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Biomedical subjects

B C Goodwin

Publications and source records attributed to B C Goodwin.

34 records · Page 2Linked to original sources

Waves and periodic events during primitive streak formation in the chick.

Morphogenetic movements occurring during formation of the primitive streak in the chick embryo are of a periodic nature, with a mean frequency of one pulse every 2.6 min. The period of the oscillatory movement is shown to be temperature-dependent. The onset of these pulses of movement can be seen as a slow wave starting at the posterior end of the embryo and making its way towards the anterior end. An interpretation of this behaviour is discussed.

Animals↗

An inhibitor of DNA synthesis in erythrocyte-conditioned medium and its separation from haemoglobin.

Erythrocyte-conditioned medium and erythrocyte lysate have been prepared from rat red blood cells. Molecular fractions of the conditioned medium and the lysate are used to test for the presence of erythrocyte chalone in short-term tissue cultures of mouse foetal liver cells. An inhibitor of erythroblast DNA synthesis has been found in the erythrocyte conditioned medium. The inhibitor is not haemoglobin, and it is not found in erythrocyte lysate soluble components.

Animals↗

Growth response of mouse lymphoma cells to low concentrations of mercuric chloride.

Three growth rate experiments involving several sampling points were performed to investigate the previous finding that very low concentrations of HgCl2 inhibit the growth of murine lymphoblasts in vitro. However, results presented here do not confirm this, there being no significant differences between the three independent growth rate experiments.

Animals↗