Panel review: a review of past risk assessments and extrapolation problems with radiation.
Explore the source record for details and available documents.
Biomedical subjects
Publications and source records attributed to B Cohen.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Vestibular and optokinetic nystagmus (OKN) of monkeys were induced by platform and visual surround rotation. Vision prolonged per-rotatory nystagmus and cancelled or reduced post-rotatory nystagmus recorded in darkness. Presumably, activity stored during OKN summed with activity arising in the semicircular canals. The limit of summation was about 120 degrees/s, the level of saturation of optokinetic after-nystagmus (OKAN). OKN and vestibular nystagmus, induced in the same or in opposite directions diminished or enhanced post-rotatory nystagmus up to 120 degrees/s. We postulate that a common storage mechanism is used for producing vestibular nystagmus, OKN, and OKAN. Evidence for this is the similar time course of vestibular nystagmus and OKAN and their summation. In addition, stored activity is lost in a similar way by viewing a stationary surround during either OKAN or vestibular nystagmus (fixation suppression). These responses were modelled using direct pathways and a non-ideal integrator coupled to the visual and peripheral vestibular systems. The direct pathways are responsible for rapid changes in eye velocity while the integrator stores activity and mediates slower changes. The integrator stabilizes eye velocity during whole field rotation and extends the time over which the vestibulo-ocular reflex can compensate for head movement.
Restudy of 306 "new immigrant Yemenite" Jews, an ethnic group in which, upon their arrival in Israel, no diabetes was detected, revealed, 25 yr after their immigration, an increased incidence of diabetes and higher plasma and lipoprotein-lipid levels. The prevalence of diabetes (defined as "glucose intolerance") rose to 11.8% (13.2% males and 9.7% females). Obesity in females resulted in increased prevalence of diabetes in all age groups, while in males it affected the older age group only. The male/female diabetic ratio was affected by weight status--in the underweight, diabetes was more prevalent in males, in the overweight, the rate of diabetes in females equaled that of males. In nondiabetics (those with normal glucose tolerance), neither the glucose tolerance nor the insulin response deteriorated with aging. Most diabetics had a delayed insulin response. However, about 50% of nondiabetics and diabetics had insulin response peak at 60 min and similar insulin levels. It appears that in newly discovered adult-onset diabetics in this population there is no shortage of insulin, but rather shortage of insulin action. In nondiabetics, the levels of plasma cholesterol and triglycerides (TG) were higher than levels upon their arrival. In diabetics, the plasma TG, cholesterol, and LDL-cholesterol levels were higher when compared to those of nondiabetics, especially in the group of overweight males. Hyperlipoproteinemia was diagnosed in 27.7% of diabetics and 11.0% of nondiabetics. In diabetics, the HDL/LDL cholesterol ratio was found to be reduced, significantly so in overweight diabetics.
In response to the increasing recognition of the importance of interpersonal skills (IPS) to the physician, there has recently been a rapid growth in the number and variety of medical school teaching programs in IPS. This is a report of a national survey which was part of a study designed to determine the extent and characteristics of IPS-teaching. Most medical schools have specific IPS programs, 80 percent of which are less than five years old. Most teachers in the programs are psychiatrists and psychologists. Most programs teach process (for example, listening, responding), information-gathering, and psychological intervention (for example, demonstrating empathy) skills. Less than one-third teach any specific information-giving/counseling skills. IPS programs are taught mostly in the preclinical years, with a notable lack of formal follow-through into the clinical years. Ninety percent of the programs use videotechnology in teaching or assessing IPS. Only about one-third use any kind of outcome index for evaluation.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
The increasing recognition of the importance of a well-developed set of interpersonal skills to the competent family physician has resulted in a rapid growth in the formal teaching of interpersonal skills within family practice residencies. Of the 168 programs responding to a national survey of family practice residencies, 88 percent indicated that they have formal programs in interpersonal skills. It is estimated that there are well over 500 family practice faculty members who have special responsibilities in teaching interpersonal skills. While most programs address the component skills of the interpersonal process (eg, demonstrating empathy, information gathering, information giving, and psychological intervention), it is of concern that only about half offer explicit training in patient education (53 percent), specific types of counseling (eg, family counseling, 55 percent), or some of the specific interpersonal skills important in team practice and practice management (eg, supervisory skills). One of the most striking findings was that 88 percent of the reporting programs use videotechnology, with 77 percent of these planning to increase their use. Although most programs evaluate their interpersonal skills training using both indirect and direct assessment methods, only 25 percent attempt to use patient outcome as a measure of teaching effectiveness.
Exposure of Israeli agricultural spray pilots and ground crews to parathion was studied. Measurements were made with personal samplers contianing wet midget impingers; samples were analyzed by gas chromatography. Cockpit air exposure levels during 11-21-minute sampling periods for 12 flights ranged from nearly 0 to 430 microgram/m3. During sampling periods of 30 minutes to 4 hours the threshold limit value (TLV) of 100 microgram/m3 was exceeded in 2 of 19 instances. In seven measurements of ground crew exposures, TLV was not exceeded. Air washing with parathion resulted in airborne contamination of the ground level area at more than three times the TLV. Skin exposure data suggested that this route of exposure was significant for ground crew workers but not for pilots. Calculations based on the present data and standard absorption formula suggested that total daily intake for ground crew, but not for pilots, exceeded the Accepted Daily Intake (ADI) of 5 microgram/kg body weight. Sources of exposure and contamination for ground crew and pilots were identified. Recommended environmental control measures for parathion exposure should include cockpit air filtration, modification in flight patterns, paving landing areas, installation of hosing and drainage, NaOH neutralization point, and separate loading and unloading sites. Personal control measures were suggested as a supplement.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
An ecological model suggests looking at the hospitalized mental patient in terms of how well the resources available in the environment fit his individual needs. This study explores the relationship between the environmental fit of patients while they are in the hospital and their adaptation to the community once they have left. Data on individual needs and evaluations of environmental resources were obtained through a series of structured interviews. Results indicate that the more a patient feels the hospital environment is a good fit, the longer he stays there. Hospital fit is positively related to fit in the community, but the latter is related only to the degree of symptomatology exhibited by the expatient in the community and not to how long he is able to remain out of the hospital. Implications of the findings and the model are discussed.
A mother and 2 children with ureteropelvic junction obstruction are described. This is the eighth instance of familial hydronephrosis secondary to ureteropelvic junction obstruction. In this family 10 months elapsed between the diagnosis in the first sister and the realization that an obstruction also was present in the sibling. With the recognition that ureteropelvic junction obstruction can be familial it is hoped that earlier, possibly correctable cases will be found. An autosomal dominant form of inheritance with variable penetrance is suggested in this family.
A retrospective survey of transfusion hepatitis associated with a brand of commercial Factor VIII was carried out in 24 Haemophilia Centres from January 1974 until December 1975. Of 371 patients who were transfused with this product, and were followed up, 78 cases of hepatitis affecting 66 patients were found (17.7%). Two types of hepatitis were observed: hepatitis B and non-B hepatitis, the latter with an incubation period of between 8 and 60 days. Twelve patients contracted two types of hepatitis, non-B followed by hepatitis B. Only one patient died after contracting hepatitis B. Four of the suspect batches of concentrate were found to be positive for HBsAg by radioimmunoassay. There was evidence that the presence of hepatitis B surface antibody in a patient's serum prior to exposure was associated with immunity to hepatitis B. Evidence was presented suggesting that the non-B hepatitis observed was not due to hepatitis A. The factors affecting the incidence of transfusion hepatitis in haemophiliacs were discussed.
Explore the source record for details and available documents.