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Biomedical subjects

B Cox

Publications and source records attributed to B Cox.

At least 91 records · Page 5Linked to original sources
PubMed1996

The squalestatins: decarboxy and 4-deoxy analogues as potent squalene synthase inhibitors.

Squalestatins without either the hydroxy group at C-4 or the carboxylic acid at C-3 or C-4 were prepared and evaluated for their ability to inhibit rat liver microsomal squalene synthase (SQS) in vitro. These modifications were well tolerated for compounds with the 4,6-dimethyloctenoate ester at C-6 (S1 series). However in analogues without the C-6 ester (H1 series), removal of the C-4 hydroxy group gave compounds with reduced potency, whereas decarboxylation at C-3 resulted in a dramatic loss of SQS inhibitory activity. In comparison with S1 1, C-4 deoxyS1 3 and C-3 decarboxyS1 10 have shorter in vivo durations of action on the inhibition of hepatic cholesterol biosynthesis in rats. C-4 deoxyS1 3 retains good serum cholesterol-lowering ability in marmosets, while C-3 decarboxyS1 10 showed only a marginal effect even at high dose.

Animals↗
PubMed1996

Childhood leukaemias in New Zealand: time trends and ethnic differences.

Registrations from the New Zealand Cancer Registry were used to examine time trends in the incidence of leukaemias among children aged 0-14. There was a statistically significant increase in the incidence of leukaemia among children aged 0-4 during 1953-57 to 1988-90. In this age group, the recorded incidence rate increased from 4.89 per 100,000 person-years in 1953-57 to 7.92 in 1988-90. During 1973-77 to 1988-90 (and probably in earlier years), the increase was due to an increase in acute lymphoblastic leukaemia (ALL). The trends were unlikely to be due to changes in diagnosis or case ascertainment. The childhood leukaemia trends might be related to trends in family size, maternal age, socioeconomic level or exposure to infections. However, there are uncertainties about the importance of these factors or about their trends. The incidence of acute non-lymphoblastic leukaemia (ANLL) decreased between 1968-72 and 1988-90. The time trends highlight the likely importance of environmental factors in the aetiology of childhood leukaemias in New Zealand. The risk of ALL was lower in the Maori than in the non-Maori population (relative risk Maori/non-Maori 0.74). The risk of ANLL was higher among Maori (relative risk 1.84).

Adolescent↗
PubMed1995

A community survey of sun exposure, sunburn and sun protection.

AIM: To describe outdoor activities, sun protection behaviours and the experience of sunburn in a sample of New Zealanders during summer weekends of 1994. METHODS: 1243 respondents to a telephone survey provided information regarding their outdoor activities for the 5 hour period around midday of the previous Saturday and Sunday. The sample was drawn from those aged 15 to 65 years in the five centres of Auckland, Hamilton, Wellington, Christchurch and Dunedin. Respondents provided information on sun exposure, sunburn, sun protection and beliefs about tanning, as well as background demographic information, skin type and previous experience of sunburn. RESULTS: 12% of the sample (or 17% of all those outdoors) reported being sunburned on the preceding weekend, and those sunburned tended to be men, and to be under age 35 years. The face, neck and limbs were the areas most frequently reported as burned. Sporting activities and beach or water activities were associated with the highest number of episodes of burning. Overall 38% of those outside reported wearing a hat and 32% reported the use of a sunscreen. Positive attitudes to tanning were quite common and probably present the main target for change in the community. CONCLUSION: On any sunny weekend in summer about three-quarters of adult New Zealanders will be out in the sun for relatively long periods of time, and many will get sunburned. The reduction of such harmful sun exposures remains an important public health goal.

Adolescent↗
PubMed1995

Trends in oral cancer by subsite in New Zealand.

A significant increase in incidence rates for all subsites of oral cancer in men and all but cancer of the salivary glands in women has occurred in New Zealand over the past 35 years. However, only male mortality rates of cancers of the nasopharynx and pharynx (excluding the nasopharynx) have significantly increased during this time period. Significant birth-cohort effects existed in the trends in incidence and mortality for cancers of the tongue, mouth, pharynx (excluding the nasopharynx), and nasopharynx among men. For cancers of the mouth and pharynx (excluding the nasopharynx) an increased risk for men born 1912-1932 existed, while an increased risk of cancer of the tongue occurred for men born 1922 onwards. For nasopharyngeal cancer, men born around 1912 and those born from about 1932 onwards were found to have an increased risk. For women, no consistent trends by birth-cohort were found for any oral subsite of cancer.

Adult↗
PubMed1995

Suicide among New Zealand Maori: is history repeating itself?

