Biomedical subjects
Publications and source records attributed to B Christoforov.
A new case of avascular vertebral necrosis in a sixty-five-year-old woman is reported. Roentgenograms showed an intervertebral vacuum cleft leading to unequivocal diagnosis. The main features of vertebral necrosis are recalled.
The authors report two cases of acquired diverticulae of the small intestine with complications and study of pathological, clinical and therapeutic characteristics of this rare disease. Usually latent, these diverticulae were recognised generally during diverticulitis, intestinal obstruction, perforation or hemorrhage. The treatment was either removal of the diverticulum or segmental resection of the small intestine. Diverticulitis of the terminal ileum may lead to right ileo-colectomy.
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Haemoglobin Belfast was initially observed in an Irish patient. The second case, found in a French patient suffering from a metastatic carcinoma, is here described. Both observations are compared from clinical, haematological and biochemical points of view. Functional and spectrophotometrical studies confirmed the slight abnormalities already described.
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Wistar rat kidneys have been shown to possess a bilirubin glucuronyltransferase (BGT) activity capable of conjugating about 3/5 of the total pool of unconjugated bilirubin within 48 h of being grafted to Gunn rat hosts. Bilirubin conjugated by the kidney is taken up by the liver and excreted in the bile. Except when the bile duct is ligated, no conjugated bilirubin appears in the plasma or urine. Renal BGT activity is about 1/20th of the hepatic activity on a weight basis in Wistar rats. The Gunn rat's hyperbilirubinemia probably causes an induction of the renal enzyme since its activity doubles in 48 h.
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