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Biomedical subjects

B C Anderson

Publications and source records attributed to B C Anderson.

67 records · Page 4Linked to original sources

Olfactory neuroblastoma in a heifer.

A nasal neuroblastoma (esthesioneuroblastoma) extending into the brain in a heifer produced mouth breathing and proptosis. The mass filled much of the left nasal cavity, palatine sinus and maxillary sinus, with turbinate atrophy and deviation of the septum. Caudally the neoplasm extended into the nasopharynx and olfactory bulb. It was a cellular neoplasm composed of small, undifferentiated piriform cells showing infrequent pseudorosettes and immature axonal processes. Mitosis was common is some areas.

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Mastitis and udder abnormalities as related to neonatal lamb mortality in shed-lambed range ewes.

Bacterial isolations were attempted from milk samples taken from 242 range ewes in a southwestern Idaho shed lambing enterprise. Eighty-five percent of the ewe milk samples had no pathogenic bacterial growth at lambing and 3 weeks later. The few organisms that were isolated did not appear to affect udder condition of the ewe or contribute to lamb mortality. Shed conditions did not affect the frequency of isolation of potentially pathogenic bacteria. The prevalence of udder abnormalities, however, did appear to have a positive association with ewes that lost theim lambs. The most frequent abnormality was a diffuse homogeneous induration of the udder. This hardening was apparently unrelated to bacterial isolation or the age of the ewes. Mastitis, either subclinical or clinical, did not appear to be a serious problem in this particular flock. Mastitis was not related to lamb mortality.

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Portal hypertension secondary to a right atrial tumor in a dog.

A German Shepherd Dog was examined because of ascites and hepatomegaly. The finding of proteinaceous ascitic fluid and hepatic histologic features of centrizonal sinusoidal congestion suggested hepatic venous outflow obstruction. Diagnostic tests eliminated heart failure from the differential diagnosis and thus indicated an obstruction between the right atrium and hepatic sinusoids. Vascular manometry and angiography established the site of the lesion in the right atrium and confirmed portal vein hypertension. Surgical exploration revealed an unresectable right atrial tumor occluding the caudal vena cava.

Animals↗

Feasibility of outpatient self-administration of parenteral antibiotics.

It is customary to treat patients with infective endocarditis or osteomyelitis for a prolonged period in hospital with parenteral antibiotics. It was felt that it might be feasible to allow parenteral administration of antibiotics by the patients themselves at home. Results in 13 patients who administered antibiotics parenterally themselves (experimental group) were compared with those in 7 patients (control group) treated entirely within the hospital. Antibiotic-related complications were similar in both groups. There was no instance of infection of the intravenous cannula in either group. The average daily cost of antibiotic therapy decreased from $243.22 for inpatients to $69.35 for outpatients. The average cost of illness was $6,357.22 in the experimental group and $10,022.23 in the control group. If patients are carefully selected and well educated, the outpatient self-administration of antibiotics parenterally is both economical and safe.

Adult↗

Monocytic leukemia in three cats.

Of 3 cats with monocytic leukemia, 1 responded favorably to treatment with cytosine arabinoside. With supportive therapy, it lived 78 days from the time of diagnosis, at which time it developed dyspnea and signs of toxicosis and died. The other 2 cats did not respond to treatment and died 4 and 16 days from time of diagnosis. Prior to death, they were bleeding from injection sites, and their blood had greater than 200,000 WBC/mm3. Necropsy of those 2 cats revealed extensive perivascular hemorrhagic infarcts within the cerebellum, medulla, and cerebrum.

Animals↗

Partial deficiency of antidiuretic hormone in a cat.

Marked polydipsia and polyuria developed subsequent to trauma in a 1 1/2-year-old male Abyssinian cat. Diabetes insipidus was suspected, inasmuch as intramuscualr vasopressin administration resulted in amelioration of polydipsia and polyuria. However, hypertonic (3%) saline solution given intravneously resulted in anuria, an indication of antidiuretic hormone activity. Polyuria and polydipsia were abolished by oral chlorpropamide therapy, which was indirect evidence for partial deficiency of antidiuretic hormone.

Animals↗

Polymyositis and polyarthritis associated with systemic lupus erythematosus in a dog.

