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Biomedical subjects

B Campbell

Publications and source records attributed to B Campbell.

At least 163 records · Page 9Linked to original sources
PubMed1978

Social and attentional aspects of echolalia in highly echolalic mentally retarded persons.

Echolalia was examined in a sample of highly echolalic mentally retarded individuals. When presented with a standard set of questions, under conditions differing in appropriateness for exchange of discourse (e.g., questions presented with examiner and patient face-to-face vs. questions presented with the examiner's face averted vs. questions addressed towards another person sitting silently beside the patient), subjects' frequency of echolalia varied. Besides showing considerable sensitivity to aspects of discourse exchange, subjects exhibited some limited capacity for processing linguistic information.

Adolescent↗
PubMed1976

The effect of diphenylhydantoin on the microbial assay of serum folate.

1. Two modifications fo the usual method of assay for folic acid in solutions are reported which appear to improve this procedure. These are a reduction of incubation time and dilution with 95% ethanol. 2. Experimental results are reported which indicate that Dilantin (5,5-diphenylhydantoin) does not interfere with the microbiological assay for folic acid.

Biological Assay↗
PubMed1976

Synthetic glycolipid adjuvants.

In the course of the organic synthesis of model compounds similar in some features to the lipid moiety of endotoxic lipopolysaccharide (LPS), Nacylated-D-glucosamine derivatives were prepared. One of these, N-palmitoyl-D-glucosamine, has been previously found to be mitogenic for athymic nude mouse B cells. This and other N-acylated homologs were tested for adjuvant activity in the immune response to human gamma-globulin (HGG) and sheep red blood cells (SRBC) in mice. Comparable or superior enhancement of the immune response was obtained for these glycolipids when compared to LPS in assays measuring anti-SRBC or HGG hemagglutinin titers. In the determination of hemolytic plaque formation, considerable adjuvant effect was shown by the lauroyl derivative, and less but still significant enhancement was achieved by the N-palmitoyl-D-glucosamine. In the rosette formation assay, in addition to the above two glycolipids, N-oleyl-D-glucosamine showed good adjuvant effect. In the latter two assays, the LPS was a superior adjuvant as compared to the synthetic glycolipids. The radiation protective effect of some of the better synthetic adjuvants was also investigated in mice. It was found that although LPS was more effective in this assay, the N-myristoyl-D-glucosamine and N-decanoyl-D-glucosamine compounds gave a definite protection, since up to 40% of the lethally irradiated (700 R) mice survived.

Adjuvants, Immunologic↗