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Biomedical subjects

B C Patel

Publications and source records attributed to B C Patel.

79 records · Page 5Linked to original sources
PubMed1975

Lectin-receptor interactions in liposomes.

The major sialoglycoprotein of mammalian erythrocytes has been incorporated into phosphatidylcholine membranes to generate a model system, glycoprotein-liposomes. Electron microscopic examination revealed these structures to be vesicles, approximately 300 A in diameter. An aqueous compartment inside the glycoprotein-liposomes has been identified by trapped volume studies with [14C]sucrose. These glycoprotein-liposomes were found to interact with the lectins, wheat germ agglutinin, and phytohemagglutinin, to form aggregates of mainly unfused vesicles. The aggregation process has been studied by electron microscopy, 90 degrees light scattering, and differential ultracentrifugation analysis. Hapten inhibitors of the lectins were found to inhibit the lectin-induced aggregation of the glycoprotein-liposomes. Binding of 125I-labeled wheat germ agglutinin to glycoprotein-liposomes was studied by differential ultracentrifugation. Hapten inhibitors of wheat germ agglutinin were also found to inhbit the binding of 125I-labled wheat germ agglutinin to the glycoprotein-liposomes. The characteristics of the lectin interactions with glycoprotein-liposomes appeared to be phenomenologically similar to lectin-cell interactions.

Acetylglucosamine↗
PubMed1975

Failure of increased brain gamma-aminobutyric acid levels to influence amphetamine-induced stereotyped behavior.

Increased brain gamma-aminobutyric acid (GABA) levels secondary to the administration of sodium valproate failed to inhibit amphetamine-induced stereotyped behavior. This observation raises some doubt as to whether GABA plays a role in the physiology of the striatum and suggests that GABA does not play a role in the pathophysiology of chorea. If this is true, pharmacologic attempts to increase brain GABA may not improve human choreatic disorders.

Aminobutyrates↗
PubMedDate not supplied

Nodular cutaneous amyloid tumors of the eyelids in the absence of systemic amyloidosis.

A patient was referred with recurrent bilateral, slow-growing, painless, nodular tumors of the upper eyelid margins. The tumors were excised and the base of each lesion was ablated with the CO2 laser. Histological examination of the excised tissue revealed amyloid. Despite the fact that cutaneous, amyloid lesions of the eyelid have been previously described as essentially pathognomonic for systemic amyloid disease, no evidence of systemic amyloidosis was found in this patient. We believe that this represents only the second reported case of bilateral cutaneous amyloid of the eyelids without systemic involvement. We agree with previous authors that this lesion be added to the list of painless slow-growing bilateral eyelid tumors.

Amyloidosis↗