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Biomedical subjects

B C Sheu

Publications and source records attributed to B C Sheu.

23 records · Page 2Linked to original sources
PubMed1995

Limb defects after chorionic villus sampling.

OBJECTIVE: To clarify the association between limb defects and chorionic villus sampling (CVS). METHODS: Questionnaires were sent to 165 major obstetric units in Taiwan to survey the incidence of limb defects with and without CVS exposure during 1991. Limb defects with CVS exposure from September 1990 to June 1992 were also surveyed. The spectrum of limb defects in CVS-exposed and general populations were compared by the Poisson test. RESULTS: The incidence of limb defects in the surveyed general population in 1991 was 0.032% and that with CVS exposure was 0.294%, a statistically significant difference (P < .001). The incidence of severe limb defects in the general population was 0.0026% and that with CVS exposure was 0.22%, also statistically significant (P < .001). Twenty-nine cases of limb defects after CVS were reported from September 1990 until June 1992: 19 cases with transverse limb reduction, two with mid-palm reduction, seven with adactyly or hypodactyly, and one with syndactyly. Four cases also had oromandibular-limb hypogenesis syndrome. CONCLUSIONS: The incidence of limb defects, especially the severe types, was increased after CVS. The spectrum of limb defects with CVS exposure was more severe than the limb defects seen in the general population and showed a specific pattern ranging from hypodactyly, adactyly, and transverse limb reduction, to oromandibular-limb hypogenesis. A correlation between the severity of limb defects and the timing of CVS was suggested.

Abnormalities, Multiple↗
PubMed1994

Ultrasound diagnosis of rudimentary uterine horn pregnancy in fourteen weeks of gestation: a case report.

Pregnancy in a rudimentary uterine horn is rare. Rupture tends to occur in the second trimester, and results in maternal morbility and mortality. Although the diagnosis prior to rupture is difficult, early detection is essential in avoiding a fatal outcome. An asymptomatic case of pregnancy in the rudimentary horn of a bicornuate uterus prior to rupture is presented. This report is to emphasize the important value of sonography for early detection of the prerupture of the rudimentary pregnancy.

Adult↗
PubMedDate not supplied

Down-regulation of CD25 expression on the surface of activated tumor-infiltrating lymphocytes in human cervical carcinoma.

To investigate the activation status of tumor-infiltrating lymphocytes (TILs) within the tumor milieu of human cervical carcinoma, we quantitatively measured and compared the activation markers on lymphocyte subpopulations which infiltrating normal and neoplastic cervix. A total of 20 patients with stage IA to IIA cervical cancer (cancer group) and 10 women with normal cervix (control group) were enrolled in this study. Mononuclear cells were isolated from tissue specimens by mechanical dispersal technique and three-color flow cytometry was utilized for the quantification of activation markers on lymphocyte subsets. Compared with control group, lymphocytes isolated from cancer tissue consisted of higher proportions of B cells (7.23% +/- 4.49% vs. 3.67% +/- 3.19%, P = 0.016) and T cells (72.33% +/- 8.70% vs. 53.15% +/- 17.36%, P = 0.004), but an inverted CD4:CD8 ratio (0.74 +/- 0.27 vs. 1.14 +/- 0.28, P = 0.002) and decreased NK cells (7.53% +/- 4.33% vs. 16.00% +/- 11.82%, P = 0.035). Low expression of CD25, but not CD69 and HLA-DR was observed on both CD4+CD3+ and CD8+CD3+ T cells derived from cervical cancer (P < 0.0001). Further dual activation marker analysis demonstrated that the expression of CD25 was dissociated from CD69 and HLA-DR on the same TILs in cancer tissue (P < 0.001). TILs in the tumor microenvironment can be functionally inhibited and lose the ability of clonal proliferation due to depressed expression of CD25.

Antigens, Differentiation, T-Lymphocyte↗
PubMedDate not supplied

Fibronectin levels in normal pregnancy and preeclampsia.

Vascular endothelial damage is reported to be the prime cause of preeclampsia, and elevated levels of fibronectin have been found before clinical signs of preeclampsia were manifested. The total plasma fibronectin concentrations in 212 blood samples from 173 normotensive healthy pregnant women at various gestational ages were measured. Fibronectin levels were also determined for 20 blood samples from 20 preeclamptic patients obtained at the time of clinical manifestation of preeclampsia. Blood samples from 46 non pregnant women of reproductive age were used as controls. The results showed that the total plasma fibronectin concentration during reproductive age was independent of age and the average level during pregnancy decreased with gestational age. Preeclamptic patients had a significantly elevated level of total fibronectin compared with healthy pregnant women. The total fibronectin concentration is a promising biochemical marker for preeclampsia, but a more specific endothelial method of measurement is needed before it is put to clinical use.

Adult↗