Usefulness of the staged excision for lentigo maligna and lentigo maligna melanoma.
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Biomedical subjects
Publications and source records attributed to B C Schultz.
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A new technic is described for more accurately checking the surgical margins of skin tumors removed by standard surgical excision. Vertical sections of surgical specimens represent check points of the margin only 7 microns thick. This means most of the surgical margin is not checked microscopically, allowing small tumor islands at the margin to remain undetected. The technic is applicable wherever surgical excision is used to excise skin tumors. It is especially suitable for basal cell carcinoma. A variable-width knife holding two scalpel blades parallel to each other is set at 2 to 3 mm separation. When the excision is done as usual, the blades will cut a 2- to 3-mm strip of tissue representing the entire lateral borders of the excision. This specimen is easily mounted as a flat section for frozen or paraffin processing. These sections will be cut to show the entire lateral excision margin to be checked for tumor. A new punch with concentric cutting edges separated by 2 mm has been made to obtain a similar flat section. The circular defect is converted to a standard ellipse and closed primarily. This technic has the advantage of using primary closure for excellent cosmetic results. It requires little additional skill on the part of the surgeon and is easily handled by the pathology laboratory. It has been used in thirteen cases with no recurrence of tumors to date.
This study evaluated the treatment of uremic pruritus with ultraviolet B light in patients with chronic renal failure and severe pruritus not attributed to other skin or internal disease. Eight of ten patients responded with complete relief of itching. Photoinactivation of a yet unidentified substance could explain the success of this treatment.
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A 17-year-old boy had a large, scarred area of alopecia from a thermal burn. Forty square centimeters of scarred scalp skin were excised in six sessions. The cosmetic result was excellent. Neither hypertrophic nor keloidal scarring supervened. The technique of scalp reduction and its procedure as an adjunct to hair transplantation is discussed.
Beads of the material that is commercially purveyed as Debrisan were used as a postoperative dressing after dermabrasion in 24 patients. Fifteen of seventeen patients so dressed on only half of the dermabraded area expressed preference for it. The beads absorbed drainage and were protective of the dermabraded half. Five of the seventeen patients developed milia one month after dermabrasion and three of the five had them only on the side treated with the beads of Debrisan.
Two mentally retarded siblings, one with severe segmental scleroderma and the other with atrophoderma of Pasini and Pierini, were found at the ages of 6 and 10 years to have phenylketonuria (PKU). The belief that a common pathomechanism exists between morphea and atrophoderma of Pasini and Pierini is supported by the case of the two siblings. Disorders in tryptophan metabolism can occur in both PKU and scleroderma. For a low phenylalanine diet to be effective in PKU, it has to be instituted at an early age. Phenylketonuria should be considered in infants and children with sclerodermatous skin lesions.
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