Suicide rates for New Zealanders identified as Maori were analysed for the period 1957-91 and compared with those for non-Maori people. Overall, Maori men had about half the risk of suicide of non-Maori men, and Maori women one-third the risk of non-Maori women. Nevertheless, there was a sharp increase in suicide rates for Maori aged 15-24 years during the period studied, with rates for the 1987-91 time period of 35.2/100,000 for men and 6.0/100,000 for women. These were similar to the high suicide rates of young non-Maori New Zealanders. Suicide among Maori in pre-European times appears to have been embedded in traditional culture and may have occurred particularly among bereaved women; today the pattern is one of high rates in young men who are likely to have been alienated from their culture.

Adolescent↗
PubMed1994

Cervical cancer in New Zealand: national and regional trends.

AIMS: To assess the impact of past cervical screening on national and regional trends in mortality and incidence of cancer of the cervix uteri. METHODS: Age-specific mortality and incidence rates were calculated for the total female New Zealand population and the nonMaori populations of the regional health authorities. Analyses of the trends for different birth-cohorts and regions were conducted. RESULTS: Cervical cancer mortality rates for women born about 1919 to 1929 at older ages were lower than expected from their mortality at younger ages. Birth-cohorts born about 1939 to 1944 and 1954 to 1959 experienced some reduction in cervical cancer mortality at younger ages which may not have been sustained at older ages. No obvious effect of screening was present for generations of women born about 1949. Regional differences in trends in cervical cancer were observed. CONCLUSIONS: A reduction in cervical cancer mortality from cervical screening has occurred at different ages for some generations of New Zealand women but has not always been sustained as women age. Also, there is some evidence that the effect of screening has varied between regions within New Zealand.

Adult↗
PubMed1994

Cytoplasmic inheritance. Prion-like factors in yeast.

Some non-Mendelian genetic factors in yeast have properties reminiscent of prions; inheritance of these prion-like factors may involve the autocatalytic conversion of a protein from one metastable state to another.

Amino Acid Sequence↗
PubMed1994

Latitude gradients in melanoma incidence and mortality in the non-Maori population of New Zealand.

The variation with latitude of incidence and mortality for cutaneous malignant melanoma (CMM) in the non-Maori population of New Zealand was assessed. For those aged 20 to 74 years, the effects of age, time period, birth-cohort, gender, and region (latitude), and some interactions between them were evaluated by log-linear regression methods. Increasing age-standardized incidence and mortality rates with increasing proximity to the equator were found for men and women. These latitude gradients were greater for males than females. The relative risk of melanoma in the most southern part of New Zealand (latitude 44 degrees S) compared with the most northern region (latitude 36 degrees S) was 0.63 (95 percent confidence interval [CI] = 0.60-0.67) for incidence and 0.76 (CI = 0.68-0.86) for mortality, both genders combined. The mean percentage change in CMM rates per degree of latitude for males was greater than those reported in other published studies. Differences between men and women in melanoma risk with latitude suggest that regional sun-behavior patterns or other risk factors may contribute to the latitude gradient observed.

Adult↗
PubMed1994

Effect of aerobic training on baroreflex regulation of cardiac and sympathetic function.

To investigate the effect of aerobic exercise training on baroreflex regulation of muscle sympathetic nerve activity (MSNA) and cardiac R-R intervals in a middle-aged to older population, 10 healthy men > 40 yr of age underwent tests of autonomic function before and after 12 wk of high-intensity training. Cardiac and peripheral baroslopes were determined from the R-R interval vs. mean arterial pressure (MAP) and peroneal MSNA vs. diastolic pressure relationships, respectively, during sequential bolus injections of nitroprusside and phenylephrine. Maximal oxygen uptake increased (P < 0.05) 17% with training. Resting R-R interval increased (881 +/- 23 to 956 +/- 38 ms, P < 0.05), MAP decreased (96 +/- 2 to 91 +/- 3 mmHg, P < 0.05), and MSNA was unaltered (23.1 +/- 2.3 to 23.6 +/- 1.9 bursts/min) with training. Before and after training, respectively, cardiac baroslopes determined with decreasing (8.7 +/- 0.9 to 9.9 +/- 5.5 ms/mmHg) and increasing MAP (9.6 +/- 2.1 to 9.9 +/- 2.2 ms/mmHg) and the peripheral sympathetic baroslope (-3.3 +/- 0.4 to -3.5 +/- 0.6 bursts.min-1 x mmHg-1) did not differ. The results suggest that short-term aerobic training does not alter resting MSNA or neurocirculatory responses to baroreceptor challenges in middle-aged and older men.

Adult↗