A suppressor cell which interferes with antiallotype stimulated DNA synthesis of rabbit B cells.
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Biomedical subjects
Publications and source records attributed to B Cinader.
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Subpopulations of rabbit spleen cells which respond to T and B mitogens, respectively, can be distinguished by sedimentation velocity in the earth's gravitational field. T cell subpopulations which differed in their responsiveness to Con A and to PHA could be identified by differences in adherence properties and by their sensitivity to complement mediated cell kill with RTLA-antiserum.
Nocardia water soluble mitogen (NWSM) is known to stimulate mouse and rabbit lymphoid cells and to act selectively on murine B-derived lymphocytes. In this paper, evidence is presented that NWSM is also a mitogen for rabbit bursal equivalent cells and does not bring about blast transformation of thymus-derived rabbit cells. Pretreatment of rabbit spleen lymphocytes with antibody directed against rabbit thymus lymphocyte antigen (anti RTLA serum) and with complement did not affect the strong increase of thymidine incorporation which follows stimulation with NWSM. The mitogen-induced polyclonal activation of antibody-forming cells and resulted in the presence of 30% of cells with the ultrastructural characteristics of plasmocytes. These observations led to the conclusion that NWSM is a mitogen for a B-derived lymphocyte of the rabbit.
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