feet were involved in 43 cases, hands and feet in 6 cas, and hand alone in 1 case. Trichophyton rubrum has been isolated in 46 malades, and Trichophyton mentagrophytes in 4 patients. The severity of onychomycoses has been evaluated as follows: involvement of the first toenail (44 cases), total involvement of the nail plate (38 cases), ineffective or non tolerated previous antifungal treatments (37 cases), chronic evolution (mean duration 6.5 years), multiple nails involved (average 6). The mean duration of treatment was 22.2 weeks (range 4 to 8 months). Mycological cure rate was 92 p. 100, and complete cure rate was 86 p. 100. The mean time to mycological cure was 22.4 weeks and the mean time to complete cure was 31.5 weeks. Tolerance was good: minor side effects were noted in 3 patients, and 1 developed reversible agueusia; a moderate elevation of ALAT and ASAT occurred in 1 case. Other drugs were simultaneously administered in 15 patients: no side effects due to drug interactions have been observed. Terbinafine proved highly successful and well tolerated even in those onychomycoses which were difficult to treat. High cure rates were obtained with an average of 5 month-treatment.

Adult↗
PubMed1993

[Squamous syringometaplasia: an original manifestation of pathomimesis].

INTRODUCTION: Epidermoid syringometaplasia consists in rare changes of the eccrine sweat glands, which show keratinization of their ductal part. Many conditions are associated with epidermoid syringometaplasia: chronic ulcers, scars, keratoacanthoma and various drugs or toxic agents, suggesting a toxic effect of drugs or an inflammatory mechanism. OBSERVATION: A 22-year-old woman presented with large painless ulcero-vegetating lesions of the forearm; the X-ray examination showed an major emphysema. She also had multiple scars on her trunk and limbs. The curious features of the lesions and the psychiatric troubles suggested the diagnosis of dermatitis artefacta. Histopathological examination showed a pseudocarcinomatous epidermal hyperplasia; in the deep dermis the eccrine ducts were connected to the epidermal cell masses or seemed to be included into the proliferation. Keratinization was noted within the keratinocytes surrounding the duct lumen. A dense inflammatory cell infiltrate was observed, containing many macrophages with a foamy cytoplasm, probably resulting from the injection of a foreign substance. All lesions healed within a few days using an occlusive dressing. COMMENTS: In this patient, the voluntary injection of an unknown substance probably induced these metaplastic changes of the sweat ducts, which are probably related to a toxic mechanism. Epidermoid syringometaplasia has never been described after cutaneous injections.

Adult↗
PubMed1993

[Cutis verticis gyrata: reduction surgical treatment].

Cutis verticis gyrata (CVG) is a rare cause of acquired scalp thickening; in its primary form, the disease does not show any bone involvement. A 19-year old man had noticed a moderate thickening of the scalp at the age of 15. He progressively developed ridges and furrows in the occipital and parietal areas: after a four-year period, there were ten sagittal and irregularly parallel folds. There was neither pain nor pruritus, and the hair had a normal appearance. Complete neurological examination was unremarkable and the patient was of normal intelligence. All biological investigations, including STH and TSH levels, were normal. X-ray examination and tomodensitometry did not show any bone involvement. Our patient was treated by surgical reduction of the scalp areas involved under general anesthesia, with a very good result. This is a typical case of primary CVG. Differential diagnosis of primary cutis verticis gyrata comprises pachydermoperiostosis, cerebriform intradermal nevus and many secondary conditions associated with hypertrophy and folding of the scalp. A relatively simple surgical treatment results in a major reduction of the scalp thickening, and avoids maceration.

Adult↗
PubMed1993

[Peno-gingival syndrome. A male equivalent of vulvo-vagino-gingival syndrome?].

A 52-year-old man presented with a chronic erosive gingivitis associated with eroded genital lesions which caused preputial adhesions. Histological examination of the gingival lesions showed typical changes of erosive lichen planus. A few months later, pseudo-peladic alopecia of the vertex and lichen planus lesions of the mouth appeared. Local steroids were ineffective to treat oral erosions, but the lesions were not painful. After one year, all changes remained unchanged. We therefore propose the diagnosis of erosive lichen planus involving the mucous membranes of mouth and genitalia; this association was never reported in male patients. This syndrome represents the exact male equivalent of the vulvo-vagino-gingival syndrome described in women. "Genito-gingival syndrome" is therefore proposed for this new clinical form of erosive lichen planus.

