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Biomedical subjects

B Chouvet

Publications and source records attributed to B Chouvet.

At least 55 records · Page 3Linked to original sources
PubMed1985

Treatment of progressive systemic sclerosis using factor XIII.

A double-blind, randomized crossover trial was carried out in 25 patients with progressive systemic sclerosis to compare the effectiveness and tolerability of treatment with Factor XIII with that of placebo. Patients received twice daily intravenous injections of either Factor XIII or placebo for 3 weeks and, after a wash-out period of 6 weeks, were crossed over to the alternative medication for a further 3 weeks. Assessments made by the physician and patients at the end of each treatment period indicated that Factor XIII was significantly better than placebo in improving the cutaneous manifestations of the disease and these opinions were supported by the significant improvement in the function index which was used to assess the degree of motor disability. Both local and general tolerability of Factor XIII treatment was good and there were no adverse reports.

Clinical Trials as Topic↗
PubMed1984

[Calcified Malherbe epithelioma of an unusual histological type].

A case of calcifying epithelioma (of Malherbe) is reported, which seems to be developing on an epidermal cyst: microscopic examination shows a sudden transformation of the wall of the epidermal cyst into a calcifying epithelioma. This histological feature is very rare: only 2 similar cases have been reported in the literature until now.

Adult↗
PubMed1983

[Skin lesions related to a new anti-inflammatory agent: fenbufen. Apropos of 3 clinical cases].

Three cases of generalized skin reactions occurred in patients undergoing oral therapy with Fenbufen (Cinopal), a new anti-inflammatory agent. The lesions spontaneously improved when the drug was discontinued. The role of Fenbufen in the pathogenesis of the lesions remains unclear. In the three cases, the detection of circulating immune complexes would suggest a sensibilization mechanism.

Adult↗
PubMed1983

[Buschke's scleredema and monoclonal dysglobulinemia: apropos of 3 cases].

A monoclonal gammopathy was observed in 3 adult patients with long-term and widespread scleredema (Buschke's disease). There was no evidence of multiple myeloma in any patient. The monoclonal immunoglobulin was in every case of the IgG-kappa type. Bence Jones proteinuria was noted in 1 case (kappa). Deposition of monoclonal IgG-kappa in the skin was not detected by immunofluorescence microscopy. These findings and previous reports of 5 cases suggest that diffuse scleredema may be frequently associated with paraproteinemia, but the role of monoclonal immunoglobulins in the pathogenesis of the disease remains to be clarified.

Adolescent↗
PubMed1982

[Acquired epidermolysis bullosa with Crohn's disease. Report of two cases and review of literature (author's transl)].

Two cases of acquired epidermolysis bullosa (A. E. B.) are reported in patients suffering from Crohn's disease. Microscopic examination showed in both cases a subepidermal blister with pieces of basal membrane among the roof of the blister. In the second case, linear deposits of IgG and C3 were observed by direct immunofluorescence at the dermoepidermal junction in the juxtalesional skin. No circulating antiepidermis antibody were found by indirect immunofluorescence in any of the two cases. Presence of immune complexes was evidenced. A review is presented of similar cases in the literature and of the frequence of the pathological associations. No peculiar feature of A. E. B. when associated to Crohn's disease was found: the course of the two diseases is independent; however, we did observe an improvement of skin lesions by the time of the intestinal remission in the first case. The pathogenesis of this association is still unclear. Autoimmune mechanism might possible play a role, but is still unknown.

Adult↗
PubMed1980

[Immunosuppressive therapy and Kaposi's sarcoma: two case reports (author's transl)].

The authors report 2 cases of Kaposi's sarcoma in whose immunosuppressive therapy is implicated. In a 47-year-old Italian man, cutaneous lesions were rapidly aggravated after a renal transplant and treatment with corticosteroids and azathioprine; new lesions appeared close to an arteriovenous fistula of the forearm. In a 83-year-old Algerian man, Kaposi's sarcoma appeared during steroid therapy for bullous pemphigoid. The role of acquired immunosuppression, local predisposition and genetical factors are reviewed and discussed for the pathogenesis of Kaposi's sarcoma.

Aged↗