Systemic lupus erythematosus with polymyositis and polyarthritis was diagnosed in a 7-year-old female Standard Poodle. Pertinent clinical signs included extreme muscular weakness, muscle wasting, atrial fibrillation, and dysphagia due to megaesophagus. Aspiration pneumonia secondary to the megaesophagus contributed to the death of the dog. Serum muscle enzyme activities were increased. Electromyographic findings included fibrillation potentials, positive sharp waves, increased insertional activity, and bizarre high-frequency repetitive potentials. Histopathologic findings in skeletal muscle included myofiber necrosis and phagocytosis; regeneration of myofibers; perivascular and interstitial infiltrations of macrophages, lymphocytes, and plasma cells; and type I and II myofiber degeneration and vacuolation.

Animals↗

Hemochromatosis in Salers cattle.

Two 2-year-old Salers cattle from different herds raised on pasture were evaluated for retarded growth and diarrhea. Increase of liver enzyme activities and prolonged sulfobromophothalein (BSP) half life (T1/2) indicated liver disease with impaired liver function. Histopathologic examination of liver biopsies revealed a micronodular cirrhosis with marked deposition of hemosiderin in hepatocytes, Kupffer cells, and arterioles. Transferrin saturation (TS) and liver iron content were markedly increased, consistent with a diagnosis of hemochromatosis. Both animals were euthanatized due to deterioration in their condition. Necropsy findings included hepatomegaly and hemosiderin accumulation in the liver, lymph nodes, pancreas, spleen, thyroid, kidney, brain and other glandular tissue. Continued surveillance of the second herd (serum iron, total iron binding capacity [TIBC], unsaturated iron binding capacity [UIBC], and TS), identified a heifer as a hemochromatosis suspect in a subsequent generation. Liver biopsies from that animal revealed the same histopathologic changes as the previous 2 animals, and similar increases in liver iron content (8,700 ppm, normal range 45 to 300 ppm). The 3 affected cattle were all products of line breeding programs and shared a common ancestor. The absence of dietary iron loading in conjunction with the histopathologic and metabolic findings were consistent with a diagnosis of primary hemochromatosis. The reported disease is similar to idiopathic hemochromatosis in human beings in which there is a hereditary defect in iron metabolism.

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Evaluation of ergonomic dental stools through clinical simulation.

Work-related musculoskeletal pain occurs commonly within the dental community. Three stool designs were utilized in this study: a standard dental stool, a stool with dual arm supports, and a stool with dual arm supports and chest support. Electromyographic data from four muscle groups were collected on 13 clinicians during a simulated crown preparation procedure. Clinical simulation suggests that a potential musculoskeletal benefit to the clinician exists through utilization of dental stool designs which incorporate static arm supports.

Adult↗

Prevalence of Cryptosporidium muris-like oocysts among cattle populations of the United States: preliminary report.

As part of a national survey for bovine, Cryptosporidium muris oocysts, fecal smears in the form of up to 144, 3- to 5-mm dots per glass slide were prepared from pen samples at dairies and feedlots in the eastern and western United States. Acid-fast staining was followed by light microscopic evaluation at x100. Samples from 150 dairies numbered 48,810 and those from 30 feedlots, 47,064. Positive samples were found at 102 (68%) dairies and 24 (80%) feedlots. Overall, prevalence of positive samples by state was up to 4.7% (Virginia dairies), but within certain pens of cattle, 31% (Connecticut dairy) and 11.8% (California feedlot) of the samples were positive.

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Experimental infection in mice of Cryptosporidium muris isolated from a camel.

Cryptosporidium muris-like oocysts in 5 g of camel feces were concentrated by the Sheather sugar flotation method, saline-washed, pelleted and reconstituted to an approximate concentration of 2.5 million per ml. One- to 2-microliters inocula were given per os to 25 2- to 20-day-old mice, with 15 contact control litter-mates. The 15- and 20- day inoculates had acid-fast-positive fecal smears by day-12 after inoculation. Necropsies of mice inoculated at 2 and 5 days of age showed colonization only of gastric glands by day-12, and day-27, respectively. Control mice were negative. Identical methods using similar oocysts from cattle produced no evidence of transmission.

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