Atrophy↗
PubMed1993

[Multiple complications of a mycoplasma pneumoniae infection].

We report the case of a patient who was admitted to hospital for a pneumonia in association with a Stevens-Johnson syndrome. The association of these conditions suggested a Mycoplasma pneumoniae infection, which was confirmed on serology. There were three other extra-respiratory complications discovered: cold agglutinins, a disturbance of liver function tests, and circulating anticoagulant; both the two latter and the Stevens-Johnson syndrome are rare complications.

Anemia, Hemolytic, Autoimmune↗
PubMed1992

Staphylococcus aureus leukocidin: a new virulence factor in cutaneous infections? An epidemiological and experimental study.

Panton-Valentine leukocidin (PVL) is a Staphylococcus aureus (SA) exotoxin, which kills human granulocytes and monocytes in vitro. Among 43 SA strains from cutaneous infections, 12 were PVL producers, whereas among 49 blood culture strains, only 1 produced PVL. Most PVL-producing strains (11/22) came from 22 primitive cutaneous infections, especially furuncles and abscesses, while only 1 PVL-producing strain came from 21 secondary infections of dermatoses such as bullous or pruritic diseases. Intradermal injections of PVL in rabbits induced edema, erythema and necrosis; histopathological changes at the injection sites consisted mainly in leukocytoclasis and vascular necrosis. All changes were dose dependent, and previous immunization of rabbits partially neutralized PVL-induced effects. Production of PVL in vivo after injections of bacteria seems to be low, and the histopathological lesions induced in the rabbit skin do not appear to be specifically related to PVL activity. However, PVL is a good candidate as a new virulence factor in cutaneous SA infections.

Animals↗
PubMed1992

Renal impairment probably induced by etretinate.

A 83-year-old patient had been treated for pityriasis rubra pilaris with 70 mg etretinate daily. He developed acute renal impairment, with creatinine levels reaching 73 mg/l on day 7. After discontinuation of etretinate, all biological changes were reversible. Although renal impairment is not considered as retinoid side effect, the chronology of renal changes is very suggestive of etretinate responsibility.

Acute Kidney Injury↗
PubMed1992

[Immunohistochemistry of nodular vasculitis. A possible role of delayed cellular hypersensitivity].

The physiopathogenesis of nodular vasculitis is still unknown: there is probably an initial Arthus' phenomenon responsible for the lesions of the deep vessels, but the frequent recurrences and the long time duration of the hypodermic nodules are still not understood. Dendritic protein S100 positive cells had previously been observed within hypodermal granulomas. The purpose of this study was to confirm these observations in a large group of nodular vasculitis, and to compare the expression of S100 protein in other vascular diseases and in pure panniculitis. Immunohistochemical staining for S100 protein was performed on paraffine-embedded samples: 45 cases of nodular vasculitis, 21 of panniculitis, 10 of superficial leucocytoclastic vasculitis, 10 of periarteritis nodosa, and 10 of erythema nodosum were analyzed by means of optic microscopy. Numerous dendritic S100 protein positive cells were found within hypodermal granulomas in most of the cases of nodular vasculitis, but these cells were absent in the 3 cases of initial deep leucocytoclastic vasculitis lesions of nodular vasculitis. The mean percentage of these cells was 4.5 p. 100 in the hypodermal inflammatory areas; they were observed mainly around vascular lesions. Hypodermal dendritic cells were absent or less numerous in all other cases, and a high number of such cells seems to be observed only in nodular vasculitis. Because of their dendritic morphology, and the high expression of S100 protein, these cells could be interdigitated cells, which are known to present antigens to T-lymphocytes. They could play an important role in generating the chronicity of nodular vasculitis, by a mechanism of delayed cell-mediated hypersensitivity, after the initial lesions caused by immune complexes.

Dendritic Cells↗