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Biomedical subjects

B C Wolf

Publications and source records attributed to B C Wolf.

43 records · Page 3Linked to original sources
PubMed1986

Bone marrow morphology and immunology in systemic amyloidosis.

Bone marrow specimens from 45 patients presenting with signs and symptoms of systemic amyloidosis were studied to assess the degree and pattern of plasmacytosis and its clonality, using immunohistologic technics. Twenty-four of 35 patients with primary amyloidosis had monoclonal plasma cells, while 11 had polyclonal plasma cells. Five patients with secondary amyloidosis and five with familial amyloidosis had a mild polyclonal plasmacytosis. The authors' data suggest that there may be two subgroups of patients with primary amyloidosis: those with monoclonal plasmacytosis representing part of the spectrum of plasma cell dyscrasias, and those in which a monoclonal plasmacytosis cannot be documented. Immunohistologic staining of bone marrows in patients with amyloidosis may be of future value in characterizing subtypes of amyloidosis and evaluating their relationship to multiple myeloma.

Amyloidosis↗
PubMed1986

Silicone-induced endocarditis. A complication of transvenous cardiac pacing catheterization.

We report a case of silicone-induced endocarditis as a newly recognized complication of transvenous cardiac pacing catheterization. Silicone was found embedded in thrombotic vegetations on the tricuspid valve of a patient who had a long-standing pacing catheter in the right side of his heart. Scanning electron microscopy and energy-dispersive x-ray analysis confirmed the presence of silicone in the vegetations and in the catheter tip.

Aged↗
PubMed1985

Malignant lymphoma presenting with prominent splenomegaly. A clinicopathologic study with special reference to intermediate cell lymphoma.

Although non-Hodgkin's lymphoma presenting with prominent splenomegaly is a well-recognized clinical syndrome, previous reports of such cases create confusion today because of the use of outdated pathologic classifications, awkward or inappropriate terms, and imprecise diagnostic criteria. The authors have studied 31 such cases and have classified them according to the modified Rappaport and Lukes-Collins classifications as well as the recently introduced International Working Formulation. Most of our cases (30/31) of malignant lymphoma presenting with prominent splenomegaly were of the small cell type, with morphologic and/or immunologic evidence of B-cell origin. The single largest subtype in our series (19/30) was intermediate lymphocytic lymphoma (IL), a recently described entity in which this mode of presentation has not been previously emphasized. Although such cases have been termed "primary splenic lymphoma," almost all are disseminated diseases that pursue a progressive course and require multiagent chemotherapy and/or radiotherapy.

Adult↗
PubMed1985

Adrenal pheochromocytoma: a clinicopathologic review of 60 cases.

The clinical and pathologic features of 60 adrenal pheochromocytomas were reviewed in an attempt to evaluate the utility of histopathologic evaluation in predicting the prognosis for these tumors. Fifty-five tumors were benign, and five were malignant, characterized either by histologically proved metastases or by extensive local invasion. The prevalence of all parameters studied was compared between the benign and malignant groups. Three differences were observed between the benign and malignant tumors. The malignant tumors were usually larger, had extensive areas of necrosis, and were composed of small cells. In agreement with the results of previous investigations, the morphologic criteria generally used to predict the behavior of tumors, i.e., nuclear atypia, capsular and vascular invasion, and mitotic activity, were of little value in predicting the behavior of adrenal pheochromocytomas. Fifteen tumors, all of which had membrane-bound, cytoplasmic granules, were examined electron microscopically. A minority of these tumors fit the classic descriptions of "norepinephrine" and "epinephrine" granules reported in the literature, while the majority of the granules had features of both types, precluding definitive classification. As a result of these observations, the currently accepted criteria of norepinephrine and epinephrine granules were questioned. A review of the literature cast further doubt on the existence of a correlation between granule content and morphology. Both of the patients with locally invasive malignant tumors were alive and well eight and 28 years following diagnosis and radical surgery. In contrast, the patients with histologically proved distant metastases died within one year of diagnosis. These observations suggest that locally invasive tumors may not have the same dismal prognosis as adrenal pheochromocytomas that have metastasized.

Adipose Tissue, Brown↗
PubMed1985

Myelofibrosis with myeloid metaplasia: pathophysiologic implications of the correlation between bone marrow changes and progression of splenomegaly.

We undertook a study of 35 cases of myelofibrosis with myeloid metaplasia to assess the histopathologic findings in the bone marrow of patients with this disorder, to ascertain if changes in morphology occurred with time, and to attempt to correlate marrow findings with splenic size. We reviewed 71 bone marrow biopsies and studied 13 splenectomy specimens. Sequential bone marrow biopsies were obtained in 21 cases over intervals ranging from two to ten years (mean, 4 1/2 years). We noted a patchy nature and variable degree of stromal proliferation in most marrow biopsies, and were unable to demonstrate a correlation between the extent of medullary fibrosis and duration of disease, splenic weight, or degree of splenic myeloid metaplasia. We were unable to document a progression of medullary fibrosis as a cause for increasing splenomegaly. However, the alteration in the marrow stroma in this disorder is responsible for the presence of distended marrow sinusoids with intravascular hematopoiesis, a phenomenon we observed in all cases. We believe that this morphological feature, not emphasized by previous investigators, is of significance in understanding the pathophysiology of myeloid metaplasia.

Adult↗
PubMed1983

Evidence to suggest that the human fetal spleen is not a hematopoietic organ.

The human fetal spleen commonly is regarded as an organ of hematopoiesis. Because of the authors' interest in myelofibrosis with myeloid metaplasia (MMM) and because the myeloid metaplasia commonly is regarded as a reactivation of embryonic sites of blood formation, spleens from 48 fetuses and stillborn infants were studied, in an attempt to evaluate splenic hematopoiesis (myelopoiesis). The authors employed immunohistologic and cytochemical technics to identify granulocytic, erythroid, and megakaryocytic cells, in contrast to previous studies that have relied solely on conventional morphology. The authors found surprisingly little evidence of hematopoiesis. Virtually no hematopoietic cells of the dividing cell pool were identified, in spite of the fact that the technic used is capable of detecting such immature forms. The results suggests that the spleen is not a significant organ of hematopoiesis in the human fetus but that immature hematopoietic cells found there merely reflect trapping of circulating precursors in the fetal blood. These findings have significant implications for the pathophysiology of MMM.

Erythrocytes↗