Automatic control of blood pressures with multiple drug inputs.
Control of arterial blood pressure has been successfully achieved by infusing a single vasoactive drug. However, in clinical practice, blood pressures are frequently controlled using multiple drug infusions. This paper presents a computer based adaptive control algorithm for simultaneous infusions of both an inotropic agent and a vasoactive agent to maintain the blood pressures at desired levels. We present the dynamics of the system with a bilinear two-input, two-output model. A least-squares parameter estimation algorithm has been employed using an output error method. Results of computer simulations of an electrical analog model of the heart and circulatory system are presented.
Biomedical Engineering↗